Parecoxib reduces renal injury in an ischemia/reperfusion model in rats

Bibliographic Details
Main Author: Calistro Neto,José Pedro
Publication Date: 2015
Other Authors: Torres,Rômulo da Costa, Gonçalves,Giovanna Maria, Silva,Leopoldo Muniz da, Domingues,Maria Aparecida Custódio, Módolo,Norma Sueli Pinheiro, Barros,Guilherme Antonio Moreira de
Format: Article
Language: eng
Source: Acta Cirúrgica Brasileira (Online)
Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000400270
Summary: PURPOSE: To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups.RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups.CONCLUSION:Parecoxib resulted in renal protection in this experimental model.
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spelling Parecoxib reduces renal injury in an ischemia/reperfusion model in ratsParecoxibIschemiaReperfusionKidneyRatsPURPOSE: To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups.RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups.CONCLUSION:Parecoxib resulted in renal protection in this experimental model.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2015-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000400270Acta Cirúrgica Brasileira v.30 n.4 2015reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-865020150040000006info:eu-repo/semantics/openAccessCalistro Neto,José PedroTorres,Rômulo da CostaGonçalves,Giovanna MariaSilva,Leopoldo Muniz daDomingues,Maria Aparecida CustódioMódolo,Norma Sueli PinheiroBarros,Guilherme Antonio Moreira deeng2015-10-08T00:00:00Zoai:scielo:S0102-86502015000400270Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2015-10-08T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Parecoxib reduces renal injury in an ischemia/reperfusion model in rats
title Parecoxib reduces renal injury in an ischemia/reperfusion model in rats
spellingShingle Parecoxib reduces renal injury in an ischemia/reperfusion model in rats
Calistro Neto,José Pedro
Parecoxib
Ischemia
Reperfusion
Kidney
Rats
title_short Parecoxib reduces renal injury in an ischemia/reperfusion model in rats
title_full Parecoxib reduces renal injury in an ischemia/reperfusion model in rats
title_fullStr Parecoxib reduces renal injury in an ischemia/reperfusion model in rats
title_full_unstemmed Parecoxib reduces renal injury in an ischemia/reperfusion model in rats
title_sort Parecoxib reduces renal injury in an ischemia/reperfusion model in rats
author Calistro Neto,José Pedro
author_facet Calistro Neto,José Pedro
Torres,Rômulo da Costa
Gonçalves,Giovanna Maria
Silva,Leopoldo Muniz da
Domingues,Maria Aparecida Custódio
Módolo,Norma Sueli Pinheiro
Barros,Guilherme Antonio Moreira de
author_role author
author2 Torres,Rômulo da Costa
Gonçalves,Giovanna Maria
Silva,Leopoldo Muniz da
Domingues,Maria Aparecida Custódio
Módolo,Norma Sueli Pinheiro
Barros,Guilherme Antonio Moreira de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Calistro Neto,José Pedro
Torres,Rômulo da Costa
Gonçalves,Giovanna Maria
Silva,Leopoldo Muniz da
Domingues,Maria Aparecida Custódio
Módolo,Norma Sueli Pinheiro
Barros,Guilherme Antonio Moreira de
dc.subject.por.fl_str_mv Parecoxib
Ischemia
Reperfusion
Kidney
Rats
topic Parecoxib
Ischemia
Reperfusion
Kidney
Rats
description PURPOSE: To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups.RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups.CONCLUSION:Parecoxib resulted in renal protection in this experimental model.
publishDate 2015
dc.date.none.fl_str_mv 2015-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000400270
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000400270
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-865020150040000006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.30 n.4 2015
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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