CD147 and MCT1 - potential partners in bladder cancer aggressiveness and cisplatin resistance

Bibliographic Details
Main Author: Afonso, Julieta Alexandra Pereira
Publication Date: 2015
Other Authors: Santos, Lúcio, Gonçalves, Vera M., Morais, António, Amaro, T., Longatto Filho, Adhemar, Baltazar, Fátima
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/1822/33475
Summary: "Article first published online: 27 SEP 2014"
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spelling CD147 and MCT1 - potential partners in bladder cancer aggressiveness and cisplatin resistanceCD147ChemoresistanceMonocarboxylate transportersTumor microenvironmentUrothelial bladder cancerScience & Technology"Article first published online: 27 SEP 2014"The relapsing and progressive nature of bladder tumors, and the heterogeneity in the response to cisplatin-containing regimens, are the major concerns in the care of urothelial bladder carcinoma (UBC) patients. The metabolic adaptations that alter the tumor microenvironment and thus contribute to chemoresistance have been poorly explored in UBC setting. We found significant associations between the immunoexpressions of the microenvironment-related molecules CD147, monocarboxylate transporters (MCTs) 1 and 4, CD44 and CAIX in tumor tissue sections from 114 UBC patients. The presence of MCT1 and/or MCT4 expressions was significantly associated with unfavorable clinicopathological parameters. The incidence of CD147 positive staining significantly increased with advancing stage, grade and type of lesion, and occurrence of lymphovascular invasion. Similar associations were observed when considering the concurrent expression of CD147 and MCT1. This expression profile lowered significantly the 5-year disease-free and overall survival rates. Moreover, when selecting patients who received platinum-based chemotherapy, the prognosis was significantly worse for those with MCT1 and CD147 positive tumors. CD147 specific silencing by small interfering RNAs (siRNAs) in UBC cells was accompanied by a decrease in MCT1 and MCT4 expressions and, importantly, an increase in chemosensitivity to cisplatin. Our results provide novel insights for the involvement of CD147 and MCTs in bladder cancer progression and resistance to cisplatin-based chemotherapy. We consider that the possible cooperative role of CD147 and MCT1 in determining cisplatin resistance should be further explored as a potential theranostics biomarker.Grant sponsor: Life and Health Sciences Research Institute (ICVS); Grant sponsor: Portuguese Science and Technology Foundation (FCT); Grant number: SFRH/BD/51997/2012WileyUniversidade do MinhoAfonso, Julieta Alexandra PereiraSantos, LúcioGonçalves, Vera M.Morais, AntónioAmaro, T.Longatto Filho, AdhemarBaltazar, Fátima20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/33475engAfonso, J., Santos, L. L., Miranda-Gonçalves, V., Morais, A., Amaro, T., Longatto-Filho, A., & Baltazar, F. (2015). CD147 and MCT1-potential partners in bladder cancer aggressiveness and cisplatin resistance. Molecular Carcinogenesis, 54(11), 1451-1466. doi: 10.1002/mc.222220899-198710.1002/mc.2222225263481http://onlinelibrary.wiley.com/doi/10.1002/mc.22222/abstractinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T06:16:44Zoai:repositorium.sdum.uminho.pt:1822/33475Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T15:47:27.399656Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv CD147 and MCT1 - potential partners in bladder cancer aggressiveness and cisplatin resistance
title CD147 and MCT1 - potential partners in bladder cancer aggressiveness and cisplatin resistance
spellingShingle CD147 and MCT1 - potential partners in bladder cancer aggressiveness and cisplatin resistance
Afonso, Julieta Alexandra Pereira
CD147
Chemoresistance
Monocarboxylate transporters
Tumor microenvironment
Urothelial bladder cancer
Science & Technology
title_short CD147 and MCT1 - potential partners in bladder cancer aggressiveness and cisplatin resistance
title_full CD147 and MCT1 - potential partners in bladder cancer aggressiveness and cisplatin resistance
title_fullStr CD147 and MCT1 - potential partners in bladder cancer aggressiveness and cisplatin resistance
title_full_unstemmed CD147 and MCT1 - potential partners in bladder cancer aggressiveness and cisplatin resistance
title_sort CD147 and MCT1 - potential partners in bladder cancer aggressiveness and cisplatin resistance
author Afonso, Julieta Alexandra Pereira
author_facet Afonso, Julieta Alexandra Pereira
Santos, Lúcio
Gonçalves, Vera M.
Morais, António
Amaro, T.
Longatto Filho, Adhemar
Baltazar, Fátima
author_role author
author2 Santos, Lúcio
Gonçalves, Vera M.
Morais, António
Amaro, T.
Longatto Filho, Adhemar
Baltazar, Fátima
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Afonso, Julieta Alexandra Pereira
Santos, Lúcio
Gonçalves, Vera M.
Morais, António
Amaro, T.
Longatto Filho, Adhemar
Baltazar, Fátima
dc.subject.por.fl_str_mv CD147
Chemoresistance
Monocarboxylate transporters
Tumor microenvironment
Urothelial bladder cancer
Science & Technology
topic CD147
Chemoresistance
Monocarboxylate transporters
Tumor microenvironment
Urothelial bladder cancer
Science & Technology
description "Article first published online: 27 SEP 2014"
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/33475
url http://hdl.handle.net/1822/33475
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Afonso, J., Santos, L. L., Miranda-Gonçalves, V., Morais, A., Amaro, T., Longatto-Filho, A., & Baltazar, F. (2015). CD147 and MCT1-potential partners in bladder cancer aggressiveness and cisplatin resistance. Molecular Carcinogenesis, 54(11), 1451-1466. doi: 10.1002/mc.22222
0899-1987
10.1002/mc.22222
25263481
http://onlinelibrary.wiley.com/doi/10.1002/mc.22222/abstract
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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