Subacute toxicity assessment of annatto in rat

Bibliographic Details
Main Author: Bautista, Ana Rita Pedreira Lapa
Publication Date: 2004
Other Authors: Moreira, E. L. T., Batista, Márcio Santos, Miranda, Maria da Pureza Spínola, Gomes, I. C. S.
Format: Article
Language: eng
Source: Repositório Institucional da UFBA
Download full: http://www.repositorio.ufba.br/ri/handle/ri/7525
Summary: Acesso Aberto
id UFBA-2_9d96ef5b8a4627e8812306fd9c1efdbe
oai_identifier_str oai:repositorio.ufba.br:ri/7525
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Bautista, Ana Rita Pedreira LapaMoreira, E. L. T.Batista, Márcio SantosMiranda, Maria da Pureza SpínolaGomes, I. C. S.Bautista, Ana Rita Pedreira LapaMoreira, E. L. T.Batista, Márcio SantosMiranda, Maria da Pureza SpínolaGomes, I. C. S.2012-12-14T11:59:01Z20040278-6915http://www.repositorio.ufba.br/ri/handle/ri/7525v. 42, n. 4Acesso AbertoIncreased human use of annatto (Bixa orellana L), a red yellow food colorant, demands generation of toxicity data. The toxic effects of annatto powder (bixin 27%) have been assessed following administration of a subacute regimen (4 weeks, 20 doses) in Wistar male and female rats. A full study with three dose levels was considered unnecessary since no sign of toxicity had been noted in a preliminary experiment with 1000 mg/kg body weight/day as was recommended by the OECD guideline. In this study, annatto administered by gavage at a dose level of 2000 mg/kg/day decreased male body weight gain, but had no effect on either food intake or food conversion efficiency. Haematological and plasma biochemical examination as well necropsy performed at the end of administration (29th day) and observation (43rd day) periods revealed no alterations related with annatto administration. Kidney apoptosis occurred in 20% treated female rats in restricted areas without proliferation or tubular segments modification. The precise nature of apoptosis was not investigated in the present study. These findings suggest that annatto was no toxic to the rat.Elservierhttp://dx.doi.org/10.1016/j.fct.2003.11.007reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBABixa orellanaAnnattoBixinFood colorSubacute toxicitySubacute toxicity assessment of annatto in ratFood and Chemical Toxicologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL1-s2.0-S0278691503003442-main.pdf1-s2.0-S0278691503003442-main.pdfapplication/pdf172277https://repositorio.ufba.br/bitstream/ri/7525/1/1-s2.0-S0278691503003442-main.pdfddfa4023851089fe3ac7b94fceae1c35MD51open accessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7525/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52open accessTEXT1-s2.0-S0278691503003442-main.pdf.txt1-s2.0-S0278691503003442-main.pdf.txtExtracted texttext/plain19176https://repositorio.ufba.br/bitstream/ri/7525/3/1-s2.0-S0278691503003442-main.pdf.txt3eaa71e656a5c0b348bbc0105f13253aMD53metadata only accessri/75252025-08-11 13:29:28.441open accessoai:repositorio.ufba.br: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Repositório InstitucionalPUBhttps://repositorio.ufba.br/oai/requestrepositorio@ufba.bropendoar:19322025-08-11T16:29:28Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Subacute toxicity assessment of annatto in rat
dc.title.alternative.pt_BR.fl_str_mv Food and Chemical Toxicology
title Subacute toxicity assessment of annatto in rat
spellingShingle Subacute toxicity assessment of annatto in rat
Bautista, Ana Rita Pedreira Lapa
Bixa orellana
Annatto
Bixin
Food color
Subacute toxicity
title_short Subacute toxicity assessment of annatto in rat
title_full Subacute toxicity assessment of annatto in rat
title_fullStr Subacute toxicity assessment of annatto in rat
title_full_unstemmed Subacute toxicity assessment of annatto in rat
title_sort Subacute toxicity assessment of annatto in rat
author Bautista, Ana Rita Pedreira Lapa
author_facet Bautista, Ana Rita Pedreira Lapa
Moreira, E. L. T.
Batista, Márcio Santos
Miranda, Maria da Pureza Spínola
Gomes, I. C. S.
author_role author
author2 Moreira, E. L. T.
Batista, Márcio Santos
Miranda, Maria da Pureza Spínola
Gomes, I. C. S.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Bautista, Ana Rita Pedreira Lapa
Moreira, E. L. T.
Batista, Márcio Santos
Miranda, Maria da Pureza Spínola
Gomes, I. C. S.
Bautista, Ana Rita Pedreira Lapa
Moreira, E. L. T.
Batista, Márcio Santos
Miranda, Maria da Pureza Spínola
Gomes, I. C. S.
dc.subject.por.fl_str_mv Bixa orellana
Annatto
Bixin
Food color
Subacute toxicity
topic Bixa orellana
Annatto
Bixin
Food color
Subacute toxicity
description Acesso Aberto
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2012-12-14T11:59:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7525
dc.identifier.issn.none.fl_str_mv 0278-6915
dc.identifier.number.pt_BR.fl_str_mv v. 42, n. 4
identifier_str_mv 0278-6915
v. 42, n. 4
url http://www.repositorio.ufba.br/ri/handle/ri/7525
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elservier
publisher.none.fl_str_mv Elservier
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.fct.2003.11.007
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/7525/1/1-s2.0-S0278691503003442-main.pdf
https://repositorio.ufba.br/bitstream/ri/7525/2/license.txt
https://repositorio.ufba.br/bitstream/ri/7525/3/1-s2.0-S0278691503003442-main.pdf.txt
bitstream.checksum.fl_str_mv ddfa4023851089fe3ac7b94fceae1c35
1b89a9a0548218172d7c829f87a0eab9
3eaa71e656a5c0b348bbc0105f13253a
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv repositorio@ufba.br
_version_ 1847338977101611008

Similar Items