Metabolic dysfunction and peroxisome proliferator-activated receptors (PPAR) in Multiple Sclerosis

Detalhes bibliográficos
Autor(a) principal: Ferret-Sena, Véronique
Data de Publicação: 2018
Outros Autores: Capela, Carlos, Sena, Armando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10400.26/30165
Resumo: "Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS) probably caused, in most cases, by the interaction of genetic and environmental factors. This review first summarizes some clinical, epidemiological and pathological characteristics of MS. Then, the involvement of biochemical pathways is discussed in the development and repair of the CNS lesions and the immune dysfunction in the disease. Finally, the potential roles of peroxisome proliferator-activated receptors (PPAR) in MS are discussed. It is suggested that metabolic mechanisms modulated by PPAR provide a window to integrate the systemic and neurological events underlying the pathogenesis of the disease. In conclusion, the reviewed data highlight molecular avenues of understanding MS that may open new targets for improved therapies and preventive strategies for the disease."
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spelling Metabolic dysfunction and peroxisome proliferator-activated receptors (PPAR) in Multiple SclerosisImmune systemMetabolismMultiple sclerosisNeurodegenerationNeuroinflammationPeroxisome proliferator-activated receptors"Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS) probably caused, in most cases, by the interaction of genetic and environmental factors. This review first summarizes some clinical, epidemiological and pathological characteristics of MS. Then, the involvement of biochemical pathways is discussed in the development and repair of the CNS lesions and the immune dysfunction in the disease. Finally, the potential roles of peroxisome proliferator-activated receptors (PPAR) in MS are discussed. It is suggested that metabolic mechanisms modulated by PPAR provide a window to integrate the systemic and neurological events underlying the pathogenesis of the disease. In conclusion, the reviewed data highlight molecular avenues of understanding MS that may open new targets for improved therapies and preventive strategies for the disease."MDPIRepositório ComumFerret-Sena, VéroniqueCapela, CarlosSena, Armando2019-11-15T16:49:00Z2018-062018-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/30165eng1661-65961422-006710.3390/ijms19061639info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-04-01T17:03:36Zoai:comum.rcaap.pt:10400.26/30165Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T04:47:27.816981Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Metabolic dysfunction and peroxisome proliferator-activated receptors (PPAR) in Multiple Sclerosis
title Metabolic dysfunction and peroxisome proliferator-activated receptors (PPAR) in Multiple Sclerosis
spellingShingle Metabolic dysfunction and peroxisome proliferator-activated receptors (PPAR) in Multiple Sclerosis
Ferret-Sena, Véronique
Immune system
Metabolism
Multiple sclerosis
Neurodegeneration
Neuroinflammation
Peroxisome proliferator-activated receptors
title_short Metabolic dysfunction and peroxisome proliferator-activated receptors (PPAR) in Multiple Sclerosis
title_full Metabolic dysfunction and peroxisome proliferator-activated receptors (PPAR) in Multiple Sclerosis
title_fullStr Metabolic dysfunction and peroxisome proliferator-activated receptors (PPAR) in Multiple Sclerosis
title_full_unstemmed Metabolic dysfunction and peroxisome proliferator-activated receptors (PPAR) in Multiple Sclerosis
title_sort Metabolic dysfunction and peroxisome proliferator-activated receptors (PPAR) in Multiple Sclerosis
author Ferret-Sena, Véronique
author_facet Ferret-Sena, Véronique
Capela, Carlos
Sena, Armando
author_role author
author2 Capela, Carlos
Sena, Armando
author2_role author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Ferret-Sena, Véronique
Capela, Carlos
Sena, Armando
dc.subject.por.fl_str_mv Immune system
Metabolism
Multiple sclerosis
Neurodegeneration
Neuroinflammation
Peroxisome proliferator-activated receptors
topic Immune system
Metabolism
Multiple sclerosis
Neurodegeneration
Neuroinflammation
Peroxisome proliferator-activated receptors
description "Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS) probably caused, in most cases, by the interaction of genetic and environmental factors. This review first summarizes some clinical, epidemiological and pathological characteristics of MS. Then, the involvement of biochemical pathways is discussed in the development and repair of the CNS lesions and the immune dysfunction in the disease. Finally, the potential roles of peroxisome proliferator-activated receptors (PPAR) in MS are discussed. It is suggested that metabolic mechanisms modulated by PPAR provide a window to integrate the systemic and neurological events underlying the pathogenesis of the disease. In conclusion, the reviewed data highlight molecular avenues of understanding MS that may open new targets for improved therapies and preventive strategies for the disease."
publishDate 2018
dc.date.none.fl_str_mv 2018-06
2018-06-01T00:00:00Z
2019-11-15T16:49:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/30165
url http://hdl.handle.net/10400.26/30165
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1661-6596
1422-0067
10.3390/ijms19061639
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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