Effect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats : impact on inflammatory response, lipid profile, and gut microbiota
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| Hlavní autor: | |
|---|---|
| Datum vydání: | 2022 |
| Další autoři: | , , |
| Médium: | Article |
| Jazyk: | eng |
| Zdroj: | Repositório Institucional da UnB |
| Download full: | http://repositorio2.unb.br/jspui/handle/10482/47160 https://doi.org/10.1371/journal.pone.0262270 https://orcid.org/0000-0002-9826-6004 |
Shrnutí: | Coffee beans contain high polyphenol content, which have the potential to modulate the intestinal microbiota, and possibly attenuate weight gain and the associated dyslipidemia. This study investigated the effect of freeze-dried coffee solution (FCS) consumption on physiological parameters, lipid profile, and microbiota of Wistar rats fed a high-fat diet (HF) or control diet (CT). FCS combined with a high-fat diet increased the fecal and cecal Bifidobacterium spp. population and decreased the cecal Escherichia coli population and intestinal Il1b mRNA level. Regardless of the diet type, FCS increased the serum high-density lipoprotein cholesterol (HDL-C); however, it did not affect body weight, food intake, low-density lipoprotein, triglycerides, fecal bile acids, and intestinal Il6 mRNA levels. The high-fat diet increased weight gain, hepatic cholesterol and triglycerides, fecal bile acids, and the fecal and cecal Lactobacillus spp. population, and reduced food intake, the fecal E. coli population, and intestinal Il6 mRNA level. The results suggest that FCS consumption exhibits positive health effects in rats fed a high-fat diet by increasing Bifidobacterium spp. population and HDL-C reverse cholesterol transport, and by reducing Il1b mRNA level. However, FCS administration at a dose of 0.39 g/100 g diet over an eight-week period was not effective in controlling food intake, and consequently, preventing weight gain in rats of high-fat diet-induced obesity model. |
| _version_ | 1871442285313392640 |
|---|---|
| author | Cavalcanti, Marilia Hermes |
| author2 | Roseira, João Paulo Santos Leandro, Eliana dos Santos Arruda, Sandra Fernandes |
| author2_role | author author author |
| author_browse | Arruda, Sandra Fernandes Cavalcanti, Marilia Hermes Leandro, Eliana dos Santos Roseira, João Paulo Santos |
| author_facet | Cavalcanti, Marilia Hermes Roseira, João Paulo Santos Leandro, Eliana dos Santos Arruda, Sandra Fernandes |
| author_role | author |
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| bitstream.url.fl_str_mv | http://repositorio2.unb.br/jspui/bitstream/10482/47160/1/ARTIGO_EffectFreeze-driedCoffee.pdf http://repositorio2.unb.br/jspui/bitstream/10482/47160/2/license.txt |
| collection | Repositório Institucional da UnB |
| dc.contributor.affiliation.pt_BR.fl_str_mv | Universidade de Brasília, Faculty of Health Sciences, Postgraduate Program in Human Nutrition Universidade Federal de Viçosa, Department of Animal Science Universidade de Brasília, Faculty of Health Sciences, Postgraduate Program in Human Nutrition Universidade de Brasília, Faculty of Health Sciences, Postgraduate Program in Human Nutrition |
| dc.contributor.author.fl_str_mv | Cavalcanti, Marilia Hermes Roseira, João Paulo Santos Leandro, Eliana dos Santos Arruda, Sandra Fernandes |
| dc.date.accessioned.fl_str_mv | 2024-01-05T13:05:02Z |
| dc.date.available.fl_str_mv | 2024-01-05T13:05:02Z |
| dc.date.issued.fl_str_mv | 2022-01-26 |
| dc.identifier.citation.fl_str_mv | CAVALCANTI, Marilia Hermes et al. Effect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats: impact on inflammatory response, lipid profile, and gut microbiota. PLoS ONE, [S. l.], v. 17, n. 1, e0262270, 2022. DOI: https://doi.org/10.1371/journal.pone.0262270. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0262270. Acesso em: 05 jan. 2024. |
| dc.identifier.doi.pt_BR.fl_str_mv | https://doi.org/10.1371/journal.pone.0262270 |
| dc.identifier.orcid.pt_BR.fl_str_mv | https://orcid.org/0000-0002-9826-6004 |
| dc.identifier.uri.fl_str_mv | http://repositorio2.unb.br/jspui/handle/10482/47160 |
| dc.language.iso.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Plos |
| dc.rights.driver.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
| dc.subject.keyword.pt_BR.fl_str_mv | Dietas Café Bile Bifidobactérias Escherichia coli Obesidade Lactobacilos |
| dc.title.pt_BR.fl_str_mv | Effect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats : impact on inflammatory response, lipid profile, and gut microbiota |
| dc.type.driver.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Coffee beans contain high polyphenol content, which have the potential to modulate the intestinal microbiota, and possibly attenuate weight gain and the associated dyslipidemia. This study investigated the effect of freeze-dried coffee solution (FCS) consumption on physiological parameters, lipid profile, and microbiota of Wistar rats fed a high-fat diet (HF) or control diet (CT). FCS combined with a high-fat diet increased the fecal and cecal Bifidobacterium spp. population and decreased the cecal Escherichia coli population and intestinal Il1b mRNA level. Regardless of the diet type, FCS increased the serum high-density lipoprotein cholesterol (HDL-C); however, it did not affect body weight, food intake, low-density lipoprotein, triglycerides, fecal bile acids, and intestinal Il6 mRNA levels. The high-fat diet increased weight gain, hepatic cholesterol and triglycerides, fecal bile acids, and the fecal and cecal Lactobacillus spp. population, and reduced food intake, the fecal E. coli population, and intestinal Il6 mRNA level. The results suggest that FCS consumption exhibits positive health effects in rats fed a high-fat diet by increasing Bifidobacterium spp. population and HDL-C reverse cholesterol transport, and by reducing Il1b mRNA level. However, FCS administration at a dose of 0.39 g/100 g diet over an eight-week period was not effective in controlling food intake, and consequently, preventing weight gain in rats of high-fat diet-induced obesity model. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UNB_3d60e2745f0fcd514ce9879e603e6bfb |
| identifier_str_mv | CAVALCANTI, Marilia Hermes et al. Effect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats: impact on inflammatory response, lipid profile, and gut microbiota. PLoS ONE, [S. l.], v. 17, n. 1, e0262270, 2022. DOI: https://doi.org/10.1371/journal.pone.0262270. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0262270. Acesso em: 05 jan. 2024. |
| instacron_str | UNB |
| institution | UNB |
| instname_str | Universidade de Brasília (UnB) |
| language | eng |
| network_acronym_str | UNB |
| network_name_str | Repositório Institucional da UnB |
| oai_identifier_str | oai:repositorio.unb.br:10482/47160 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher.none.fl_str_mv | Plos |
| reponame_str | Repositório Institucional da UnB |
| repository.mail.fl_str_mv | repositorio@unb.br |
| repository.name.fl_str_mv | Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| repository_id_str | |
| spelling | Cavalcanti, Marilia HermesRoseira, João Paulo SantosLeandro, Eliana dos SantosArruda, Sandra FernandesUniversidade de Brasília, Faculty of Health Sciences, Postgraduate Program in Human NutritionUniversidade Federal de Viçosa, Department of Animal ScienceUniversidade de Brasília, Faculty of Health Sciences, Postgraduate Program in Human NutritionUniversidade de Brasília, Faculty of Health Sciences, Postgraduate Program in Human Nutrition2024-01-05T13:05:02Z2024-01-05T13:05:02Z2022-01-26CAVALCANTI, Marilia Hermes et al. Effect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats: impact on inflammatory response, lipid profile, and gut microbiota. PLoS ONE, [S. l.], v. 17, n. 1, e0262270, 2022. DOI: https://doi.org/10.1371/journal.pone.0262270. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0262270. Acesso em: 05 jan. 2024.http://repositorio2.unb.br/jspui/handle/10482/47160https://doi.org/10.1371/journal.pone.0262270https://orcid.org/0000-0002-9826-6004engPlos© 2022 Cavalcanti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.info:eu-repo/semantics/openAccessEffect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats : impact on inflammatory response, lipid profile, and gut microbiotainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDietasCaféBileBifidobactériasEscherichia coliObesidadeLactobacilosCoffee beans contain high polyphenol content, which have the potential to modulate the intestinal microbiota, and possibly attenuate weight gain and the associated dyslipidemia. This study investigated the effect of freeze-dried coffee solution (FCS) consumption on physiological parameters, lipid profile, and microbiota of Wistar rats fed a high-fat diet (HF) or control diet (CT). FCS combined with a high-fat diet increased the fecal and cecal Bifidobacterium spp. population and decreased the cecal Escherichia coli population and intestinal Il1b mRNA level. Regardless of the diet type, FCS increased the serum high-density lipoprotein cholesterol (HDL-C); however, it did not affect body weight, food intake, low-density lipoprotein, triglycerides, fecal bile acids, and intestinal Il6 mRNA levels. The high-fat diet increased weight gain, hepatic cholesterol and triglycerides, fecal bile acids, and the fecal and cecal Lactobacillus spp. population, and reduced food intake, the fecal E. coli population, and intestinal Il6 mRNA level. The results suggest that FCS consumption exhibits positive health effects in rats fed a high-fat diet by increasing Bifidobacterium spp. population and HDL-C reverse cholesterol transport, and by reducing Il1b mRNA level. However, FCS administration at a dose of 0.39 g/100 g diet over an eight-week period was not effective in controlling food intake, and consequently, preventing weight gain in rats of high-fat diet-induced obesity model.Faculdade de Ciências da Saúde (FS)Departamento de Nutrição (FS NUT)Programa de Pós-Graduação em Nutrição Humanareponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_EffectFreeze-driedCoffee.pdfARTIGO_EffectFreeze-driedCoffee.pdfapplication/pdf1298707http://repositorio2.unb.br/jspui/bitstream/10482/47160/1/ARTIGO_EffectFreeze-driedCoffee.pdfe691586fd6225b4f1d045f62339d4a19MD51open accessLICENSElicense.txtlicense.txttext/plain102http://repositorio2.unb.br/jspui/bitstream/10482/47160/2/license.txtaed4704d04bb260d4decd80db311aaa5MD52open access10482/471602024-01-16 11:52:06.832open accessoai:repositorio.unb.br:10482/47160U3VibWlzc8OjbyBlZmV0aXZhZGEgZGUgYWNvcmRvIGNvbSBsaWNlbsOnYSBjb25jZWRpZGEgcGVsbyBhdXRvciBlL291IGRldGVudG9yIGRvcyBkaXJlaXRvcyBhdXRvcmFpcy4KRepositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2024-01-16T14:52:06Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| spellingShingle | Effect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats : impact on inflammatory response, lipid profile, and gut microbiota Cavalcanti, Marilia Hermes Dietas Café Bile Bifidobactérias Escherichia coli Obesidade Lactobacilos |
| status_str | publishedVersion |
| title | Effect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats : impact on inflammatory response, lipid profile, and gut microbiota |
| title_full | Effect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats : impact on inflammatory response, lipid profile, and gut microbiota |
| title_fullStr | Effect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats : impact on inflammatory response, lipid profile, and gut microbiota |
| title_full_unstemmed | Effect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats : impact on inflammatory response, lipid profile, and gut microbiota |
| title_short | Effect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats : impact on inflammatory response, lipid profile, and gut microbiota |
| title_sort | Effect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats : impact on inflammatory response, lipid profile, and gut microbiota |
| topic | Dietas Café Bile Bifidobactérias Escherichia coli Obesidade Lactobacilos |
| url | http://repositorio2.unb.br/jspui/handle/10482/47160 https://doi.org/10.1371/journal.pone.0262270 https://orcid.org/0000-0002-9826-6004 |