A randomized controlled trial of a weight loss maintenance program in adults with obesity

Bibliographic Details
Main Author: Pereira, Vanessa
Publication Date: 2024
Other Authors: Barreiros-Mota, Inês, Cortez, Filipa, Castela, Inês, Teixeira, Diana, Calhau, Conceição, Camila Dias, Cláudia, Moreira-Rosário, André, Silvestre, Marta P.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/168911
Summary: Funding Information: This work was sponsored by Farmodietica S.A. The study was also promoted by the CINTESIS@RISE, NOVA Medical School, NOVA University of Lisbon and financed by national funds through FCT Fundacao para a Ciencia e a Technologia, I.P., within the scope of the project \u201CRISE \u2013 LA/P/0053/2020\u201D. The sponsor and funder had no role in the study design and had no role during its execution, analysis, interpretation of the data, or decision to submit the results. Publisher Copyright: © The Author(s), under exclusive licence to Springer Nature Limited 2024.
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spelling A randomized controlled trial of a weight loss maintenance program in adults with obesitythe WLM3P studyLifestyle-based intensive interventionObesityWeight lossWeight maintenanceMedicine (miscellaneous)Nutrition and DieteticsSDG 3 - Good Health and Well-beingFunding Information: This work was sponsored by Farmodietica S.A. The study was also promoted by the CINTESIS@RISE, NOVA Medical School, NOVA University of Lisbon and financed by national funds through FCT Fundacao para a Ciencia e a Technologia, I.P., within the scope of the project \u201CRISE \u2013 LA/P/0053/2020\u201D. The sponsor and funder had no role in the study design and had no role during its execution, analysis, interpretation of the data, or decision to submit the results. Publisher Copyright: © The Author(s), under exclusive licence to Springer Nature Limited 2024.Background/Objectives: The escalating obesity epidemic necessitates effective, sustainable weight loss (WL) and maintenance strategies. This study aimed to evaluate the effectiveness of the Weight Loss Maintenance 3 Phases Program (WLM3P) in achieving a clinically significant long-term weight loss (WL) (≥5% initial WL at 18 months) in adults with obesity compared to a standard low-carbohydrate diet (LCD). Subjects/Methods: In this two-phase trial, 112 participants targeting initial WL (0–6 months) and subsequent maintenance (7–18 months) were randomly assigned to either WLM3P or LCD groups. Outcomes assessed included change in body weight (kg, %), improvements in body composition, and metabolic profile. Results: Of 112 randomized participants, 69% (n = 77) completed the study. At 18 months, WL in the WLM3P group (n = 40) was 15.5 ± 8.3% compared to 9.6 ± 8.5% in the LCD group (n = 37) (p < 0.001). The odds ratio of achieving WL ≥ 10% and ≥15% were significantly higher in the WLM3P group. Complete-case analysis revealed significantly greater improvements in BMI, body fat mass, visceral fat area, waist circumference, waist-to-hip ratio, HDL, and triglyceride/HDL ratio in WLM3P than in LCD. No serious adverse events were reported. Conclusion: Both programs effectively promoted clinically relevant WL and its maintenance. However, the WLM3P program was more successful in helping participants achieve greater WL targets of ≥10% and ≥15%, along with other clinical benefits, after an 18-month intervention. Trial registration number: NCT04192357.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSCentro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS)RUNPereira, VanessaBarreiros-Mota, InêsCortez, FilipaCastela, InêsTeixeira, DianaCalhau, ConceiçãoCamila Dias, CláudiaMoreira-Rosário, AndréSilvestre, Marta P.2024-06-21T22:26:07Z2024-082024-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/168911eng0954-3007PURE: 93698399https://doi.org/10.1038/s41430-024-01454-4info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-26T01:41:17Zoai:run.unl.pt:10362/168911Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:56:26.233106Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv A randomized controlled trial of a weight loss maintenance program in adults with obesity
the WLM3P study
title A randomized controlled trial of a weight loss maintenance program in adults with obesity
spellingShingle A randomized controlled trial of a weight loss maintenance program in adults with obesity
Pereira, Vanessa
Lifestyle-based intensive intervention
Obesity
Weight loss
Weight maintenance
Medicine (miscellaneous)
Nutrition and Dietetics
SDG 3 - Good Health and Well-being
title_short A randomized controlled trial of a weight loss maintenance program in adults with obesity
title_full A randomized controlled trial of a weight loss maintenance program in adults with obesity
title_fullStr A randomized controlled trial of a weight loss maintenance program in adults with obesity
title_full_unstemmed A randomized controlled trial of a weight loss maintenance program in adults with obesity
title_sort A randomized controlled trial of a weight loss maintenance program in adults with obesity
author Pereira, Vanessa
author_facet Pereira, Vanessa
Barreiros-Mota, Inês
Cortez, Filipa
Castela, Inês
Teixeira, Diana
Calhau, Conceição
Camila Dias, Cláudia
Moreira-Rosário, André
Silvestre, Marta P.
author_role author
author2 Barreiros-Mota, Inês
Cortez, Filipa
Castela, Inês
Teixeira, Diana
Calhau, Conceição
Camila Dias, Cláudia
Moreira-Rosário, André
Silvestre, Marta P.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS)
RUN
dc.contributor.author.fl_str_mv Pereira, Vanessa
Barreiros-Mota, Inês
Cortez, Filipa
Castela, Inês
Teixeira, Diana
Calhau, Conceição
Camila Dias, Cláudia
Moreira-Rosário, André
Silvestre, Marta P.
dc.subject.por.fl_str_mv Lifestyle-based intensive intervention
Obesity
Weight loss
Weight maintenance
Medicine (miscellaneous)
Nutrition and Dietetics
SDG 3 - Good Health and Well-being
topic Lifestyle-based intensive intervention
Obesity
Weight loss
Weight maintenance
Medicine (miscellaneous)
Nutrition and Dietetics
SDG 3 - Good Health and Well-being
description Funding Information: This work was sponsored by Farmodietica S.A. The study was also promoted by the CINTESIS@RISE, NOVA Medical School, NOVA University of Lisbon and financed by national funds through FCT Fundacao para a Ciencia e a Technologia, I.P., within the scope of the project \u201CRISE \u2013 LA/P/0053/2020\u201D. The sponsor and funder had no role in the study design and had no role during its execution, analysis, interpretation of the data, or decision to submit the results. Publisher Copyright: © The Author(s), under exclusive licence to Springer Nature Limited 2024.
publishDate 2024
dc.date.none.fl_str_mv 2024-06-21T22:26:07Z
2024-08
2024-08-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/168911
url http://hdl.handle.net/10362/168911
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0954-3007
PURE: 93698399
https://doi.org/10.1038/s41430-024-01454-4
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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