Linking glycation and glycosylation with inflammation and mitochondrial dysfunction in Parkinson's disease

Bibliographic Details
Main Author: Videira, Paula A. Q.
Publication Date: 2018
Other Authors: Castro-Caldas, Margarida
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://doi.org/10.3389/fnins.2018.00381
Summary: This work was supported by Fundacao para a Ciencia e a Tecnologia (FCT), and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728).
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spelling Linking glycation and glycosylation with inflammation and mitochondrial dysfunction in Parkinson's diseaseAgingGlycationGlycosylationInflammationMitochondrial dysfunctionParkinson's diseaseNeuroscience(all)This work was supported by Fundacao para a Ciencia e a Tecnologia (FCT), and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728).Parkinson's disease (PD) is the second most common neurodegenerative disorder, affecting about 6.3 million people worldwide. PD is characterized by the progressive degeneration of dopaminergic neurons in the Substantia nigra pars compacta, resulting into severe motor symptoms. The cellular mechanisms underlying dopaminergic cell death in PD are still not fully understood, but mitochondrial dysfunction, oxidative stress and inflammation are strongly implicated in the pathogenesis of both familial and sporadic PD cases. Aberrant post-translational modifications, namely glycation and glycosylation, together with age-dependent insufficient endogenous scavengers and quality control systems, lead to cellular overload of dysfunctional proteins. Such injuries accumulate with time and may lead to mitochondrial dysfunction and exacerbated inflammatory responses, culminating in neuronal cell death. Here, we will discuss how PD-linked protein mutations, aging, impaired quality control mechanisms and sugar metabolism lead to up-regulated abnormal post-translational modifications in proteins. Abnormal glycation and glycosylation seem to be more common than previously thought in PD and may underlie mitochondria-induced oxidative stress and inflammation in a feed-forward mechanism. Moreover, the stress-induced post-translational modifications that directly affect parkin and/or its substrates, deeply impairing its ability to regulate mitochondrial dynamics or to suppress inflammation will also be discussed. Together, these represent still unexplored deleterious mechanisms implicated in neurodegeneration in PD, which may be used for a more in-depth knowledge of the pathogenic mechanisms, or as biomarkers of the disease.DCV - Departamento de Ciências da VidaUCIBIO - Applied Molecular Biosciences UnitRUNVideira, Paula A. Q.Castro-Caldas, Margarida2019-02-01T23:44:32Z2018-06-072018-06-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttps://doi.org/10.3389/fnins.2018.00381eng1662-4548PURE: 4440040http://www.scopus.com/inward/record.url?scp=85048250230&partnerID=8YFLogxKhttps://doi.org/10.3389/fnins.2018.00381info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:36:57Zoai:run.unl.pt:10362/59316Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:08:04.359468Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Linking glycation and glycosylation with inflammation and mitochondrial dysfunction in Parkinson's disease
title Linking glycation and glycosylation with inflammation and mitochondrial dysfunction in Parkinson's disease
spellingShingle Linking glycation and glycosylation with inflammation and mitochondrial dysfunction in Parkinson's disease
Videira, Paula A. Q.
Aging
Glycation
Glycosylation
Inflammation
Mitochondrial dysfunction
Parkinson's disease
Neuroscience(all)
title_short Linking glycation and glycosylation with inflammation and mitochondrial dysfunction in Parkinson's disease
title_full Linking glycation and glycosylation with inflammation and mitochondrial dysfunction in Parkinson's disease
title_fullStr Linking glycation and glycosylation with inflammation and mitochondrial dysfunction in Parkinson's disease
title_full_unstemmed Linking glycation and glycosylation with inflammation and mitochondrial dysfunction in Parkinson's disease
title_sort Linking glycation and glycosylation with inflammation and mitochondrial dysfunction in Parkinson's disease
author Videira, Paula A. Q.
author_facet Videira, Paula A. Q.
Castro-Caldas, Margarida
author_role author
author2 Castro-Caldas, Margarida
author2_role author
dc.contributor.none.fl_str_mv DCV - Departamento de Ciências da Vida
UCIBIO - Applied Molecular Biosciences Unit
RUN
dc.contributor.author.fl_str_mv Videira, Paula A. Q.
Castro-Caldas, Margarida
dc.subject.por.fl_str_mv Aging
Glycation
Glycosylation
Inflammation
Mitochondrial dysfunction
Parkinson's disease
Neuroscience(all)
topic Aging
Glycation
Glycosylation
Inflammation
Mitochondrial dysfunction
Parkinson's disease
Neuroscience(all)
description This work was supported by Fundacao para a Ciencia e a Tecnologia (FCT), and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728).
publishDate 2018
dc.date.none.fl_str_mv 2018-06-07
2018-06-07T00:00:00Z
2019-02-01T23:44:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.3389/fnins.2018.00381
url https://doi.org/10.3389/fnins.2018.00381
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1662-4548
PURE: 4440040
http://www.scopus.com/inward/record.url?scp=85048250230&partnerID=8YFLogxK
https://doi.org/10.3389/fnins.2018.00381
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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