Anestesia intravenosa total com cetamina-propofol ou cetamina-xilazina-egg em infusão contínua em asininos pré-medicados com xilazina
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| Datum vydání: | 2009 |
| Médium: | Master thesis |
| Jazyk: | por |
| Zdroj: | Repositório Institucional da UFG |
| Download full: | http://repositorio.bc.ufg.br/tede/handle/tde/398 |
Shrnutí: | The dissociative anesthesia was receiving more attention as the inhalation anesthesia based in cardiorespiratory and economic results in horses. However, there are few studies in donkeys (Equus asinus). The aim of this research was evaluate and compare the cardiorespiratory, metabolic and electrocardiographic effects of ketamine-propofol (KP) and ketamine-xilazine-EGG (GKX) total intravenous anesthesia in donkeys. Eight healthy adult donkeys were anesthetized twice with seven days interval between protocols. In both protocols, the animals were premedicated with 1.0 mg/kg of xylazine. The protocol KP was induced with 1.5 mg/kg of ketamine and a loading dose of propofol (0.5 mg/kg). The animals were maintained in constant rate infusion of ketamine (0.05 mg/kg/min) and propofol (0.15 mg/kg/min) during one hour. In GKX protocol, the animals were induced with diazepam (0.05 mg/kg) and ketamine (2.2 mg/kg). So, the animals were maintained in constant rate infusion (2 ml/kg/h) of a solution prepared with an association of 5% guaifenesin (100 mg/kg), ketamine (2.0 mg/ml) and xylazine (0.5 mg/ml). The quality of induction and recovery were assessed using scores (1-good; 2-regular; 3-poor) and measured cardiorespiratory, metabolic and electrocardiographic parameters before, during and after the anesthetic procedure. The results showed that the ketamine-propofol and ketamine-xylazine-EGG associations were satisfactory to anesthetized the donkeys, whereas seven anesthetic inductions were classified as good (score 1) in both protocols. The heart rate was statistic different between protocols since 15M moment. The mean arterial pressure decreased during the procedure in KP and GKX. There were no statistic differences between protocols in PaO2, PaCO2, LACv e LACa. The arterial glucose showed higher elevation in GKX and statistic difference at recovery. There were no statistic differences regarding CK and AST serum values. Concerning the electrocardiographic assessment, the protocols did not result in abnormalities on the length and amplitude of waves and complexes that could compromise the cardiac dynamics. In conclusion, propofol-ketamine and ketamine-xylazine-EGG associations can be successfully employed in asinines for the accomplishment of procedures without painful stimuli. The cardiorespiratory, metabolic and electrocardiographic changes observed in the present study were not sufficient to cause systemic distress in healthy animals |
| _version_ | 1871426344063074304 |
|---|---|
| author | COELHO, Cássia Maria Molinaro |
| author_browse | COELHO, Cássia Maria Molinaro |
| author_facet | COELHO, Cássia Maria Molinaro |
| author_role | author |
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| bitstream.checksumAlgorithm.fl_str_mv | MD5 MD5 |
| bitstream.url.fl_str_mv | http://repositorio.bc.ufg.br/tede/bitstreams/b3d30d57-20c8-4240-9e49-2e874aa36958/download http://repositorio.bc.ufg.br/tede/bitstreams/7a748738-6c99-4f9a-a508-c519ddfee49f/download |
| collection | Repositório Institucional da UFG |
| contributor_str_mv | SILVA, Luiz Antônio Franco da FIORAVANTI, Maria Clorinda Soares ALVES, Geraldo Eleno Silveira |
| dc.contributor.advisor-co1.fl_str_mv | FIORAVANTI, Maria Clorinda Soares |
| dc.contributor.advisor-co1Lattes.fl_str_mv | http://lattes.cnpq.br/8772502020076257 |
| dc.contributor.advisor-co2.fl_str_mv | ALVES, Geraldo Eleno Silveira |
| dc.contributor.advisor-co2Lattes.fl_str_mv | http://lattes.cnpq.br/2315947597632104 |
| dc.contributor.advisor1.fl_str_mv | SILVA, Luiz Antônio Franco da |
| dc.contributor.advisor1Lattes.fl_str_mv | http://lattes.cnpq.br/0446055905975647 |
| dc.contributor.author.fl_str_mv | COELHO, Cássia Maria Molinaro |
| dc.contributor.authorLattes.fl_str_mv | http://lattes.cnpq.br/1209397269710785 |
| dc.date.accessioned.fl_str_mv | 2014-07-29T14:46:49Z |
| dc.date.available.fl_str_mv | 2009-11-19 |
| dc.date.issued.fl_str_mv | 2009-06-26 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.citation.fl_str_mv | COELHO, Cássia Maria Molinaro. Total intravenous anesthesia using ketaminepropofol or ketamine-xylazine-egg in donkeys premedicated with xylazine. 2009. 105 f. Dissertação (Mestrado em Ciências Agrárias) - Universidade Federal de Goiás, Goiânia, 2009. |
| dc.identifier.uri.fl_str_mv | http://repositorio.bc.ufg.br/tede/handle/tde/398 |
| dc.language.iso.fl_str_mv | por |
| dc.publisher.country.fl_str_mv | BR |
| dc.publisher.department.fl_str_mv | Ciências Agrárias |
| dc.publisher.initials.fl_str_mv | UFG |
| dc.publisher.none.fl_str_mv | Universidade Federal de Goiás |
| dc.publisher.program.fl_str_mv | Doutorado em Ciência Animal |
| dc.rights.driver.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
| dc.subject.cnpq.fl_str_mv | CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::PATOLOGIA ANIMAL |
| dc.subject.eng.fl_str_mv | asinine, dissociative anesthesia, metabolites |
| dc.subject.por.fl_str_mv | jumentos, anestesia dissociativa, metabólitos |
| dc.title.alternative.eng.fl_str_mv | Total intravenous anesthesia using ketaminepropofol or ketamine-xylazine-egg in donkeys premedicated with xylazine |
| dc.title.por.fl_str_mv | Anestesia intravenosa total com cetamina-propofol ou cetamina-xilazina-egg em infusão contínua em asininos pré-medicados com xilazina |
| dc.type.driver.fl_str_mv | info:eu-repo/semantics/masterThesis |
| dc.type.status.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | The dissociative anesthesia was receiving more attention as the inhalation anesthesia based in cardiorespiratory and economic results in horses. However, there are few studies in donkeys (Equus asinus). The aim of this research was evaluate and compare the cardiorespiratory, metabolic and electrocardiographic effects of ketamine-propofol (KP) and ketamine-xilazine-EGG (GKX) total intravenous anesthesia in donkeys. Eight healthy adult donkeys were anesthetized twice with seven days interval between protocols. In both protocols, the animals were premedicated with 1.0 mg/kg of xylazine. The protocol KP was induced with 1.5 mg/kg of ketamine and a loading dose of propofol (0.5 mg/kg). The animals were maintained in constant rate infusion of ketamine (0.05 mg/kg/min) and propofol (0.15 mg/kg/min) during one hour. In GKX protocol, the animals were induced with diazepam (0.05 mg/kg) and ketamine (2.2 mg/kg). So, the animals were maintained in constant rate infusion (2 ml/kg/h) of a solution prepared with an association of 5% guaifenesin (100 mg/kg), ketamine (2.0 mg/ml) and xylazine (0.5 mg/ml). The quality of induction and recovery were assessed using scores (1-good; 2-regular; 3-poor) and measured cardiorespiratory, metabolic and electrocardiographic parameters before, during and after the anesthetic procedure. The results showed that the ketamine-propofol and ketamine-xylazine-EGG associations were satisfactory to anesthetized the donkeys, whereas seven anesthetic inductions were classified as good (score 1) in both protocols. The heart rate was statistic different between protocols since 15M moment. The mean arterial pressure decreased during the procedure in KP and GKX. There were no statistic differences between protocols in PaO2, PaCO2, LACv e LACa. The arterial glucose showed higher elevation in GKX and statistic difference at recovery. There were no statistic differences regarding CK and AST serum values. Concerning the electrocardiographic assessment, the protocols did not result in abnormalities on the length and amplitude of waves and complexes that could compromise the cardiac dynamics. In conclusion, propofol-ketamine and ketamine-xylazine-EGG associations can be successfully employed in asinines for the accomplishment of procedures without painful stimuli. The cardiorespiratory, metabolic and electrocardiographic changes observed in the present study were not sufficient to cause systemic distress in healthy animals |
| eu_rights_str_mv | openAccess |
| format | masterThesis |
| id | UFG-2_33ebb7a74adfb3c3eecab0bf06afda1e |
| identifier_str_mv | COELHO, Cássia Maria Molinaro. Total intravenous anesthesia using ketaminepropofol or ketamine-xylazine-egg in donkeys premedicated with xylazine. 2009. 105 f. Dissertação (Mestrado em Ciências Agrárias) - Universidade Federal de Goiás, Goiânia, 2009. |
| instacron_str | UFG |
| institution | UFG |
| instname_str | Universidade Federal de Goiás (UFG) |
| language | por |
| network_acronym_str | UFG-2 |
| network_name_str | Repositório Institucional da UFG |
| oai_identifier_str | oai:repositorio.bc.ufg.br:tde/398 |
| publishDate | 2009 |
| publishDateSort | 2009 |
| publisher.none.fl_str_mv | Universidade Federal de Goiás |
| reponame_str | Repositório Institucional da UFG |
| repository.mail.fl_str_mv | grt.bc@ufg.br |
| repository.name.fl_str_mv | Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
| repository_id_str | oai:repositorio.bc.ufg.br:tede/1234 |
| spelling | SILVA, Luiz Antônio Franco dahttp://lattes.cnpq.br/0446055905975647FIORAVANTI, Maria Clorinda Soareshttp://lattes.cnpq.br/8772502020076257ALVES, Geraldo Eleno Silveirahttp://lattes.cnpq.br/2315947597632104http://lattes.cnpq.br/1209397269710785COELHO, Cássia Maria Molinaro2014-07-29T14:46:49Z2009-11-192009-06-26COELHO, Cássia Maria Molinaro. Total intravenous anesthesia using ketaminepropofol or ketamine-xylazine-egg in donkeys premedicated with xylazine. 2009. 105 f. Dissertação (Mestrado em Ciências Agrárias) - Universidade Federal de Goiás, Goiânia, 2009.http://repositorio.bc.ufg.br/tede/handle/tde/398The dissociative anesthesia was receiving more attention as the inhalation anesthesia based in cardiorespiratory and economic results in horses. However, there are few studies in donkeys (Equus asinus). The aim of this research was evaluate and compare the cardiorespiratory, metabolic and electrocardiographic effects of ketamine-propofol (KP) and ketamine-xilazine-EGG (GKX) total intravenous anesthesia in donkeys. Eight healthy adult donkeys were anesthetized twice with seven days interval between protocols. In both protocols, the animals were premedicated with 1.0 mg/kg of xylazine. The protocol KP was induced with 1.5 mg/kg of ketamine and a loading dose of propofol (0.5 mg/kg). The animals were maintained in constant rate infusion of ketamine (0.05 mg/kg/min) and propofol (0.15 mg/kg/min) during one hour. In GKX protocol, the animals were induced with diazepam (0.05 mg/kg) and ketamine (2.2 mg/kg). So, the animals were maintained in constant rate infusion (2 ml/kg/h) of a solution prepared with an association of 5% guaifenesin (100 mg/kg), ketamine (2.0 mg/ml) and xylazine (0.5 mg/ml). The quality of induction and recovery were assessed using scores (1-good; 2-regular; 3-poor) and measured cardiorespiratory, metabolic and electrocardiographic parameters before, during and after the anesthetic procedure. The results showed that the ketamine-propofol and ketamine-xylazine-EGG associations were satisfactory to anesthetized the donkeys, whereas seven anesthetic inductions were classified as good (score 1) in both protocols. The heart rate was statistic different between protocols since 15M moment. The mean arterial pressure decreased during the procedure in KP and GKX. There were no statistic differences between protocols in PaO2, PaCO2, LACv e LACa. The arterial glucose showed higher elevation in GKX and statistic difference at recovery. There were no statistic differences regarding CK and AST serum values. Concerning the electrocardiographic assessment, the protocols did not result in abnormalities on the length and amplitude of waves and complexes that could compromise the cardiac dynamics. In conclusion, propofol-ketamine and ketamine-xylazine-EGG associations can be successfully employed in asinines for the accomplishment of procedures without painful stimuli. The cardiorespiratory, metabolic and electrocardiographic changes observed in the present study were not sufficient to cause systemic distress in healthy animalsA anestesia intravenosa total tem recebido maior destaque que a anestesia inalatória com base nos resultados cardiorrespiratórios e econômicos de diversos estudos em eqüinos. Entretanto, estudos em asininos (Equus asinus) ainda são poucos. O objetivo desta pesquisa foi avaliar e comparar dois protocolos de anestesia intravenosa total utilizando as associações cetamina-propofol (CP) e cetamina-xilazina-EGG (CXE) em asininos. Foram utilizados na pesquisa oito asininos adultos, anestesiados duas vezes com intervalo mínimo de sete dias entre cada anestesia. Em ambos os protocolos, os animais foram pré-medicados com 1,0 mg/kg de cloridrato de xilazina. No protocolo CP foi realizada a indução com 1,5 mg/kg de cetamina e 0,5 mg/kg de propofol, sendo a manutenção com infusão de 0,05 mg/kg/min de cetamina e 0,15 mg/kg/min de propofol. No protocolo CXE, foi realizada a indução com 0,05 mg/kg de diazepam e 2,2mg/kg de cetamina e a manutenção com solução preparada a partir de 100 mg/kg de EGG (5%), adicionado de 0,5 mg/ml de xilazina e 2,0 mg/ml de cetamina, infundida na taxa 2ml/kg/h. Avaliaram-se a qualidade de indução e recuperação anestésica, parâmetros cardiorrespiratórios, metabólicos e eletrocardiográficos antes, durante e após a anestesia. Os resultados demonstraram que a indução anestésica foi classificada como boa em sete animais no grupo CP e em seis animais, em CXE. Na recuperação anestésica, sete recuperações foram classificadas como boas no grupo CP e no CXE. A frequência cardíaca apresentou aumento significativo em CP a partir do momento 15M. A pressão arterial média diminuiu ao longo do procedimento em ambos os protocolos sem diferença estatística entre os grupos. A diminuição da frequência respiratória foi mais acentuada e significativa no protocolo CP. Não houve diferença significativa entre os protocolos na pressão parcial de gases sanguíneo arterial e concentração de lactato sanguíneo venoso e arterial. A glicose arterial apresentou maior aumento em CXE e diferença significativa entre os protocolos na recuperação anestésica. Não foram encontradas alterações relevantes na concentração da creatina quinase e aspartato aminotransferase. No exame eletrocardiográfico, não foram observados alterações na duração ou amplitude de ondas e complexos sugestivos de comprometimento cardíaco. Diante dos resultados, conclui-se que os protocolos CP e CXE não apresentaram efeitos cardiorrespiratórios, metabólicos e eletrocardiográficos capazes de prejudicar a homeostase dos animais utilizados no estudoapplication/pdfhttp://repositorio.bc.ufg.br/TEDE/retrieve/2877/dissertacao%20cassia%20coelho%20ciencia%20animal.pdf.jpgporUniversidade Federal de GoiásDoutorado em Ciência AnimalUFGBRCiências Agráriasjumentos, anestesia dissociativa, metabólitosasinine, dissociative anesthesia, metabolitesCNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::PATOLOGIA ANIMALAnestesia intravenosa total com cetamina-propofol ou cetamina-xilazina-egg em infusão contínua em asininos pré-medicados com xilazinaTotal intravenous anesthesia using ketaminepropofol or ketamine-xylazine-egg in donkeys premedicated with xylazineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGORIGINALdissertacao cassia coelho ciencia animal.pdfapplication/pdf870975http://repositorio.bc.ufg.br/tede/bitstreams/b3d30d57-20c8-4240-9e49-2e874aa36958/downloada367c1888c0904092050edba61da6c2eMD51THUMBNAILdissertacao cassia coelho ciencia animal.pdf.jpgdissertacao cassia coelho ciencia animal.pdf.jpgGenerated Thumbnailimage/jpeg1943http://repositorio.bc.ufg.br/tede/bitstreams/7a748738-6c99-4f9a-a508-c519ddfee49f/downloadcc73c4c239a4c332d642ba1e7c7a9fb2MD52tde/3982014-07-30 03:00:45.729open.accessoai:repositorio.bc.ufg.br:tde/398http://repositorio.bc.ufg.br/tedeRepositório InstitucionalPUBhttps://repositorio.bc.ufg.br/tedeserver/oai/requestgrt.bc@ufg.bropendoar:oai:repositorio.bc.ufg.br:tede/12342014-07-30T06:00:45Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
| spellingShingle | Anestesia intravenosa total com cetamina-propofol ou cetamina-xilazina-egg em infusão contínua em asininos pré-medicados com xilazina COELHO, Cássia Maria Molinaro jumentos, anestesia dissociativa, metabólitos asinine, dissociative anesthesia, metabolites CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::PATOLOGIA ANIMAL |
| status_str | publishedVersion |
| title | Anestesia intravenosa total com cetamina-propofol ou cetamina-xilazina-egg em infusão contínua em asininos pré-medicados com xilazina |
| title_full | Anestesia intravenosa total com cetamina-propofol ou cetamina-xilazina-egg em infusão contínua em asininos pré-medicados com xilazina |
| title_fullStr | Anestesia intravenosa total com cetamina-propofol ou cetamina-xilazina-egg em infusão contínua em asininos pré-medicados com xilazina |
| title_full_unstemmed | Anestesia intravenosa total com cetamina-propofol ou cetamina-xilazina-egg em infusão contínua em asininos pré-medicados com xilazina |
| title_short | Anestesia intravenosa total com cetamina-propofol ou cetamina-xilazina-egg em infusão contínua em asininos pré-medicados com xilazina |
| title_sort | Anestesia intravenosa total com cetamina-propofol ou cetamina-xilazina-egg em infusão contínua em asininos pré-medicados com xilazina |
| topic | jumentos, anestesia dissociativa, metabólitos asinine, dissociative anesthesia, metabolites CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::PATOLOGIA ANIMAL |
| url | http://repositorio.bc.ufg.br/tede/handle/tde/398 |