Adaptive mutations in bacteria: high rate and small effects

Bibliographic Details
Main Author: Perfeito, Lília
Publication Date: 2007
Other Authors: Fernandes, Lisete, Mota, Catarina, Gordo, Isabel
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.21/3037
Summary: Evolution by natural selection is driven by the continuous generation of adaptive mutations. We measured the genomic mutation rate that generates beneficial mutations and their effects on fitness in Escherichia coli under conditions in which the effect of competition between lineages carrying different beneficial mutations is minimized. We found a rate on the order of 10–5 per genome per generation, which is 1000 times as high as previous estimates, and a mean selective advantage of 1%. Such a high rate of adaptive evolution has implications for the evolution of antibiotic resistance and pathogenicity.
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spelling Adaptive mutations in bacteria: high rate and small effectsAdaptation, BiologicalBiological evolutionEscherichia coli/geneticsEscherichia coli/physiologyGenome, BacterialMicrosatellite repeatsMutationSelection, GeneticEvolution by natural selection is driven by the continuous generation of adaptive mutations. We measured the genomic mutation rate that generates beneficial mutations and their effects on fitness in Escherichia coli under conditions in which the effect of competition between lineages carrying different beneficial mutations is minimized. We found a rate on the order of 10–5 per genome per generation, which is 1000 times as high as previous estimates, and a mean selective advantage of 1%. Such a high rate of adaptive evolution has implications for the evolution of antibiotic resistance and pathogenicity.ScienceRCIPLPerfeito, LíliaFernandes, LiseteMota, CatarinaGordo, Isabel2013-12-31T18:51:21Z2007-082007-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/3037eng1095-9203info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-12T10:30:28Zoai:repositorio.ipl.pt:10400.21/3037Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T20:06:45.150804Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Adaptive mutations in bacteria: high rate and small effects
title Adaptive mutations in bacteria: high rate and small effects
spellingShingle Adaptive mutations in bacteria: high rate and small effects
Perfeito, Lília
Adaptation, Biological
Biological evolution
Escherichia coli/genetics
Escherichia coli/physiology
Genome, Bacterial
Microsatellite repeats
Mutation
Selection, Genetic
title_short Adaptive mutations in bacteria: high rate and small effects
title_full Adaptive mutations in bacteria: high rate and small effects
title_fullStr Adaptive mutations in bacteria: high rate and small effects
title_full_unstemmed Adaptive mutations in bacteria: high rate and small effects
title_sort Adaptive mutations in bacteria: high rate and small effects
author Perfeito, Lília
author_facet Perfeito, Lília
Fernandes, Lisete
Mota, Catarina
Gordo, Isabel
author_role author
author2 Fernandes, Lisete
Mota, Catarina
Gordo, Isabel
author2_role author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Perfeito, Lília
Fernandes, Lisete
Mota, Catarina
Gordo, Isabel
dc.subject.por.fl_str_mv Adaptation, Biological
Biological evolution
Escherichia coli/genetics
Escherichia coli/physiology
Genome, Bacterial
Microsatellite repeats
Mutation
Selection, Genetic
topic Adaptation, Biological
Biological evolution
Escherichia coli/genetics
Escherichia coli/physiology
Genome, Bacterial
Microsatellite repeats
Mutation
Selection, Genetic
description Evolution by natural selection is driven by the continuous generation of adaptive mutations. We measured the genomic mutation rate that generates beneficial mutations and their effects on fitness in Escherichia coli under conditions in which the effect of competition between lineages carrying different beneficial mutations is minimized. We found a rate on the order of 10–5 per genome per generation, which is 1000 times as high as previous estimates, and a mean selective advantage of 1%. Such a high rate of adaptive evolution has implications for the evolution of antibiotic resistance and pathogenicity.
publishDate 2007
dc.date.none.fl_str_mv 2007-08
2007-08-01T00:00:00Z
2013-12-31T18:51:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/3037
url http://hdl.handle.net/10400.21/3037
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1095-9203
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Science
publisher.none.fl_str_mv Science
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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