Study of the fosfosal controlled permeation through glutaraldehyde crosslinked chitosan membranes

Bibliographic Details
Main Author: Silva, R. M.
Publication Date: 2006
Other Authors: Mano, J. F., Reis, R. L.
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/1822/14415
Summary: Advanced material forum III: proceedings of the III International Materials Symposium, Aveiro, 2005
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spelling Study of the fosfosal controlled permeation through glutaraldehyde crosslinked chitosan membranesChitosanDrug releaseFosfosalDiffusion cellBiodegradableGlutaraldehydeScience & TechnologyAdvanced material forum III: proceedings of the III International Materials Symposium, Aveiro, 2005Fosfosal, a phosphate derivative of salicylic acid, which presents both analgesic and antiinflammatory properties, was used as a model drug to study the potential of recently developed chitosan membranes (with different crosslinking degrees) to be used as drug release rate-controlling membranes. The fosfosal permeation across these membranes was studied using an in-house built developed diffusion cell with online automatic monitoring. Experiments were performed using phosphate buffer saline (PBS) solution at 37ºC. Different flow properties of the detection set up were determined in order to estimate the errors introduced by the automatic online monitoring system. For increasing crosslinking degrees the permeability initially decreased, and then increased, likely as a consequence of the crosslinking influence on a variety of properties like crystallinity and hydrophilicity that have opposite influence on permeability. In summary, it was possible to control the drug release profile by means of changing the degree of crosslinking of chitosan membranes and to follow the respective release kinetics by means of using the developed diffusion cell(undefined)Trans Tech PublicationsUniversidade do MinhoSilva, R. M.Mano, J. F.Reis, R. L.20062006-01-01T00:00:00Zconference paperinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/1822/14415engSilva, R. M. P. da ., Mano, J. F., & Reis, R. L. (2006, May 15). Study of the Fosfosal Controlled Permeation through Glutaraldehyde Crosslinked Chitosan Membranes. Materials Science Forum. Trans Tech Publications, Ltd. http://doi.org/10.4028/www.scientific.net/msf.514-516.99097808784940261662-975210.4028/www.scientific.net/MSF.514-516.990https://www.scientific.net/MSF.514-516.990info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-09-07T01:31:40Zoai:repositorium.sdum.uminho.pt:1822/14415Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T16:08:04.336483Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Study of the fosfosal controlled permeation through glutaraldehyde crosslinked chitosan membranes
title Study of the fosfosal controlled permeation through glutaraldehyde crosslinked chitosan membranes
spellingShingle Study of the fosfosal controlled permeation through glutaraldehyde crosslinked chitosan membranes
Silva, R. M.
Chitosan
Drug release
Fosfosal
Diffusion cell
Biodegradable
Glutaraldehyde
Science & Technology
title_short Study of the fosfosal controlled permeation through glutaraldehyde crosslinked chitosan membranes
title_full Study of the fosfosal controlled permeation through glutaraldehyde crosslinked chitosan membranes
title_fullStr Study of the fosfosal controlled permeation through glutaraldehyde crosslinked chitosan membranes
title_full_unstemmed Study of the fosfosal controlled permeation through glutaraldehyde crosslinked chitosan membranes
title_sort Study of the fosfosal controlled permeation through glutaraldehyde crosslinked chitosan membranes
author Silva, R. M.
author_facet Silva, R. M.
Mano, J. F.
Reis, R. L.
author_role author
author2 Mano, J. F.
Reis, R. L.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Silva, R. M.
Mano, J. F.
Reis, R. L.
dc.subject.por.fl_str_mv Chitosan
Drug release
Fosfosal
Diffusion cell
Biodegradable
Glutaraldehyde
Science & Technology
topic Chitosan
Drug release
Fosfosal
Diffusion cell
Biodegradable
Glutaraldehyde
Science & Technology
description Advanced material forum III: proceedings of the III International Materials Symposium, Aveiro, 2005
publishDate 2006
dc.date.none.fl_str_mv 2006
2006-01-01T00:00:00Z
dc.type.driver.fl_str_mv conference paper
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/14415
url https://hdl.handle.net/1822/14415
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Silva, R. M. P. da ., Mano, J. F., & Reis, R. L. (2006, May 15). Study of the Fosfosal Controlled Permeation through Glutaraldehyde Crosslinked Chitosan Membranes. Materials Science Forum. Trans Tech Publications, Ltd. http://doi.org/10.4028/www.scientific.net/msf.514-516.990
9780878494026
1662-9752
10.4028/www.scientific.net/MSF.514-516.990
https://www.scientific.net/MSF.514-516.990
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Trans Tech Publications
publisher.none.fl_str_mv Trans Tech Publications
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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