Lactobacillus reuteri associado a antibióticos no tratamento da periodontite em fumantes.

• Main Author: Silva, Beatriz Goulart [UNESP]
• Publication Date: 2020
• Format: Bachelor thesis
• Language: por
• Source: Repositório Institucional da UNESP
• Download full: http://hdl.handle.net/11449/213592
• topic: Periodontitis; Periodontite; Lactobacillus reuteri; Tabagismo; Antibiótico

The present randomized controlled clinical study aimed to evaluate the influence of systemic use of Lactobacillus reuteri isolated or associated with Amoxicillin and Metronidazole, as adjunct therapies to the mechanical treatment of periodontitis in smoking patients. Inclusion and exclusion criteria made it possible to select 34 patients who were randomly allocated into groups, where patients were subjected to one of the following treatments: Group PRO (N=17), the patients were submitted to a single session of scaling and root planning (SRP), using ultrasound and manual curettes followed by systemic administration of Lactobacillus reuteri chewable tablets (2x / day / 21 days); Group ANT+PRO (N=17), the patients were submitted to a single session of SRP, using ultrasound and manual curettes, associated with systemic administration of amoxicillin (500 mg) and metronidazole (400 mg) every 8 hours, for 7 days, and after an interval of 7 days, the treatment with Lactobacillus reuteri (2x / day / 21 days) was started. Were evaluated the clinical parameters of: visible plaque index (VPI), depth on probing (DP), bleeding on probing (BP), level of clinical insertion (LCI) and gingival recession (GR), at six sites of all teeth at baseline and 90 days after SRP treatment. Data in percentage of reduction of residual pockets (DP > 4 mm) with BP were also assessed. The results of the clinical analysis revealed that at 90 days there was improvement in both groups in the parameters of BP, VPI and residual pockets compared to baseline, while in the group ANT+PRO there was also a reduction in DP and insertion gain (p<0,05). Both groups showed a reduction in DP and in the number of sites with moderate pockets. Only the group ANT+PRO showed a significant reduction in the number of deep pockets and greater reduction of DP of deep pockets at 90 days after treatment. In conclusion both adjunct therapies were effective in treatment of periodontitis in smokers, however, the combined use of Amoxicillin and Metronidazole followed by the ingestion of Lactobacillus reuteri, presented additional clinical benefits in comparation to the isolated use of Lactobacillus reuteri.