Electrochemical behaviour of isatin at a glassy carbon electrode

• Main Author: Diculescu, Victor C.
• Publication Date: 2006
• Other Authors: Kumbhat, Sunita, Brett, Ana Maria Oliveira
• Format: Article
• Language: eng
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: https://hdl.handle.net/10316/5076; https://doi.org/10.1016/j.bioelechem.2006.03.015
• topic: Oxidation; Reduction; Voltammetry

The electrochemical behavior of isatin - a molecule with a broad range of applications in synthetic, biological and clinical activity - has been investigated over a wide pH range at a glassy carbon electrode (GCE) using cyclic, square wave and differential pulse voltammetry. The oxidation of isatin is an irreversible process, pH dependent and occurs with the formation of a main oxidation product that strongly adsorbs on the electrode surface. The reduction of isatin is also a pH dependent irreversible process. Cyclic voltammograms show two consecutive charge transfer reactions. The diffusion coefficient of isatin was calculated in pH 7.0 phosphate buffer to be D0 = 4.9 × 10-7 cm2 s-1. The limit of detection obtained in a solution of pH 7.0 phosphate buffer was LOD = 0.194 [mu]M, based on three times the noise level.