Long-lasting mnemotropic effect of substance P and its N-terminal fragment (SP1-7) on avoidance learning
Guardat en:
| Autor principal: | |
|---|---|
| Data de publicació: | 1997 |
| Altres autors: | , |
| Format: | Article |
| Idioma: | por |
| Font: | Repositório Institucional da UnB |
| Download full: | http://repositorio.unb.br/handle/10482/6713 https://dx.doi.org/10.1590/S0100-879X1997000200011 |
Sumari: | ABSTRACT |
| _version_ | 1871442273021984768 |
|---|---|
| author | Tomaz, Carlos Alberto Bezerra |
| author2 | Silva, A.C.F. Nogueira, Paulo José de Campos |
| author2_role | author author |
| author_browse | Nogueira, Paulo José de Campos Silva, A.C.F. Tomaz, Carlos Alberto Bezerra |
| author_facet | Tomaz, Carlos Alberto Bezerra Silva, A.C.F. Nogueira, Paulo José de Campos |
| author_role | author |
| bitstream.checksum.fl_str_mv | ed278395657225170fb5af15d993727b 7b60860db7ee2e38c65f8e939773fbe2 ad8cf7a6f22a38c2919c7ce45b7149ab 0f8ab2a63497d5d8d4acca820a8f230e 364e3497d73fd1bb955828c9c766f936 0f0dbe4641ada6830ae9883f1f819361 |
| bitstream.checksumAlgorithm.fl_str_mv | MD5 MD5 MD5 MD5 MD5 MD5 |
| bitstream.url.fl_str_mv | http://repositorio2.unb.br/jspui/bitstream/10482/6713/1/ARTIGO_Long-lastingMnemotropicEffect.pdf http://repositorio2.unb.br/jspui/bitstream/10482/6713/2/license_url http://repositorio2.unb.br/jspui/bitstream/10482/6713/3/license_text http://repositorio2.unb.br/jspui/bitstream/10482/6713/4/license_rdf http://repositorio2.unb.br/jspui/bitstream/10482/6713/5/license.txt http://repositorio2.unb.br/jspui/bitstream/10482/6713/6/ARTIGO_Long-lastingMnemotropicEffect.pdf.txt |
| collection | Repositório Institucional da UnB |
| dc.contributor.author.fl_str_mv | Tomaz, Carlos Alberto Bezerra Silva, A.C.F. Nogueira, Paulo José de Campos |
| dc.date.accessioned.fl_str_mv | 2011-02-01T19:55:22Z |
| dc.date.available.fl_str_mv | 2011-02-01T19:55:22Z |
| dc.date.issued.fl_str_mv | 1997 |
| dc.identifier.citation.fl_str_mv | TOMAZ, C.; SILVA, A. C. F.; NOGUEIRA, P. J. C. Long-lasting mnemotropic effect of substance P and its N-terminal fragment (SP1-7) on avoidance learning. Brazilian journal of medical and biological research, v. 30, n. 2, p. 231-233, 1997. Disponível em: <http://www.scielo.br/pdf/bjmbr/v30n2/2635c.pdf>. Acesso em: 4 jan. 2011. doi: 10.1590/S0100-879X1997000200011. |
| dc.identifier.doi.en.fl_str_mv | https://dx.doi.org/10.1590/S0100-879X1997000200011 |
| dc.identifier.uri.fl_str_mv | http://repositorio.unb.br/handle/10482/6713 |
| dc.language.iso.fl_str_mv | por |
| dc.rights.driver.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
| dc.subject.keyword.en.fl_str_mv | Substância P Memória de longa duração |
| dc.title.en.fl_str_mv | Long-lasting mnemotropic effect of substance P and its N-terminal fragment (SP1-7) on avoidance learning |
| dc.type.driver.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | ABSTRACT |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UNB_34ef4b767be21ee95fe65cec0f66d1aa |
| identifier_str_mv | TOMAZ, C.; SILVA, A. C. F.; NOGUEIRA, P. J. C. Long-lasting mnemotropic effect of substance P and its N-terminal fragment (SP1-7) on avoidance learning. Brazilian journal of medical and biological research, v. 30, n. 2, p. 231-233, 1997. Disponível em: <http://www.scielo.br/pdf/bjmbr/v30n2/2635c.pdf>. Acesso em: 4 jan. 2011. doi: 10.1590/S0100-879X1997000200011. |
| instacron_str | UNB |
| institution | UNB |
| instname_str | Universidade de Brasília (UnB) |
| language | por |
| network_acronym_str | UNB |
| network_name_str | Repositório Institucional da UnB |
| oai_identifier_str | oai:repositorio.unb.br:10482/6713 |
| publishDate | 1997 |
| publishDateSort | 1997 |
| reponame_str | Repositório Institucional da UnB |
| repository.mail.fl_str_mv | repositorio@unb.br |
| repository.name.fl_str_mv | Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| repository_id_str | |
| spelling | Tomaz, Carlos Alberto BezerraSilva, A.C.F.Nogueira, Paulo José de Campos2011-02-01T19:55:22Z2011-02-01T19:55:22Z1997TOMAZ, C.; SILVA, A. C. F.; NOGUEIRA, P. J. C. Long-lasting mnemotropic effect of substance P and its N-terminal fragment (SP1-7) on avoidance learning. Brazilian journal of medical and biological research, v. 30, n. 2, p. 231-233, 1997. Disponível em: <http://www.scielo.br/pdf/bjmbr/v30n2/2635c.pdf>. Acesso em: 4 jan. 2011. doi: 10.1590/S0100-879X1997000200011.http://repositorio.unb.br/handle/10482/6713https://dx.doi.org/10.1590/S0100-879X1997000200011ABSTRACTWe investigated the long-lasting effect of peripheral injection of the neuropeptide substance P (SP) and of some N- or C-terminal SP fragments (SPN and SPC, respectively) on retention test performance of avoidance learning. Male Wistar rats (220 to 280 g) were trained in an inhibitory step-down avoidance task and tested 24 h or 21 days later. Immediately after the training trial rats received an intraperitoneal injection of SP (50 µg/kg), SPN 1-7 (167 µg/kg) or SPC 7-11 (134 µg/kg). Control groups were injected with vehicle or SP 5 h after the training trial. The immediate post-training administration of SP and SPN, but not SPC, facilitated avoidance behavior in rats tested 24 h or 21 days later, i.e., the retention test latencies of the SP and SPN groups were significantly longer (P<0.05, Mann-Whitney U-test) during both training-test intervals. These observations suggest that the memory-enhancing effect of SP is long-lasting and that the amino acid sequence responsible for this effect is encoded by its N-terminal part.Long-lasting mnemotropic effect of substance P and its N-terminal fragment (SP1-7) on avoidance learninginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSubstância PMemória de longa duraçãoinfo:eu-repo/semantics/openAccessporreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_Long-lastingMnemotropicEffect.pdfARTIGO_Long-lastingMnemotropicEffect.pdfapplication/pdf170411http://repositorio2.unb.br/jspui/bitstream/10482/6713/1/ARTIGO_Long-lastingMnemotropicEffect.pdfed278395657225170fb5af15d993727bMD51open accessCC-LICENSElicense_urllicense_urltext/plain46http://repositorio2.unb.br/jspui/bitstream/10482/6713/2/license_url7b60860db7ee2e38c65f8e939773fbe2MD52open accesslicense_textlicense_textapplication/octet-stream18583http://repositorio2.unb.br/jspui/bitstream/10482/6713/3/license_textad8cf7a6f22a38c2919c7ce45b7149abMD53open accesslicense_rdflicense_rdfapplication/octet-stream21195http://repositorio2.unb.br/jspui/bitstream/10482/6713/4/license_rdf0f8ab2a63497d5d8d4acca820a8f230eMD54open accessLICENSElicense.txtlicense.txttext/plain1866http://repositorio2.unb.br/jspui/bitstream/10482/6713/5/license.txt364e3497d73fd1bb955828c9c766f936MD55open accessTEXTARTIGO_Long-lastingMnemotropicEffect.pdf.txtARTIGO_Long-lastingMnemotropicEffect.pdf.txtExtracted texttext/plain12365http://repositorio2.unb.br/jspui/bitstream/10482/6713/6/ARTIGO_Long-lastingMnemotropicEffect.pdf.txt0f0dbe4641ada6830ae9883f1f819361MD56open access10482/67132023-05-23 21:10:18.345open accessoai:repositorio.unb.br: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ório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-05-24T00:10:18Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| spellingShingle | Long-lasting mnemotropic effect of substance P and its N-terminal fragment (SP1-7) on avoidance learning Tomaz, Carlos Alberto Bezerra Substância P Memória de longa duração |
| status_str | publishedVersion |
| title | Long-lasting mnemotropic effect of substance P and its N-terminal fragment (SP1-7) on avoidance learning |
| title_full | Long-lasting mnemotropic effect of substance P and its N-terminal fragment (SP1-7) on avoidance learning |
| title_fullStr | Long-lasting mnemotropic effect of substance P and its N-terminal fragment (SP1-7) on avoidance learning |
| title_full_unstemmed | Long-lasting mnemotropic effect of substance P and its N-terminal fragment (SP1-7) on avoidance learning |
| title_short | Long-lasting mnemotropic effect of substance P and its N-terminal fragment (SP1-7) on avoidance learning |
| title_sort | Long-lasting mnemotropic effect of substance P and its N-terminal fragment (SP1-7) on avoidance learning |
| topic | Substância P Memória de longa duração |
| url | http://repositorio.unb.br/handle/10482/6713 https://dx.doi.org/10.1590/S0100-879X1997000200011 |