Impacto das infecções maternas crônicas: associações entre a soropositividade materna para anticorpos IgG contra Toxoplasma gondii com restrição no crescimento fetal e efeitos no neurodesenvolvimento infantil

Detalhes bibliográficos
Autor(a) principal: Martinez, Victor Otero
Data de Publicação: 2024
Tipo de documento: Tese
Idioma: por
Título da fonte: Repositório Institucional da UFBA
Texto Completo: https://repositorio.ufba.br/handle/ri/41452
Resumo: Este trabalho faz parte de um estudo amplo, denominado DSAN-12m (Determinantes socioambientais do neurodesenvolvimento de crianças aos 12 meses: Um estudo longitudinal no Recôncavo Baiano), cujo objetivo é investigar os determinantes socioambientais do neurodesenvolvimento de crianças aos 12 meses de idade em uma coorte de nascimentos no Recôncavo Baiano. Na presente tese foram avaliados o estado da arte atual quanto às relações entre a ativação imunológica materna, doenças infecciosas crônicas/latentes pré-natais e o neurodesenvolvimento. Além disso, foram elaborados dois manuscritos originais, que visaram investigar o impacto de infecções durante o período gestacional, particularmente quando não há evidencias de doença aguda, no crescimento fetal ao nascimento e no neurodesenvolvimento infantil os 12 meses de idade. Para melhor organização, o texto foi dividido em um manuscrito de revisão, que apresenta o referencial teórico e sistematiza as publicações sobre o tema da tese. Em seguida, são apresentados dois manuscritos originais, seguidos por considerações finais, a fim de manter a unidade do trabalho. O primeiro manuscrito, intitulado “Impact of chronic toxoplasmosis in pregnancy: association between maternal seropositivity for Toxoplasma gondii IgG antibodies and fetal growth restriction”, investigou as relações entre a prevalência de anticorpos específicos em gestantes e alterações no desenvolvimento fetal ao nascimento. Destaca-se que este manuscrito foi publicado no periódico ‘Parasitology Research’ (ISSN: 1432-1955, Fator de impacto: 1,8) em dezembro de 2023 (APÊNDICE E). O segundo manuscrito, com o título “Impact of Chronic Toxoplasmosis in Pregnancy: Association between maternal IgG antibodies against Toxoplasma gondii and neurocognitive development effects”, explorou a associação entre a prevalência de anticorpos específicos em gestantes com alterações no neurodesenvolvimento de seus filhos aos 12 meses de idade. Esse manuscrito está formatado de acordo com as normas do periódico ‘Parasitology Research’ e será submetido para publicação após as correções sugeridas pela banca. Por fim, estão as considerações finais e as perspectivas futuras, integrando os resultados desta tese e dos demais fatores determinantes socioambientais que têm efeito adverso no neurodesenvolvimento infantil nesta coorte de nascimento realizada no Recôncavo Baiano, o estudo DSAN-12m.
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spelling 2025-03-16T02:08:05Z2025-03-16T02:08:05Z2024-12-06Martinez, Victor Otero. Impacto das infecções maternas crônicas: associações entre a soropositividade materna para anticorpos IgG contra Toxoplasma gondii com restrição no crescimento fetal e efeitos no neuro desenvolvimento infantil / Victor Otero Martinez. - 2024. 114 f.: il.https://repositorio.ufba.br/handle/ri/41452Este trabalho faz parte de um estudo amplo, denominado DSAN-12m (Determinantes socioambientais do neurodesenvolvimento de crianças aos 12 meses: Um estudo longitudinal no Recôncavo Baiano), cujo objetivo é investigar os determinantes socioambientais do neurodesenvolvimento de crianças aos 12 meses de idade em uma coorte de nascimentos no Recôncavo Baiano. Na presente tese foram avaliados o estado da arte atual quanto às relações entre a ativação imunológica materna, doenças infecciosas crônicas/latentes pré-natais e o neurodesenvolvimento. Além disso, foram elaborados dois manuscritos originais, que visaram investigar o impacto de infecções durante o período gestacional, particularmente quando não há evidencias de doença aguda, no crescimento fetal ao nascimento e no neurodesenvolvimento infantil os 12 meses de idade. Para melhor organização, o texto foi dividido em um manuscrito de revisão, que apresenta o referencial teórico e sistematiza as publicações sobre o tema da tese. Em seguida, são apresentados dois manuscritos originais, seguidos por considerações finais, a fim de manter a unidade do trabalho. O primeiro manuscrito, intitulado “Impact of chronic toxoplasmosis in pregnancy: association between maternal seropositivity for Toxoplasma gondii IgG antibodies and fetal growth restriction”, investigou as relações entre a prevalência de anticorpos específicos em gestantes e alterações no desenvolvimento fetal ao nascimento. Destaca-se que este manuscrito foi publicado no periódico ‘Parasitology Research’ (ISSN: 1432-1955, Fator de impacto: 1,8) em dezembro de 2023 (APÊNDICE E). O segundo manuscrito, com o título “Impact of Chronic Toxoplasmosis in Pregnancy: Association between maternal IgG antibodies against Toxoplasma gondii and neurocognitive development effects”, explorou a associação entre a prevalência de anticorpos específicos em gestantes com alterações no neurodesenvolvimento de seus filhos aos 12 meses de idade. Esse manuscrito está formatado de acordo com as normas do periódico ‘Parasitology Research’ e será submetido para publicação após as correções sugeridas pela banca. Por fim, estão as considerações finais e as perspectivas futuras, integrando os resultados desta tese e dos demais fatores determinantes socioambientais que têm efeito adverso no neurodesenvolvimento infantil nesta coorte de nascimento realizada no Recôncavo Baiano, o estudo DSAN-12m.This work is part of a broader study called DSAN-12m (Socioenvironmental Determinants of Children's Neurodevelopment at 12 Months: A Longitudinal Study in the Recôncavo Baiano), which aims to investigate the socioenvironmental determinants of children's neurodevelopment at 12 months of age in a birth cohort in the Recôncavo Baiano region.In this thesis, the current state of the art regarding the relationships between maternal immune activation, chronic/latent prenatal infectious diseases, and neurodevelopment was assessed. Additionally, two original manuscripts were developed to investigate the impact of infections during pregnancy, particularly in the absence of evidence of acute disease, on fetal growth at birth and on children's neurodevelopment at 12 months of age. For better organization, the text was divided into a review manuscript, which presents the theoretical framework and systematizes publications on the thesis topic. Following this, two original manuscripts are presented, followed by final considerations to maintain the coherence of the work. The first manuscript, titled “Impact of Chronic Toxoplasmosis in Pregnancy: Association between Maternal Seropositivity for Toxoplasma gondii IgG Antibodies and Fetal Growth Restriction”, investigated the relationships between the prevalence of specific antibodies in pregnant women and fetal development alterations at birth. Notably, this manuscript was published in the journal Parasitology Research (ISSN: 1432-1955, Impact Factor: 1.8) in December 2023 (APPENDIX E). The second manuscript, titled “Impact of Chronic Toxoplasmosis in Pregnancy: Association between Maternal IgG Antibodies against Toxoplasma gondii and Neurocognitive Development Effects”, explored the association between the prevalence of specific antibodies in pregnant women and neurodevelopmental alterations in their children at 12 months of age. This manuscript is formatted according to the guidelines of Parasitology Research and will be submitted for publication after incorporating the corrections suggested by the evaluation committee. Finally, the thesis concludes with final considerations and future perspectives, integrating the results of this study with other socioenvironmental determinants that adversely affect child neurodevelopment in this birth cohort conducted in the Recôncavo Baiano, the DSAN-12m study.Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)porUniversidade Federal da BahiaPrograma de Pós-Graduação em Farmácia (PPGFAR) UFBABrasilFaculdade de FarmáciaImmunologyNeurodevelopmentNeurodevelopmental disordersPregnant - diseasesTransmissible diseases during pregnancyTransmissible diseases in fetusesMaternal immune activationAutism in childrenSchizophreniaCNPQ::CIENCIAS DA SAUDE::FARMACIAImunologiaNeurodesenvolvimentoTranstornos do neurodesenvolvimentoGrávidas - doençasDoenças transmissíveis na gravidezDoenças transmissíveis em fetosAtivação imunológica maternaAutismo em criançasEsquizofreniaImpacto das infecções maternas crônicas: associações entre a soropositividade materna para anticorpos IgG contra Toxoplasma gondii com restrição no crescimento fetal e efeitos no neurodesenvolvimento infantilImpact of chronic maternal infections: associations between maternal seropositivity for IgG antibodies against Toxoplasma gondii and fetal growth restriction and effects on child neurodevelopmentDoutoradoinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersionMenezes Filho, José Antoniohttps://orcid.org/0000-0002-3191-4484http://lattes.cnpq.br/5251747226701652Menezes Filho, José Antoniohttps://orcid.org/0000-0002-3191-4484http://lattes.cnpq.br/5251747226701652dos Santos, Carina Carvalhohttps://orcid.org/0000-0002-2898-0851http://lattes.cnpq.br/7313535995130086Carvalho, Chrissie Ferreira dehttp://lattes.cnpq.br/7462908507527257Nunes, Geyanna Dolores Lopeshttp://lattes.cnpq.br/5634808265621291Teixeira, Márcia Cristina Aquinohttps://orcid.org/0000-0003-0477-5092http://lattes.cnpq.br/9452875576136451https://orcid.org/0000-0002-0537-1797http://lattes.cnpq.br/6781085146743004Martinez, Victor OteroBLOMSTRÖM, Å. et al. 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Microbial pathogenesis, 104434 . https://doi.org/10.1016/j.micpath.2020.104434.Z Núñez, E., Ayala, T., Cervantes, G., Roldán-Roldán, G., Esquivel, D., Muñiz-Hernández, S., Salazar, A., Armenta, M., Gómez-Manzo, S., González-Conchillos, H., Luna-Nophal, A., Ramírez, A., Pineda, B., Jiménez-Anguiano, A., & Cruz, V. (2022). Pregestational Exposure to T. gondii Produces Maternal Antibodies That Recognize Fetal Brain Mimotopes and Induces Neurochemical and Behavioral Dysfunction in the Offspring. Cells, 11. https://doi.org/10.3390/cells11233819. Oldenburg, K., O'Shea, T., & Fry, R. (2020). Genetic and epigenetic factors and early life inflammation as predictors of neurodevelopmental outcomes.. Seminars in fetal & neonatal medicine, 101115 . https://doi.org/10.1016/j.siny.2020 Ribeiro, A., Mutis, M., & Fernandes, O. (2008). Association of the presence of residual anti-Toxoplasma gondii IgM in pregnant women and their respective family groups in Miracema, Northwest Rio de Janeiro, Brazil.. Memorias do Instituto Oswaldo Cruz, 103 6, 591-4 . https://doi.org/10.1590/S0074-02762008000600013. Spencer-Smith, M., Spittle, A., Lee, K., Doyle, L., & Anderson, P. (2015). Bayley-III Cognitive and Language Scales in Preterm Children. Pediatrics, 135, e1258 - e1265. https://doi.org/10.1542/peds.2014-3039. Villar J, Cheikh Ismail L, Victora CG, Ohuma EO, Bertino E, Altman DG, Lambert A, Papageorghiou AT, Carvalho M, Jaffer YA, Gravett MG, Purwar M, Frederick IO, Noble AJ, Pang R, Barros FC, Chumlea C, Bhutta ZA, Kennedy SH (2014) International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st). International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH- 21st Project. Lancet 384(9946):857-68. https://10.1016/S0140-6736(14)60932-6. 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(2012) Maternal infection and neurodevelopmental disorders in the offspring. American Journal of Immunology 8(1):10-17.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAORIGINALVictor Martinez. Tese doutorado.pdfVictor Martinez. Tese doutorado.pdfVictor Martinez. 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dc.title.pt_BR.fl_str_mv Impacto das infecções maternas crônicas: associações entre a soropositividade materna para anticorpos IgG contra Toxoplasma gondii com restrição no crescimento fetal e efeitos no neurodesenvolvimento infantil
dc.title.alternative.pt_BR.fl_str_mv Impact of chronic maternal infections: associations between maternal seropositivity for IgG antibodies against Toxoplasma gondii and fetal growth restriction and effects on child neurodevelopment
title Impacto das infecções maternas crônicas: associações entre a soropositividade materna para anticorpos IgG contra Toxoplasma gondii com restrição no crescimento fetal e efeitos no neurodesenvolvimento infantil
spellingShingle Impacto das infecções maternas crônicas: associações entre a soropositividade materna para anticorpos IgG contra Toxoplasma gondii com restrição no crescimento fetal e efeitos no neurodesenvolvimento infantil
Martinez, Victor Otero
CNPQ::CIENCIAS DA SAUDE::FARMACIA
Imunologia
Neurodesenvolvimento
Transtornos do neurodesenvolvimento
Grávidas - doenças
Doenças transmissíveis na gravidez
Doenças transmissíveis em fetos
Ativação imunológica materna
Autismo em crianças
Esquizofrenia
Immunology
Neurodevelopment
Neurodevelopmental disorders
Pregnant - diseases
Transmissible diseases during pregnancy
Transmissible diseases in fetuses
Maternal immune activation
Autism in children
Schizophrenia
title_short Impacto das infecções maternas crônicas: associações entre a soropositividade materna para anticorpos IgG contra Toxoplasma gondii com restrição no crescimento fetal e efeitos no neurodesenvolvimento infantil
title_full Impacto das infecções maternas crônicas: associações entre a soropositividade materna para anticorpos IgG contra Toxoplasma gondii com restrição no crescimento fetal e efeitos no neurodesenvolvimento infantil
title_fullStr Impacto das infecções maternas crônicas: associações entre a soropositividade materna para anticorpos IgG contra Toxoplasma gondii com restrição no crescimento fetal e efeitos no neurodesenvolvimento infantil
title_full_unstemmed Impacto das infecções maternas crônicas: associações entre a soropositividade materna para anticorpos IgG contra Toxoplasma gondii com restrição no crescimento fetal e efeitos no neurodesenvolvimento infantil
title_sort Impacto das infecções maternas crônicas: associações entre a soropositividade materna para anticorpos IgG contra Toxoplasma gondii com restrição no crescimento fetal e efeitos no neurodesenvolvimento infantil
author Martinez, Victor Otero
author_facet Martinez, Victor Otero
author_role author
dc.contributor.advisor1.fl_str_mv Menezes Filho, José Antonio
dc.contributor.advisor1ID.fl_str_mv https://orcid.org/0000-0002-3191-4484
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/5251747226701652
dc.contributor.referee1.fl_str_mv Menezes Filho, José Antonio
dc.contributor.referee1ID.fl_str_mv https://orcid.org/0000-0002-3191-4484
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/5251747226701652
dc.contributor.referee2.fl_str_mv dos Santos, Carina Carvalho
dc.contributor.referee2ID.fl_str_mv https://orcid.org/0000-0002-2898-0851
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/7313535995130086
dc.contributor.referee3.fl_str_mv Carvalho, Chrissie Ferreira de
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/7462908507527257
dc.contributor.referee4.fl_str_mv Nunes, Geyanna Dolores Lopes
dc.contributor.referee4Lattes.fl_str_mv http://lattes.cnpq.br/5634808265621291
dc.contributor.referee5.fl_str_mv Teixeira, Márcia Cristina Aquino
dc.contributor.referee5ID.fl_str_mv https://orcid.org/0000-0003-0477-5092
dc.contributor.referee5Lattes.fl_str_mv http://lattes.cnpq.br/9452875576136451
dc.contributor.authorID.fl_str_mv https://orcid.org/0000-0002-0537-1797
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/6781085146743004
dc.contributor.author.fl_str_mv Martinez, Victor Otero
contributor_str_mv Menezes Filho, José Antonio
Menezes Filho, José Antonio
dos Santos, Carina Carvalho
Carvalho, Chrissie Ferreira de
Nunes, Geyanna Dolores Lopes
Teixeira, Márcia Cristina Aquino
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS DA SAUDE::FARMACIA
topic CNPQ::CIENCIAS DA SAUDE::FARMACIA
Imunologia
Neurodesenvolvimento
Transtornos do neurodesenvolvimento
Grávidas - doenças
Doenças transmissíveis na gravidez
Doenças transmissíveis em fetos
Ativação imunológica materna
Autismo em crianças
Esquizofrenia
Immunology
Neurodevelopment
Neurodevelopmental disorders
Pregnant - diseases
Transmissible diseases during pregnancy
Transmissible diseases in fetuses
Maternal immune activation
Autism in children
Schizophrenia
dc.subject.por.fl_str_mv Imunologia
Neurodesenvolvimento
Transtornos do neurodesenvolvimento
Grávidas - doenças
Doenças transmissíveis na gravidez
Doenças transmissíveis em fetos
Ativação imunológica materna
Autismo em crianças
Esquizofrenia
dc.subject.other.pt_BR.fl_str_mv Immunology
Neurodevelopment
Neurodevelopmental disorders
Pregnant - diseases
Transmissible diseases during pregnancy
Transmissible diseases in fetuses
Maternal immune activation
Autism in children
Schizophrenia
description Este trabalho faz parte de um estudo amplo, denominado DSAN-12m (Determinantes socioambientais do neurodesenvolvimento de crianças aos 12 meses: Um estudo longitudinal no Recôncavo Baiano), cujo objetivo é investigar os determinantes socioambientais do neurodesenvolvimento de crianças aos 12 meses de idade em uma coorte de nascimentos no Recôncavo Baiano. Na presente tese foram avaliados o estado da arte atual quanto às relações entre a ativação imunológica materna, doenças infecciosas crônicas/latentes pré-natais e o neurodesenvolvimento. Além disso, foram elaborados dois manuscritos originais, que visaram investigar o impacto de infecções durante o período gestacional, particularmente quando não há evidencias de doença aguda, no crescimento fetal ao nascimento e no neurodesenvolvimento infantil os 12 meses de idade. Para melhor organização, o texto foi dividido em um manuscrito de revisão, que apresenta o referencial teórico e sistematiza as publicações sobre o tema da tese. Em seguida, são apresentados dois manuscritos originais, seguidos por considerações finais, a fim de manter a unidade do trabalho. O primeiro manuscrito, intitulado “Impact of chronic toxoplasmosis in pregnancy: association between maternal seropositivity for Toxoplasma gondii IgG antibodies and fetal growth restriction”, investigou as relações entre a prevalência de anticorpos específicos em gestantes e alterações no desenvolvimento fetal ao nascimento. Destaca-se que este manuscrito foi publicado no periódico ‘Parasitology Research’ (ISSN: 1432-1955, Fator de impacto: 1,8) em dezembro de 2023 (APÊNDICE E). O segundo manuscrito, com o título “Impact of Chronic Toxoplasmosis in Pregnancy: Association between maternal IgG antibodies against Toxoplasma gondii and neurocognitive development effects”, explorou a associação entre a prevalência de anticorpos específicos em gestantes com alterações no neurodesenvolvimento de seus filhos aos 12 meses de idade. Esse manuscrito está formatado de acordo com as normas do periódico ‘Parasitology Research’ e será submetido para publicação após as correções sugeridas pela banca. Por fim, estão as considerações finais e as perspectivas futuras, integrando os resultados desta tese e dos demais fatores determinantes socioambientais que têm efeito adverso no neurodesenvolvimento infantil nesta coorte de nascimento realizada no Recôncavo Baiano, o estudo DSAN-12m.
publishDate 2024
dc.date.issued.fl_str_mv 2024-12-06
dc.date.accessioned.fl_str_mv 2025-03-16T02:08:05Z
dc.date.available.fl_str_mv 2025-03-16T02:08:05Z
dc.type.driver.fl_str_mv Doutorado
info:eu-repo/semantics/doctoralThesis
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv Martinez, Victor Otero. Impacto das infecções maternas crônicas: associações entre a soropositividade materna para anticorpos IgG contra Toxoplasma gondii com restrição no crescimento fetal e efeitos no neuro desenvolvimento infantil / Victor Otero Martinez. - 2024. 114 f.: il.
dc.identifier.uri.fl_str_mv https://repositorio.ufba.br/handle/ri/41452
identifier_str_mv Martinez, Victor Otero. Impacto das infecções maternas crônicas: associações entre a soropositividade materna para anticorpos IgG contra Toxoplasma gondii com restrição no crescimento fetal e efeitos no neuro desenvolvimento infantil / Victor Otero Martinez. - 2024. 114 f.: il.
url https://repositorio.ufba.br/handle/ri/41452
dc.language.iso.fl_str_mv por
language por
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