Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI

Detalhes bibliográficos
Autor(a) principal: Bock, Nicholas A.
Data de Publicação: 2008
Outros Autores: Paiva, Fernando F., Nascimento, George Carlos do, Newman, John D., Silva, Afonso C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
dARK ID: ark:/41046/001300000nggh
Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/29724
Resumo: Manganese overexposure in non-human primates and humans causes a neurodegenerative disorder called manganism thought to be related to an accumulation of the metal in the basal ganglia. Here, we assess changes in the concentration of manganese in regions of the brain of a non-human primate (the common marmoset, Callithrix jacchus) following four systemic injections of 30 mg/kg MnCl2 H2O in the tail vein using T1-weighted magnetic resonance imaging (MRI) and compare these to changes in the rat following the same exposure route and dose. The doses were spaced 48 h apart and we imaged the animals 48 h after the final dose. We find that marmosets have significantly larger T1-weighted image enhancements in regions of the brain compared to rats, notably in the basal ganglia and the visual cortex. To confirm this difference across species reflects actual differences in manganese concentrations and not variations in the MRI properties of manganese, we measured the longitudinal relaxivity of manganese (χ1) in the in vivo brain and found no significant species' difference. The high manganese uptake in the marmoset basal ganglia and visual cortex can be explained by CSF-brain transport from the large lateral ventricles and we confirm this route of uptake with time-course MRI during a tail-vein infusion of manganese. There is also high uptake in the substructures of the hippocampus that are adjacent to the ventricles. The large manganese accumulation in these structures on overexposure may be common to all primates, including humans
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spelling Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRIMarmosetMagnetic resonance imagingRatBrainManganeseManganese overexposure in non-human primates and humans causes a neurodegenerative disorder called manganism thought to be related to an accumulation of the metal in the basal ganglia. Here, we assess changes in the concentration of manganese in regions of the brain of a non-human primate (the common marmoset, Callithrix jacchus) following four systemic injections of 30 mg/kg MnCl2 H2O in the tail vein using T1-weighted magnetic resonance imaging (MRI) and compare these to changes in the rat following the same exposure route and dose. The doses were spaced 48 h apart and we imaged the animals 48 h after the final dose. We find that marmosets have significantly larger T1-weighted image enhancements in regions of the brain compared to rats, notably in the basal ganglia and the visual cortex. To confirm this difference across species reflects actual differences in manganese concentrations and not variations in the MRI properties of manganese, we measured the longitudinal relaxivity of manganese (χ1) in the in vivo brain and found no significant species' difference. The high manganese uptake in the marmoset basal ganglia and visual cortex can be explained by CSF-brain transport from the large lateral ventricles and we confirm this route of uptake with time-course MRI during a tail-vein infusion of manganese. There is also high uptake in the substructures of the hippocampus that are adjacent to the ventricles. The large manganese accumulation in these structures on overexposure may be common to all primates, including humansElsevier2020-07-24T18:15:48Z2020-07-24T18:15:48Z2008-03-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBOCK, N.A.; PAIVA, F.F.; NASCIMENTO, G.C.; NEWMAN,J.D.; SILVA, A.C.. Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI.. Brain Research, v. 1198, p. 160-170, 2008. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0006899307030326?via%3Dihub. Acesso em: 21 jul. 2020. https://doi.org/10.1016/j.brainres.2007.12.0650006-8993https://repositorio.ufrn.br/jspui/handle/123456789/2972410.1016/j.brainres.2007.12.065ark:/41046/001300000ngghBock, Nicholas A.Paiva, Fernando F.Nascimento, George Carlos doNewman, John D.Silva, Afonso C.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccess2023-01-26T18:40:59Zoai:repositorio.ufrn.br:123456789/29724Repositório InstitucionalPUBhttp://repositorio.ufrn.br/oai/repositorio@bczm.ufrn.bropendoar:2023-01-26T18:40:59Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.none.fl_str_mv Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI
title Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI
spellingShingle Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI
Bock, Nicholas A.
Marmoset
Magnetic resonance imaging
Rat
Brain
Manganese
title_short Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI
title_full Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI
title_fullStr Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI
title_full_unstemmed Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI
title_sort Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI
author Bock, Nicholas A.
author_facet Bock, Nicholas A.
Paiva, Fernando F.
Nascimento, George Carlos do
Newman, John D.
Silva, Afonso C.
author_role author
author2 Paiva, Fernando F.
Nascimento, George Carlos do
Newman, John D.
Silva, Afonso C.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Bock, Nicholas A.
Paiva, Fernando F.
Nascimento, George Carlos do
Newman, John D.
Silva, Afonso C.
dc.subject.por.fl_str_mv Marmoset
Magnetic resonance imaging
Rat
Brain
Manganese
topic Marmoset
Magnetic resonance imaging
Rat
Brain
Manganese
description Manganese overexposure in non-human primates and humans causes a neurodegenerative disorder called manganism thought to be related to an accumulation of the metal in the basal ganglia. Here, we assess changes in the concentration of manganese in regions of the brain of a non-human primate (the common marmoset, Callithrix jacchus) following four systemic injections of 30 mg/kg MnCl2 H2O in the tail vein using T1-weighted magnetic resonance imaging (MRI) and compare these to changes in the rat following the same exposure route and dose. The doses were spaced 48 h apart and we imaged the animals 48 h after the final dose. We find that marmosets have significantly larger T1-weighted image enhancements in regions of the brain compared to rats, notably in the basal ganglia and the visual cortex. To confirm this difference across species reflects actual differences in manganese concentrations and not variations in the MRI properties of manganese, we measured the longitudinal relaxivity of manganese (χ1) in the in vivo brain and found no significant species' difference. The high manganese uptake in the marmoset basal ganglia and visual cortex can be explained by CSF-brain transport from the large lateral ventricles and we confirm this route of uptake with time-course MRI during a tail-vein infusion of manganese. There is also high uptake in the substructures of the hippocampus that are adjacent to the ventricles. The large manganese accumulation in these structures on overexposure may be common to all primates, including humans
publishDate 2008
dc.date.none.fl_str_mv 2008-03-10
2020-07-24T18:15:48Z
2020-07-24T18:15:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv BOCK, N.A.; PAIVA, F.F.; NASCIMENTO, G.C.; NEWMAN,J.D.; SILVA, A.C.. Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI.. Brain Research, v. 1198, p. 160-170, 2008. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0006899307030326?via%3Dihub. Acesso em: 21 jul. 2020. https://doi.org/10.1016/j.brainres.2007.12.065
0006-8993
https://repositorio.ufrn.br/jspui/handle/123456789/29724
10.1016/j.brainres.2007.12.065
dc.identifier.dark.fl_str_mv ark:/41046/001300000nggh
identifier_str_mv BOCK, N.A.; PAIVA, F.F.; NASCIMENTO, G.C.; NEWMAN,J.D.; SILVA, A.C.. Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI.. Brain Research, v. 1198, p. 160-170, 2008. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0006899307030326?via%3Dihub. Acesso em: 21 jul. 2020. https://doi.org/10.1016/j.brainres.2007.12.065
0006-8993
10.1016/j.brainres.2007.12.065
ark:/41046/001300000nggh
url https://repositorio.ufrn.br/jspui/handle/123456789/29724
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
instname:Universidade Federal do Rio Grande do Norte (UFRN)
instacron:UFRN
instname_str Universidade Federal do Rio Grande do Norte (UFRN)
instacron_str UFRN
institution UFRN
reponame_str Repositório Institucional da UFRN
collection Repositório Institucional da UFRN
repository.name.fl_str_mv Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)
repository.mail.fl_str_mv repositorio@bczm.ufrn.br
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