Characterization of a tetrameric proanthocyanidin in Stryphnodendron pulcherrimum and an overview on potential health benefits of condensed tannins via interaction with gut microbiota

• Main Author: Gomes, Paulo Wender P.
• Publication Date: 2023
• Other Authors: Gomes, Emilli Roberta S., Carvalho, Alice R.V., Mannochio-Russo, Helena, Leão, Tiago F. [UNESP], Reis, José Diogo E., de Sarges, Maria Rosilda V., Mardegan, Horrana A., Pamplona, Sônia das G.S.R., Y. e Silva, Consuelo Yumiko, da Silva, Milton N.
• Format: Article
• Language: eng
• Source: Repositório Institucional da UNESP
• Download full: http://dx.doi.org/10.1016/j.jff.2023.105801; https://hdl.handle.net/11449/300609
• topic: Barbatimão; Flavan-3-ols; Human gut; LC-MS/MS; Phytonutrition; Tannins

Stryphnodendron pulcherrimum is a plant found in the Brazilian Amazon and contains high content of catechin/(epi)catechin (flavan-3-ol) derivatives. The polymerization of this kind of flavan-3-ol generates condensed tannins, often associated to plant-based diets and gut microbiota. Thus, the discovery of condensed tannins from plants is a valuable approach once it enhances their availability from natural sources. Herein, we described a tetrameric condensed tannin (Molecular Mass 1,170 a.m.u.) tentatively identified for the first time in the barks from S. pulcherrimum. Condensed tannins-derived (flavan-3-ols units) are likely degraded in the gut, and their degradation products such as 3-hydroxyphenylacetic acid (OPAC), 3,4-dihydroxyphenylacetic acid (DHAA), 3-(3,4-dihydroxyphenyl)-propionic acid (DHPA), and 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone (DHPV) could present benefits to gut microbiome metabolism. Therefore, this observational study represents a new insight into S. pulcherrimum, its molecules, and their potential benefits to avoid different diseases and gut well-functional.