After a Century of Research into Environmental Mutagens and Carcinogens, Where Do We Stand?

Detalhes bibliográficos
Autor(a) principal: Vitorino, João D.
Data de Publicação: 2023
Outros Autores: Costa, Pedro M.
Tipo de documento: Outros
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10362/158049
Resumo: Publisher Copyright: © 2023 by the authors.
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spelling After a Century of Research into Environmental Mutagens and Carcinogens, Where Do We Stand?biomedicinecancercontaminationgenotoxicantsneoplasiaoccupational exposurepollutionrisk assessmentPollutionPublic Health, Environmental and Occupational HealthHealth, Toxicology and MutagenesisSDG 3 - Good Health and Well-beingPublisher Copyright: © 2023 by the authors.Cancer is one of the longest-known human diseases, yet only in recent times have we begun to perceive that the percentage of neoplasms caused by environmental factors, lifestyle and chemicals, is likely underestimated. The first medical reports associating cancer with pollutants like tars appeared by the early 20th century, but despite initial evidence relating oncogenesis and chromosomal alterations, only after the structure of DNA had been elucidated in the 1950s have genetic disorders been fully perceived as cause. This led to a growing interest in genotoxic and mutagenic pollutants. Even though we are now familiar with a range of environmental carcinogens spanning between aromatic hydrocarbons and asbestos to radionuclides and forms of carbon nanomaterials, establishing causal networks between pollutants and cancer remains cumbersome. In most part, this is due to the complexity of toxicant matrices, unknown modes-of-action of chemicals or their mixtures, the widening array of novel pollutants plus difficulties in subtracting background effects from true aetiology of disease.DCV - Departamento de Ciências da VidaRUNVitorino, João D.Costa, Pedro M.2023-09-20T22:17:51Z2023-01-062023-01-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/other14application/pdfhttp://hdl.handle.net/10362/158049eng1661-7827PURE: 72003062https://doi.org/10.3390/ijerph20021040info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:14:30Zoai:run.unl.pt:10362/158049Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:45:05.398038Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv After a Century of Research into Environmental Mutagens and Carcinogens, Where Do We Stand?
title After a Century of Research into Environmental Mutagens and Carcinogens, Where Do We Stand?
spellingShingle After a Century of Research into Environmental Mutagens and Carcinogens, Where Do We Stand?
Vitorino, João D.
biomedicine
cancer
contamination
genotoxicants
neoplasia
occupational exposure
pollution
risk assessment
Pollution
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis
SDG 3 - Good Health and Well-being
title_short After a Century of Research into Environmental Mutagens and Carcinogens, Where Do We Stand?
title_full After a Century of Research into Environmental Mutagens and Carcinogens, Where Do We Stand?
title_fullStr After a Century of Research into Environmental Mutagens and Carcinogens, Where Do We Stand?
title_full_unstemmed After a Century of Research into Environmental Mutagens and Carcinogens, Where Do We Stand?
title_sort After a Century of Research into Environmental Mutagens and Carcinogens, Where Do We Stand?
author Vitorino, João D.
author_facet Vitorino, João D.
Costa, Pedro M.
author_role author
author2 Costa, Pedro M.
author2_role author
dc.contributor.none.fl_str_mv DCV - Departamento de Ciências da Vida
RUN
dc.contributor.author.fl_str_mv Vitorino, João D.
Costa, Pedro M.
dc.subject.por.fl_str_mv biomedicine
cancer
contamination
genotoxicants
neoplasia
occupational exposure
pollution
risk assessment
Pollution
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis
SDG 3 - Good Health and Well-being
topic biomedicine
cancer
contamination
genotoxicants
neoplasia
occupational exposure
pollution
risk assessment
Pollution
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis
SDG 3 - Good Health and Well-being
description Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-20T22:17:51Z
2023-01-06
2023-01-06T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/158049
url http://hdl.handle.net/10362/158049
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1661-7827
PURE: 72003062
https://doi.org/10.3390/ijerph20021040
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14
application/pdf
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instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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