Shifting gear in antimicrobial and anticancer peptides biophysical studies : from vesicles to cells

Bibliographic Details
Main Author: Freire, João M.
Publication Date: 2015
Other Authors: Gaspar, Diana, Veiga, Ana Salomé, Castanho, Miguel A. R. B.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/23445
Summary: © 2015 European Peptide Society and John Wiley & Sons, Ltd.
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spelling Shifting gear in antimicrobial and anticancer peptides biophysical studies : from vesicles to cellsCellVesiclePeptideMembraneBiophysicsSpectroscopyBacteriaAntimicrobialAnticancerLipid© 2015 European Peptide Society and John Wiley & Sons, Ltd.Despite the intensive study on the mechanism of action of membrane-activemolecules such as antimicrobial and anticancer peptides, most of the biophysical work has been performed using artificial model systems, mainly lipid vesicles. The use of these systems allows full control of the experimental parameters, and to obtain molecular-level detail on the action of peptides, the correlation with biological action is intangible. Recently, several biophysicalmethodologies have been translated to studies using bacterial and cancer cells. Here, we review biophysical studies on the mechanism of action of antimicrobial and anticancer peptides performed directly on cells. The data in these studies allow to correlate vesicle-based and cell-based studies and fill the vesicle-cell interdisciplinary gap.Projects Ciência Sem Fronteiras PVE 171/2012 (CAPES, Brazil) and MSCA-RISE-2014-Nr644167 are acknowledged. D. Gaspar and J. Freire are recipients of fellowships SFRH/BPD/73500/2010 and SFRH/BD/70423/2010 from FCT, Portugal, respectively. A.S. Veiga acknowledges FCT, Portugal, for funding within the FCT Investigator Programme (IF/00803/2012).WileyRepositório da Universidade de LisboaFreire, João M.Gaspar, DianaVeiga, Ana SaloméCastanho, Miguel A. R. B.2016-04-19T13:23:36Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10451/23445engJ. Pept. Sci. 2015; 21: 178–1851075-261710.1002/psc.2741info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T13:28:24Zoai:repositorio.ulisboa.pt:10451/23445Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T02:45:20.516146Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Shifting gear in antimicrobial and anticancer peptides biophysical studies : from vesicles to cells
title Shifting gear in antimicrobial and anticancer peptides biophysical studies : from vesicles to cells
spellingShingle Shifting gear in antimicrobial and anticancer peptides biophysical studies : from vesicles to cells
Freire, João M.
Cell
Vesicle
Peptide
Membrane
Biophysics
Spectroscopy
Bacteria
Antimicrobial
Anticancer
Lipid
title_short Shifting gear in antimicrobial and anticancer peptides biophysical studies : from vesicles to cells
title_full Shifting gear in antimicrobial and anticancer peptides biophysical studies : from vesicles to cells
title_fullStr Shifting gear in antimicrobial and anticancer peptides biophysical studies : from vesicles to cells
title_full_unstemmed Shifting gear in antimicrobial and anticancer peptides biophysical studies : from vesicles to cells
title_sort Shifting gear in antimicrobial and anticancer peptides biophysical studies : from vesicles to cells
author Freire, João M.
author_facet Freire, João M.
Gaspar, Diana
Veiga, Ana Salomé
Castanho, Miguel A. R. B.
author_role author
author2 Gaspar, Diana
Veiga, Ana Salomé
Castanho, Miguel A. R. B.
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Freire, João M.
Gaspar, Diana
Veiga, Ana Salomé
Castanho, Miguel A. R. B.
dc.subject.por.fl_str_mv Cell
Vesicle
Peptide
Membrane
Biophysics
Spectroscopy
Bacteria
Antimicrobial
Anticancer
Lipid
topic Cell
Vesicle
Peptide
Membrane
Biophysics
Spectroscopy
Bacteria
Antimicrobial
Anticancer
Lipid
description © 2015 European Peptide Society and John Wiley & Sons, Ltd.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2016-04-19T13:23:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/23445
url http://hdl.handle.net/10451/23445
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J. Pept. Sci. 2015; 21: 178–185
1075-2617
10.1002/psc.2741
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833601469394190336

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