Sensitivity profile of blood culture isolates in a clinical analysis laboratory, Fortaleza, CE

• Main Author: Alves Filho, André Luis
• Publication Date: 2022
• Other Authors: Medeiros, Alexander Amaral, Calixto Marques, Francisco Wallyson, Costa, Cecilia Leite
• Format: Article
• Language: por; eng
• Source: Revista de Epidemiologia e Controle de Infecção
• DOI: 10.17058/reci.v12i3.16822
• Download full: https://online.unisc.br/seer/index.php/epidemiologia/article/view/16822
• topic: Bacteremia; Hemocultura; Resistência Bacteriana; Perfil de Sensibilidade.

Background and objectives: bacteremia is defined from the presence of bacteria in the bloodstream. Its clinical importance is associated with the high morbidity and mortality rate in the world. In severe cases, it can culminate in sepsis, with a constant increase in cases in Brazil. Therefore, this study aims to assess the main bacterial isolates in blood cultures and a possible change in their sensitivity profiles in a clinical analysis laboratory in Fortaleza, Ceará. Methods: an epidemiological, descriptive, retrospective study was carried out, with a quantitative approach of positive blood cultures, seeking to assess the main isolated microorganisms and their sensitivity profiles. The data used were obtained from the laboratory system through the EpiCenter® software, from January 2019 to December 2020. Statistical analysis was performed using the Graphpad 7.0 software. Results: 840 microorganisms were identified from blood cultures, and the main ones were E. coli, K. pneumoniae, P. aeruginosa, S. epidermidis, S. aureus and S. haemolyticus. Some isolates show a change in the sensitivity profile, such as K. pneumoniae and P. aeruginosa, showing an increase in sensitivity to carbapenems and cephalosporins, while S. epidermidis showed a decrease in sensitivity to minocycline in the comparison between years 2019 and 2020.Conclusion: clinical isolates from blood cultures showed a change in the sensitivity profile between 2019 and 2020, taking into account that, for K. pneumoniae, P. aeruginosa, this change resulted in an increase in sensitivity, with an increase in resistance in S. epidermidis isolates.