Efeito do extrato de Pleurotus ostreatus sobre a glicemia de camundongos fêmeas.

• Main Author: Silveira, Taís Köpp da
• Publication Date: 2022
• Format: Master thesis
• Language: por
• Source: Repositório Institucional da UFPel - Guaiaca
• Download full: http://guaiaca.ufpel.edu.br/handle/prefix/8638
• topic: Resistência insulínica; Toxicidade subcrônica; Glicemia; Cogumelos; Toxicidade aguda; Insulin resistance; Subchronic toxicity; Blood glucose; Mushrooms; Acute toxicity; CNPQ::CIENCIAS DA SAUDE::NUTRICAO

Studies that use natural compounds as an adjuvant in the treatment and/or prevention of non-communicable chronic diseases have been increasing. Mushrooms have several pharmacological properties, such as the hypoglycemic property, capable of increasing insulin sensitivity. Insulin is an anabolic hormone responsible for lowering blood glucose levels by internalizing glucose into cells. When there is an impaired response to this action, insulin resistance occurs. Therefore, the aim of the present study was to evaluate the action of Pleurotus ostreatus extract on the blood glucose of healthy female mice. As a starting point, the acute toxicity of the P. ostreatus extract in 5 Wistar rats was analyzed. After verifying that there were no signs of acute toxicity, experiment 2 was carried out. For this, 32 female C57BL/6 mice with approximately 60 days were used. These were divided into four groups: Control; P. ostreatus 500mg/Kg; P. ostreatus 1000mg/Kg P. ostreatus 2000mg/Kg, treated daily for 28 days. Doses of 500 and 2000mg/Kg were more effetive in increasing insulin sensitivity. No signs of subchronic toxicity were presented. Therefore, the mushroom of the genus Pleurotus ostreatus shows promise in improving insulin resistance, showing great potential as an adjuvant in the prevention/treatment of chronic diseases such as type 2 diabetes mellitus.