Desenvolvimento tecnológico de extratos vegetais padronizados a partir de Brosimum gaudichaudii Trécul (Moraceae)
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| Autor principal: | |
|---|---|
| Publication Date: | 2012 |
| Formato: | Master thesis |
| Idioma: | por |
| Fonte: | Repositório Institucional da UFG |
| Download full: | http://repositorio.bc.ufg.br/tede/handle/tede/13890 |
Resumo: | Brosimum gaudichaudii Trécul is a species belonging to the Moraceae, It is endemic to the Brazilian savana and is used in the treatment of vitiligo due to the presence of furocoumarins, psoralen and bergapten. This work aimed to the technological development of standardized plant extracts from the roots of B. gaudichaudii. The work began by characterizing the plant drug was obtained and then the liquid extracts (percolation) and dried (spray dryer), with a previous study of process optimization. The optimization study was performed by a 33 factorial design (Box-Behnken), which included the evaluation of factors, extraction time, particle size and alcohol degree. This step revealed that the optimum conditions for extraction of psoralen and bergapten in ultrasound time were 25 min, particle size (150-200µm) and alcohol degree between (55-60%). The extraction by percolation was necessary for 21 days, after which time the biochemical markers were depleted of plant drug. The liquid extract standardized had a density of 0.93 g / ml, 5.41% solids (w / w), pH 6.4 and 22% alcohol degree. The contents of furocoumarins were 1.1% (w / w) of psoralen and 2.94% (w / w) of bergapten. The stability study showed that psoralen and bergapten chemical markers are stable for the stability conditions studied. The spray drying conditions were optimized in the 100 ° C, 5 mL / min and 50%. The drying did not cause loss of psoralen bergapten. |
| _version_ | 1871426349729579008 |
|---|---|
| author | Martins, Frederico Severino |
| author_browse | Martins, Frederico Severino |
| author_facet | Martins, Frederico Severino |
| author_role | author |
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| bitstream.checksumAlgorithm.fl_str_mv | MD5 MD5 |
| bitstream.url.fl_str_mv | http://repositorio.bc.ufg.br/tede/bitstreams/dfcabd00-3dc3-4cd0-9053-8cabd8076dc2/download http://repositorio.bc.ufg.br/tede/bitstreams/9daff18f-812a-4567-9147-05ecbc1de8db/download |
| collection | Repositório Institucional da UFG |
| contributor_str_mv | Conceição, Edemilson Cardoso da Conceição, Edemilson Cardoso da Paula, Joelma Abadia Marciano de Fonseca, Yris Maria |
| dc.contributor.advisor1.fl_str_mv | Conceição, Edemilson Cardoso da |
| dc.contributor.author.fl_str_mv | Martins, Frederico Severino |
| dc.contributor.referee1.fl_str_mv | Conceição, Edemilson Cardoso da |
| dc.contributor.referee2.fl_str_mv | Paula, Joelma Abadia Marciano de |
| dc.contributor.referee3.fl_str_mv | Fonseca, Yris Maria |
| dc.date.accessioned.fl_str_mv | 2025-03-06T19:04:56Z |
| dc.date.available.fl_str_mv | 2025-03-06T19:04:56Z |
| dc.date.issued.fl_str_mv | 2012-08-10 |
| dc.identifier.citation.fl_str_mv | MARTINS, Frederico Severino. Desenvolvimento tecnológico de extratos vegetais padronizados a partir de Brosimum gaudichaudii Trécul (Moraceae). Orientador: Edemilson Cardoso da Conceição. 2011. 97 f. Dissertação (Mestrado em Ciências da Saúde) - Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, 2011. |
| dc.identifier.uri.fl_str_mv | http://repositorio.bc.ufg.br/tede/handle/tede/13890 |
| dc.language.iso.fl_str_mv | por |
| dc.publisher.country.fl_str_mv | Brasil |
| dc.publisher.department.fl_str_mv | Faculdade de Farmácia - FF (RMG) |
| dc.publisher.initials.fl_str_mv | UFG |
| dc.publisher.none.fl_str_mv | Universidade Federal de Goiás |
| dc.publisher.program.fl_str_mv | Programa de Pós-graduação em Ciências Farmacêuticas (FF) |
| dc.rights.driver.fl_str_mv | info:eu-repo/semantics/embargoedAccess |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
| dc.subject.cnpq.fl_str_mv | CIENCIAS BIOLOGICAS::FARMACOLOGIA |
| dc.subject.eng.fl_str_mv | Furanocumarins Psoralen Bergapten Spray dryer Standardized extracts |
| dc.subject.por.fl_str_mv | Furanocumarinas Psoraleno Bergapteno Spray dryer Extratos padronizados |
| dc.title.none.fl_str_mv | Desenvolvimento tecnológico de extratos vegetais padronizados a partir de Brosimum gaudichaudii Trécul (Moraceae) |
| dc.type.driver.fl_str_mv | info:eu-repo/semantics/masterThesis |
| dc.type.status.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Brosimum gaudichaudii Trécul is a species belonging to the Moraceae, It is endemic to the Brazilian savana and is used in the treatment of vitiligo due to the presence of furocoumarins, psoralen and bergapten. This work aimed to the technological development of standardized plant extracts from the roots of B. gaudichaudii. The work began by characterizing the plant drug was obtained and then the liquid extracts (percolation) and dried (spray dryer), with a previous study of process optimization. The optimization study was performed by a 33 factorial design (Box-Behnken), which included the evaluation of factors, extraction time, particle size and alcohol degree. This step revealed that the optimum conditions for extraction of psoralen and bergapten in ultrasound time were 25 min, particle size (150-200µm) and alcohol degree between (55-60%). The extraction by percolation was necessary for 21 days, after which time the biochemical markers were depleted of plant drug. The liquid extract standardized had a density of 0.93 g / ml, 5.41% solids (w / w), pH 6.4 and 22% alcohol degree. The contents of furocoumarins were 1.1% (w / w) of psoralen and 2.94% (w / w) of bergapten. The stability study showed that psoralen and bergapten chemical markers are stable for the stability conditions studied. The spray drying conditions were optimized in the 100 ° C, 5 mL / min and 50%. The drying did not cause loss of psoralen bergapten. |
| eu_rights_str_mv | embargoedAccess |
| format | masterThesis |
| id | UFG-2_3fcaf33d0965f847ff4b3d799cf1efd2 |
| identifier_str_mv | MARTINS, Frederico Severino. Desenvolvimento tecnológico de extratos vegetais padronizados a partir de Brosimum gaudichaudii Trécul (Moraceae). Orientador: Edemilson Cardoso da Conceição. 2011. 97 f. Dissertação (Mestrado em Ciências da Saúde) - Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, 2011. |
| instacron_str | UFG |
| institution | UFG |
| instname_str | Universidade Federal de Goiás (UFG) |
| language | por |
| network_acronym_str | UFG-2 |
| network_name_str | Repositório Institucional da UFG |
| oai_identifier_str | oai:repositorio.bc.ufg.br:tede/13890 |
| publishDate | 2012 |
| publishDateSort | 2012 |
| publisher.none.fl_str_mv | Universidade Federal de Goiás |
| reponame_str | Repositório Institucional da UFG |
| repository.mail.fl_str_mv | grt.bc@ufg.br |
| repository.name.fl_str_mv | Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
| repository_id_str | oai:repositorio.bc.ufg.br:tede/1234 |
| spelling | Conceição, Edemilson Cardoso daConceição, Edemilson Cardoso daPaula, Joelma Abadia Marciano deFonseca, Yris MariaMartins, Frederico Severino2025-03-06T19:04:56Z2025-03-06T19:04:56Z2012-08-10MARTINS, Frederico Severino. Desenvolvimento tecnológico de extratos vegetais padronizados a partir de Brosimum gaudichaudii Trécul (Moraceae). Orientador: Edemilson Cardoso da Conceição. 2011. 97 f. Dissertação (Mestrado em Ciências da Saúde) - Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, 2011.http://repositorio.bc.ufg.br/tede/handle/tede/13890Brosimum gaudichaudii Trécul is a species belonging to the Moraceae, It is endemic to the Brazilian savana and is used in the treatment of vitiligo due to the presence of furocoumarins, psoralen and bergapten. This work aimed to the technological development of standardized plant extracts from the roots of B. gaudichaudii. The work began by characterizing the plant drug was obtained and then the liquid extracts (percolation) and dried (spray dryer), with a previous study of process optimization. The optimization study was performed by a 33 factorial design (Box-Behnken), which included the evaluation of factors, extraction time, particle size and alcohol degree. This step revealed that the optimum conditions for extraction of psoralen and bergapten in ultrasound time were 25 min, particle size (150-200µm) and alcohol degree between (55-60%). The extraction by percolation was necessary for 21 days, after which time the biochemical markers were depleted of plant drug. The liquid extract standardized had a density of 0.93 g / ml, 5.41% solids (w / w), pH 6.4 and 22% alcohol degree. The contents of furocoumarins were 1.1% (w / w) of psoralen and 2.94% (w / w) of bergapten. The stability study showed that psoralen and bergapten chemical markers are stable for the stability conditions studied. The spray drying conditions were optimized in the 100 ° C, 5 mL / min and 50%. The drying did not cause loss of psoralen bergapten.Brosimum gaudichaudii Trécul é uma espécie pertencente à família Moraceae, endêmica do cerrado brasileiro e é utilizada no tratamento de vitiligo devido à presença das furanocumarinas, psoraleno e bergapteno. O presente trabalho teve como objetivo o desenvolvimento tecnológico de extratos vegetais padronizados a partir das raízes de B. gaudichaudii. O trabalho iniciou-se pela caracterização da droga vegetal e posteriormente obteve-se os extratos líquidos e secos padronizados.O estudo de otimização foi realizado a partir de um planejamento fatorial 33 (Box-Behnken), que contemplava a avaliação dos fatores: tempo de extração; tamanho de partícula; e graduação alcoólica. Essa etapa revelou que as condições ótimas para a extração do psoraleno e bergapteno em ultrasom eram : 25 min de extração , tamanho de partícula de (150-200µm) e teor alcoólico entre 55 a 60%. Para a extração por percolação foram necessários 21 dias, após esse tempo os marcadores químicos foram esgotados da droga vegetal.O extrato líquido padronizado apresentou densidade de 0,93 g/mL, teor de sólidos de 5,41 % (m/m), pH 6,4 e teor alcoólico de 22 % (v/v). Os teores de furanocumarinas foram de 1,1 %(m/m) de psoraleno e 2,94 %(m/m) de bergapteno.O estudo de estabilidade revelou que os marcadores químicos psoraleno e bergapteno, são estáveis para as condições de estabilidade estudada. As condições otimizadas para a secagem foram de 100 ºC para o ar de secagem, 5 mL/min para a vazão de extrato e 50 % de adjuvante de secagem.porUniversidade Federal de GoiásPrograma de Pós-graduação em Ciências Farmacêuticas (FF)UFGBrasilFaculdade de Farmácia - FF (RMG)FuranocumarinasPsoralenoBergaptenoSpray dryerExtratos padronizadosFuranocumarinsPsoralenBergaptenSpray dryerStandardized extractsCIENCIAS BIOLOGICAS::FARMACOLOGIADesenvolvimento tecnológico de extratos vegetais padronizados a partir de Brosimum gaudichaudii Trécul (Moraceae)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/embargoedAccessreponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.bc.ufg.br/tede/bitstreams/dfcabd00-3dc3-4cd0-9053-8cabd8076dc2/download8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALDissertação - Frederico Severino Martins - 2011.pdfDissertação - Frederico Severino Martins - 2011.pdfapplication/pdf14728646http://repositorio.bc.ufg.br/tede/bitstreams/9daff18f-812a-4567-9147-05ecbc1de8db/downloadadecd969c0a86d4215c2934d77e80513MD52tede/138902025-03-06 16:04:56.642restrictedoai:repositorio.bc.ufg.br:tede/13890http://repositorio.bc.ufg.br/tedeRepositório InstitucionalPUBhttps://repositorio.bc.ufg.br/tedeserver/oai/requestgrt.bc@ufg.bropendoar:oai:repositorio.bc.ufg.br:tede/12342025-03-06T19:04:56Repositório Institucional da UFG - Universidade Federal de Goiás (UFG)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 |
| spellingShingle | Desenvolvimento tecnológico de extratos vegetais padronizados a partir de Brosimum gaudichaudii Trécul (Moraceae) Martins, Frederico Severino Furanocumarinas Psoraleno Bergapteno Spray dryer Extratos padronizados Furanocumarins Psoralen Bergapten Spray dryer Standardized extracts CIENCIAS BIOLOGICAS::FARMACOLOGIA |
| status_str | publishedVersion |
| title | Desenvolvimento tecnológico de extratos vegetais padronizados a partir de Brosimum gaudichaudii Trécul (Moraceae) |
| title_full | Desenvolvimento tecnológico de extratos vegetais padronizados a partir de Brosimum gaudichaudii Trécul (Moraceae) |
| title_fullStr | Desenvolvimento tecnológico de extratos vegetais padronizados a partir de Brosimum gaudichaudii Trécul (Moraceae) |
| title_full_unstemmed | Desenvolvimento tecnológico de extratos vegetais padronizados a partir de Brosimum gaudichaudii Trécul (Moraceae) |
| title_short | Desenvolvimento tecnológico de extratos vegetais padronizados a partir de Brosimum gaudichaudii Trécul (Moraceae) |
| title_sort | Desenvolvimento tecnológico de extratos vegetais padronizados a partir de Brosimum gaudichaudii Trécul (Moraceae) |
| topic | Furanocumarinas Psoraleno Bergapteno Spray dryer Extratos padronizados Furanocumarins Psoralen Bergapten Spray dryer Standardized extracts CIENCIAS BIOLOGICAS::FARMACOLOGIA |
| url | http://repositorio.bc.ufg.br/tede/handle/tede/13890 |