Pyoderma Gangrenosum with Oral Involvement and Multidisciplinary Management

• Main Author: de Souza Camargo, Héric [UNESP]
• Publication Date: 2025
• Other Authors: da Silva Nunes, Carolina [UNESP], Navarro, Claudia Maria [UNESP], Massucato, Elaine Maria Sgavioli [UNESP], Gabrielli, Marisa Aparecida Cabrini [UNESP], Filho, Valfrido Antonio Pereira [UNESP], Bufalino, Andreia [UNESP]
• Format: Article
• Language: eng
• Source: Repositório Institucional da UNESP
• Download full: http://dx.doi.org/10.1007/s12663-024-02218-0; https://hdl.handle.net/11449/308066
• topic: Inflammatory bowel disease; Pioderma gangrenosum; Total colectomy

Introduction: Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis often associated with inflammatory bowel disease. Case report: We present a case of PG affecting the oral mucosa in a 31-year-old female with ulcerative colitis, necessitating total colectomy due to aggressive lesion progression. Despite initial adalimumab treatment, the lesions persisted, prompting a multidisciplinary approach. Following surgical intervention, including total colectomy and microvascularized graft with a forearm flap, the patient remained recurrence-free during a seven-year follow-up. Conclusion: This case underscores the complexity of PG and highlights the efficacy of a comprehensive therapeutic approach, emphasizing the importance of individualized management strategies in severe cases.