KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma : a systematic review
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| Autor principal: | |
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| Data de publicació: | 2023 |
| Altres autors: | , , , , |
| Format: | Article |
| Idioma: | eng |
| Font: | Repositório Institucional da UnB |
| Download full: | http://repositorio.unb.br/handle/10482/52463 https://doi.org/10.1002/hed.27597 https://orcid.org/0000-0002-5282-7785 https://orcid.org/0000-0001-6953-6901 https://orcid.org/0000-0001-6654-5239 https://orcid.org/0000-0003-0428-834X https://orcid.org/0000-0002-9782-3366 https://orcid.org/0000-0002-6272-6558 |
Sumari: | Background: The involvement of the KMT2 methyltransferase family in the pathogenesis of head and neck squamous cell carcinoma (HNSCC) remains elusive. Method: This study adhered to the PRISMA guidelines, employing a search strategy in the LIVIVO, PubMed, Scopus, Embase, Web of Science, and Google Scholar databases. The methodological quality of the studies was assessed by the Joanna Briggs Institute. Results: A total of 33 studies involving 4294 individuals with HNSCC were included in this review. The most important alteration was the high mutational frequency in the KMT2C and KMT2D genes, with reported cooccurrence. The expression of the KMT2D gene exhibited considerable heterogeneity across the studies, while limited data was available for the remaining genes. Conclusions: KMT2C and KMT2D genes seem to have tumor suppressor activities, with involvement of cell cycle inhibitors, regulating different pathways that can lead to tumor progression, disease aggressiveness, and DNA damage accumulation. |
| _version_ | 1871442284766035968 |
|---|---|
| author | Santos, Marcos Ezequiel da Silva |
| author2 | Abreu, Anna Karolina de Carvalho Silva, Fabio Willian Martins da Ferreira, Elaine Barros Reis, Paula Elaine Diniz dos Ramos, Doralina do Amaral Rabello |
| author2_role | author author author author author |
| author_browse | Abreu, Anna Karolina de Carvalho Ferreira, Elaine Barros Ramos, Doralina do Amaral Rabello Reis, Paula Elaine Diniz dos Santos, Marcos Ezequiel da Silva Silva, Fabio Willian Martins da |
| author_facet | Santos, Marcos Ezequiel da Silva Abreu, Anna Karolina de Carvalho Silva, Fabio Willian Martins da Ferreira, Elaine Barros Reis, Paula Elaine Diniz dos Ramos, Doralina do Amaral Rabello |
| author_role | author |
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| bitstream.url.fl_str_mv | http://repositorio.unb.br/bitstream/10482/52463/1/ARTIGO_KMT2%28MLL%29FamilyMethyltransferases.pdf http://repositorio.unb.br/bitstream/10482/52463/2/license.txt |
| collection | Repositório Institucional da UnB |
| dc.contributor.affiliation.pt_BR.fl_str_mv | University of Brasília, School of Medicine, Laboratory of Molecular Pathology of Cancer University of Brasília, School of Medicine, Laboratory of Molecular Pathology of Cancer University of Brasília, School of Medicine, Laboratory of Molecular Pathology of Cancer University of Brasília, School of Health Sciences, Interdisciplinary Laboratory of Applied Research on Clinical Practice in Oncology University of Brasília, School of Health Sciences, Interdisciplinary Laboratory of Applied Research on Clinical Practice in Oncology University of Brasília, School of Medicine, Laboratory of Molecular Pathology of Cancer |
| dc.contributor.author.fl_str_mv | Santos, Marcos Ezequiel da Silva Abreu, Anna Karolina de Carvalho Silva, Fabio Willian Martins da Ferreira, Elaine Barros Reis, Paula Elaine Diniz dos Ramos, Doralina do Amaral Rabello |
| dc.date.accessioned.fl_str_mv | 2025-09-18T15:07:24Z |
| dc.date.available.fl_str_mv | 2025-09-18T15:07:24Z |
| dc.date.issued.fl_str_mv | 2023-12-15 |
| dc.identifier.citation.fl_str_mv | SANTOS, Marcos Ezequiel da Silva. KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma: a systematic review. Head & Neck, v. 46, n. 2, p. 417-434, 2023. DOI: https://doi.org/10.1002/hed.27597. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/hed.27597. Acesso em: 03 jul. 2025. |
| dc.identifier.doi.pt_BR.fl_str_mv | https://doi.org/10.1002/hed.27597 |
| dc.identifier.orcid.pt_BR.fl_str_mv | https://orcid.org/0000-0002-5282-7785 https://orcid.org/0000-0001-6953-6901 https://orcid.org/0000-0001-6654-5239 https://orcid.org/0000-0003-0428-834X https://orcid.org/0000-0002-9782-3366 https://orcid.org/0000-0002-6272-6558 |
| dc.identifier.uri.fl_str_mv | http://repositorio.unb.br/handle/10482/52463 |
| dc.language.iso.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Wiley |
| dc.rights.driver.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
| dc.subject.keyword.pt_BR.fl_str_mv | Metiltransferases Carcinoma espinocelular Câncer de cabeça e pescoço Revisão sistemática |
| dc.title.pt_BR.fl_str_mv | KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma : a systematic review |
| dc.type.driver.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Background: The involvement of the KMT2 methyltransferase family in the pathogenesis of head and neck squamous cell carcinoma (HNSCC) remains elusive. Method: This study adhered to the PRISMA guidelines, employing a search strategy in the LIVIVO, PubMed, Scopus, Embase, Web of Science, and Google Scholar databases. The methodological quality of the studies was assessed by the Joanna Briggs Institute. Results: A total of 33 studies involving 4294 individuals with HNSCC were included in this review. The most important alteration was the high mutational frequency in the KMT2C and KMT2D genes, with reported cooccurrence. The expression of the KMT2D gene exhibited considerable heterogeneity across the studies, while limited data was available for the remaining genes. Conclusions: KMT2C and KMT2D genes seem to have tumor suppressor activities, with involvement of cell cycle inhibitors, regulating different pathways that can lead to tumor progression, disease aggressiveness, and DNA damage accumulation. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UNB_3cf343f00a897054010d710c00ad00cf |
| identifier_str_mv | SANTOS, Marcos Ezequiel da Silva. KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma: a systematic review. Head & Neck, v. 46, n. 2, p. 417-434, 2023. DOI: https://doi.org/10.1002/hed.27597. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/hed.27597. Acesso em: 03 jul. 2025. |
| instacron_str | UNB |
| institution | UNB |
| instname_str | Universidade de Brasília (UnB) |
| language | eng |
| network_acronym_str | UNB |
| network_name_str | Repositório Institucional da UnB |
| oai_identifier_str | oai:repositorio.unb.br:10482/52463 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher.none.fl_str_mv | Wiley |
| reponame_str | Repositório Institucional da UnB |
| repository.mail.fl_str_mv | repositorio@unb.br |
| repository.name.fl_str_mv | Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| repository_id_str | |
| spelling | Santos, Marcos Ezequiel da SilvaAbreu, Anna Karolina de CarvalhoSilva, Fabio Willian Martins daFerreira, Elaine BarrosReis, Paula Elaine Diniz dosRamos, Doralina do Amaral RabelloUniversity of Brasília, School of Medicine, Laboratory of Molecular Pathology of CancerUniversity of Brasília, School of Medicine, Laboratory of Molecular Pathology of CancerUniversity of Brasília, School of Medicine, Laboratory of Molecular Pathology of CancerUniversity of Brasília, School of Health Sciences, Interdisciplinary Laboratory of Applied Research on Clinical Practice in OncologyUniversity of Brasília, School of Health Sciences, Interdisciplinary Laboratory of Applied Research on Clinical Practice in OncologyUniversity of Brasília, School of Medicine, Laboratory of Molecular Pathology of Cancer2025-09-18T15:07:24Z2025-09-18T15:07:24Z2023-12-15SANTOS, Marcos Ezequiel da Silva. KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma: a systematic review. Head & Neck, v. 46, n. 2, p. 417-434, 2023. DOI: https://doi.org/10.1002/hed.27597. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/hed.27597. Acesso em: 03 jul. 2025.http://repositorio.unb.br/handle/10482/52463https://doi.org/10.1002/hed.27597https://orcid.org/0000-0002-5282-7785https://orcid.org/0000-0001-6953-6901https://orcid.org/0000-0001-6654-5239https://orcid.org/0000-0003-0428-834Xhttps://orcid.org/0000-0002-9782-3366https://orcid.org/0000-0002-6272-6558engWileyThis is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. © 2023 The Authors. Head & Neck published by Wiley Periodicals LLC.info:eu-repo/semantics/openAccessKMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma : a systematic reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMetiltransferasesCarcinoma espinocelularCâncer de cabeça e pescoçoRevisão sistemáticaBackground: The involvement of the KMT2 methyltransferase family in the pathogenesis of head and neck squamous cell carcinoma (HNSCC) remains elusive. Method: This study adhered to the PRISMA guidelines, employing a search strategy in the LIVIVO, PubMed, Scopus, Embase, Web of Science, and Google Scholar databases. The methodological quality of the studies was assessed by the Joanna Briggs Institute. Results: A total of 33 studies involving 4294 individuals with HNSCC were included in this review. The most important alteration was the high mutational frequency in the KMT2C and KMT2D genes, with reported cooccurrence. The expression of the KMT2D gene exhibited considerable heterogeneity across the studies, while limited data was available for the remaining genes. Conclusions: KMT2C and KMT2D genes seem to have tumor suppressor activities, with involvement of cell cycle inhibitors, regulating different pathways that can lead to tumor progression, disease aggressiveness, and DNA damage accumulation.Faculdade de Medicina (FM)Faculdade de Ciências da Saúde (FS)Departamento de Enfermagem (FS ENF)Programa de Pós-Graduação em Ciências MédicasPrograma de Pós-Graduação em Enfermagemreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_KMT2(MLL)FamilyMethyltransferases.pdfARTIGO_KMT2(MLL)FamilyMethyltransferases.pdfapplication/pdf1872659http://repositorio.unb.br/bitstream/10482/52463/1/ARTIGO_KMT2%28MLL%29FamilyMethyltransferases.pdfa2940f7d80cfe74842e7041adba695e1MD51open accessLICENSElicense.txtlicense.txttext/plain102http://repositorio.unb.br/bitstream/10482/52463/2/license.txtaed4704d04bb260d4decd80db311aaa5MD52open access10482/524632025-09-18 12:07:25.455open accessoai:repositorio.unb.br:10482/52463U3VibWlzc8OjbyBlZmV0aXZhZGEgZGUgYWNvcmRvIGNvbSBsaWNlbsOnYSBjb25jZWRpZGEgcGVsbyBhdXRvciBlL291IGRldGVudG9yIGRvcyBkaXJlaXRvcyBhdXRvcmFpcy4KRepositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2025-09-18T15:07:25Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| spellingShingle | KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma : a systematic review Santos, Marcos Ezequiel da Silva Metiltransferases Carcinoma espinocelular Câncer de cabeça e pescoço Revisão sistemática |
| status_str | publishedVersion |
| title | KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma : a systematic review |
| title_full | KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma : a systematic review |
| title_fullStr | KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma : a systematic review |
| title_full_unstemmed | KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma : a systematic review |
| title_short | KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma : a systematic review |
| title_sort | KMT2 (MLL) family of methyltransferases in head and neck squamous cell carcinoma : a systematic review |
| topic | Metiltransferases Carcinoma espinocelular Câncer de cabeça e pescoço Revisão sistemática |
| url | http://repositorio.unb.br/handle/10482/52463 https://doi.org/10.1002/hed.27597 https://orcid.org/0000-0002-5282-7785 https://orcid.org/0000-0001-6953-6901 https://orcid.org/0000-0001-6654-5239 https://orcid.org/0000-0003-0428-834X https://orcid.org/0000-0002-9782-3366 https://orcid.org/0000-0002-6272-6558 |