Numerical evaluation and experimental validation of fluid flow behavior within an organ-on-a-chip model

Detalhes bibliográficos
Autor(a) principal: Carvalho, Violeta Meneses
Data de Publicação: 2024
Outros Autores: Gonçalves, Inês M., Rodrigues, Nelson, Sousa, Paulo, Pinto, Vânia, Minas, Graça, Kaji, Hirokazu, Shin, Su Ryon, Rodrigues, Raquel O., Teixeira, Senhorinha F. C. F., Lima, Rui A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: https://hdl.handle.net/1822/87457
Resumo: By combining biomaterials, cell culture, and microfluidic technology, organ-on-a-chip (OoC) platforms have the ability to reproduce the physiological microenvironment of human organs. For this reason, these advanced microfluidic devices have been used to resemble various diseases and investigate novel treatments. In addition to the experimental assessment, numerical studies of biodevices have been performed aiming at their improvement and optimization. Despite considerable progress in numerical modeling of biodevices, the validation of these computational models through comparison with experimental assays remains a significant gap in the current literature. This step is critical to ensure the accuracy and reliability of numerical models, and consequently enhance confidence in their predictive results. The aim of the present work is to develop a numerical model capable of reproducing the fluid flow behavior within an OoC, for future investigations, encompassing the geometry optimization.
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spelling Numerical evaluation and experimental validation of fluid flow behavior within an organ-on-a-chip modelOrgan/on/a/chipCFDComputational simulationsMicrofluidicsBiofluid mechanicsExperimental validartionExperimental validationEngenharia e Tecnologia::Engenharia Eletrotécnica, Eletrónica e InformáticaBy combining biomaterials, cell culture, and microfluidic technology, organ-on-a-chip (OoC) platforms have the ability to reproduce the physiological microenvironment of human organs. For this reason, these advanced microfluidic devices have been used to resemble various diseases and investigate novel treatments. In addition to the experimental assessment, numerical studies of biodevices have been performed aiming at their improvement and optimization. Despite considerable progress in numerical modeling of biodevices, the validation of these computational models through comparison with experimental assays remains a significant gap in the current literature. This step is critical to ensure the accuracy and reliability of numerical models, and consequently enhance confidence in their predictive results. The aim of the present work is to develop a numerical model capable of reproducing the fluid flow behavior within an OoC, for future investigations, encompassing the geometry optimization.This work has been supported by the projects, EXPL/EMD-EMD/0650/2021, PTDC/EEI-EEE/2846/2021, and 2022.06207.PTDC (https://doi.org/10.54499/2022.06207.PTDC), through national funds (OE), within the scope of the Scientific Research and Technological Development Projects (IC&DT) program in all scientific domains (PTDC), through the Foundation for Science and Technology, I.P. (FCT,I.P). The authors also acknowledge the partial financial support withinthe R&D Units Project Scope: UIDB/00319/2020, UIDB/04077/2020, UIDB/04436/2020, UIDB/00532/2020 and LA/P/0045/2020 (ALiCE).Violeta Carvalho thanks for her Ph.D. grant from FCT with reference UI/BD/151028/2021 and Fulbright Grant for Research with the support of FCT, AY2022/2023. Inês M. Gonçalves acknowledges the PhD scholarship BD/08646/2020 attributed by FCT. Paulo Sousa thanks FCT for his contract funding provided through 2021.01086.CEECIND, Vˆania Pinto thanks FCT for her contract funding provided through 2021.01087.CEECIND and Raquel O. Rodrigues thanks FCT for her contract funding provided through 2020.03975.CEECIND. The authors also acknowledge the partial financial support of the project n◦4004 from the RCBE from Tokyo Medical and Dental University, Japan.ElsevierUniversidade do MinhoCarvalho, Violeta MenesesGonçalves, Inês M.Rodrigues, NelsonSousa, PauloPinto, VâniaMinas, GraçaKaji, HirokazuShin, Su RyonRodrigues, Raquel O.Teixeira, Senhorinha F. C. F.Lima, Rui A.20242024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/87457engCarvalho, V., Gonçalves, I. M., Rodrigues, N., Sousa, P., Pinto, V., Minas, G., … Lima, R. A. (2024, January). Numerical evaluation and experimental validation of fluid flow behavior within an organ-on-a-chip model. Computer Methods and Programs in Biomedicine. Elsevier BV. http://doi.org/10.1016/j.cmpb.2023.1078830169-260710.1016/j.cmpb.2023.10788337944399107883https://www.sciencedirect.com/science/article/pii/S0169260723005497info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-04-12T03:52:09Zoai:repositorium.sdum.uminho.pt:1822/87457Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T14:42:15.911045Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Numerical evaluation and experimental validation of fluid flow behavior within an organ-on-a-chip model
title Numerical evaluation and experimental validation of fluid flow behavior within an organ-on-a-chip model
spellingShingle Numerical evaluation and experimental validation of fluid flow behavior within an organ-on-a-chip model
Carvalho, Violeta Meneses
Organ/on/a/chip
CFD
Computational simulations
Microfluidics
Biofluid mechanics
Experimental validartion
Experimental validation
Engenharia e Tecnologia::Engenharia Eletrotécnica, Eletrónica e Informática
title_short Numerical evaluation and experimental validation of fluid flow behavior within an organ-on-a-chip model
title_full Numerical evaluation and experimental validation of fluid flow behavior within an organ-on-a-chip model
title_fullStr Numerical evaluation and experimental validation of fluid flow behavior within an organ-on-a-chip model
title_full_unstemmed Numerical evaluation and experimental validation of fluid flow behavior within an organ-on-a-chip model
title_sort Numerical evaluation and experimental validation of fluid flow behavior within an organ-on-a-chip model
author Carvalho, Violeta Meneses
author_facet Carvalho, Violeta Meneses
Gonçalves, Inês M.
Rodrigues, Nelson
Sousa, Paulo
Pinto, Vânia
Minas, Graça
Kaji, Hirokazu
Shin, Su Ryon
Rodrigues, Raquel O.
Teixeira, Senhorinha F. C. F.
Lima, Rui A.
author_role author
author2 Gonçalves, Inês M.
Rodrigues, Nelson
Sousa, Paulo
Pinto, Vânia
Minas, Graça
Kaji, Hirokazu
Shin, Su Ryon
Rodrigues, Raquel O.
Teixeira, Senhorinha F. C. F.
Lima, Rui A.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Carvalho, Violeta Meneses
Gonçalves, Inês M.
Rodrigues, Nelson
Sousa, Paulo
Pinto, Vânia
Minas, Graça
Kaji, Hirokazu
Shin, Su Ryon
Rodrigues, Raquel O.
Teixeira, Senhorinha F. C. F.
Lima, Rui A.
dc.subject.por.fl_str_mv Organ/on/a/chip
CFD
Computational simulations
Microfluidics
Biofluid mechanics
Experimental validartion
Experimental validation
Engenharia e Tecnologia::Engenharia Eletrotécnica, Eletrónica e Informática
topic Organ/on/a/chip
CFD
Computational simulations
Microfluidics
Biofluid mechanics
Experimental validartion
Experimental validation
Engenharia e Tecnologia::Engenharia Eletrotécnica, Eletrónica e Informática
description By combining biomaterials, cell culture, and microfluidic technology, organ-on-a-chip (OoC) platforms have the ability to reproduce the physiological microenvironment of human organs. For this reason, these advanced microfluidic devices have been used to resemble various diseases and investigate novel treatments. In addition to the experimental assessment, numerical studies of biodevices have been performed aiming at their improvement and optimization. Despite considerable progress in numerical modeling of biodevices, the validation of these computational models through comparison with experimental assays remains a significant gap in the current literature. This step is critical to ensure the accuracy and reliability of numerical models, and consequently enhance confidence in their predictive results. The aim of the present work is to develop a numerical model capable of reproducing the fluid flow behavior within an OoC, for future investigations, encompassing the geometry optimization.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/87457
url https://hdl.handle.net/1822/87457
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Carvalho, V., Gonçalves, I. M., Rodrigues, N., Sousa, P., Pinto, V., Minas, G., … Lima, R. A. (2024, January). Numerical evaluation and experimental validation of fluid flow behavior within an organ-on-a-chip model. Computer Methods and Programs in Biomedicine. Elsevier BV. http://doi.org/10.1016/j.cmpb.2023.107883
0169-2607
10.1016/j.cmpb.2023.107883
37944399
107883
https://www.sciencedirect.com/science/article/pii/S0169260723005497
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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