Effectiveness of Monovalent Rotavirus Vaccine in Mozambique, a Country with a High Burden of Chronic Malnutrition
| Main Author: | |
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| Publication Date: | 2022 |
| Other Authors: | , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/147819 |
Summary: | Funding Information: Funding: This research was funded by GAVI through the Centers for Disease Control and Prevention (CDC), Atlanta and World Health Organization, Regional Office for Africa (WHO/AFRO). African Research in Neglected Tropical Diseases (EFINTD, grant number 89539); Deutsche Forschungsge-meinschaft (DFG; grant number JO369/5-1); Fundo Nacional de Investigação (FNI); United States Agency for International Development (USAID; grant number AID-656-F-16-00002); the Calouste Gulbenkian Foundation from where A.C., F.M., and J.S. have a PhD fellowship. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. |
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Effectiveness of Monovalent Rotavirus Vaccine in Mozambique, a Country with a High Burden of Chronic MalnutritionchildrengastroenteritismalnutritionMozambiquerotavirusvaccine effectivenessRM Therapeutics. PharmacologyRA0421 Public health. Hygiene. Preventive MedicineImmunologyPharmacologyDrug DiscoveryInfectious DiseasesPharmacology (medical)SDG 3 - Good Health and Well-beingSDG 2 - Zero HungerSDG 1 - No PovertyFunding Information: Funding: This research was funded by GAVI through the Centers for Disease Control and Prevention (CDC), Atlanta and World Health Organization, Regional Office for Africa (WHO/AFRO). African Research in Neglected Tropical Diseases (EFINTD, grant number 89539); Deutsche Forschungsge-meinschaft (DFG; grant number JO369/5-1); Fundo Nacional de Investigação (FNI); United States Agency for International Development (USAID; grant number AID-656-F-16-00002); the Calouste Gulbenkian Foundation from where A.C., F.M., and J.S. have a PhD fellowship. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Mozambique introduced monovalent rotavirus vaccine (Rotarix® ) in September 2015. We evaluated the effectiveness of Rotarix® under conditions of routine use in Mozambican children hospitalized with acute gastroenteritis (AGE). A test negative case-control analysis was performed on data collected during 2017–2019 from children <5 years old, admitted with AGE in seven sentinel hospital sites in Mozambique. Adjusted VE was calculated for ≥1 dose of vaccine vs. zero doses using unconditional logistic regression, where VE = (1 − aOR) × 100%. VE estimates were stratified by age group, AGE severity, malnutrition, and genotype. Among 689 children eligible for analysis, 23.7% were rotavirus positive (cases) and 76.3% were negative (controls). The adjusted VE of ≥1 dose in children aged 6–11 months was 52.0% (95% CI, −11, 79), and −24.0% (95% CI, −459, 62) among children aged 12–23 months. Estimated VE was lower in stunted than non-stunted children (14% (95% CI, −138, 66) vs. 59% (95% CI, −125, 91)). Rotavirus vaccination appeared moderately effective against rotavirus gastroenteritis hospitalization in young Mozambican children. VE point estimates were lower in older and stunted children, although confidence intervals were wide and overlapped across strata. These findings provide additional evidence for other high-mortality countries considering rotavirus vaccine introduction.Instituto de Higiene e Medicina Tropical (IHMT)Population health, policies and services (PPS)Global Health and Tropical Medicine (GHTM)RUNChissaque, AssucênioBurke, Rachel M.Guimarães, Esperança L.Manjate, FilomenaNhacolo, ArsénioChilaúle, JorféliaMunlela, BenildeChirinda, PercinaLanga, Jerónimo S.Cossa-Moiane, IdaléciaAnapakala, EldaBauhofer, Adilson Fernando LoforteGarrine, MarcelinoJoão, Eva D.Sambo, JúliaGonçalves, LuziaWeldegebriel, GoitomShaba, KeithBello, Isah MohammedMwenda, Jason M.Parashar, Umesh D.Tate, Jacqueline E.Mandomando, Ináciode Deus, Nilsa2023-01-18T22:17:45Z2022-032022-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/147819engPURE: 50917620https://doi.org/10.3390/vaccines10030449info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:08:19Zoai:run.unl.pt:10362/147819Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:38:45.715482Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Effectiveness of Monovalent Rotavirus Vaccine in Mozambique, a Country with a High Burden of Chronic Malnutrition |
| title |
Effectiveness of Monovalent Rotavirus Vaccine in Mozambique, a Country with a High Burden of Chronic Malnutrition |
| spellingShingle |
Effectiveness of Monovalent Rotavirus Vaccine in Mozambique, a Country with a High Burden of Chronic Malnutrition Chissaque, Assucênio children gastroenteritis malnutrition Mozambique rotavirus vaccine effectiveness RM Therapeutics. Pharmacology RA0421 Public health. Hygiene. Preventive Medicine Immunology Pharmacology Drug Discovery Infectious Diseases Pharmacology (medical) SDG 3 - Good Health and Well-being SDG 2 - Zero Hunger SDG 1 - No Poverty |
| title_short |
Effectiveness of Monovalent Rotavirus Vaccine in Mozambique, a Country with a High Burden of Chronic Malnutrition |
| title_full |
Effectiveness of Monovalent Rotavirus Vaccine in Mozambique, a Country with a High Burden of Chronic Malnutrition |
| title_fullStr |
Effectiveness of Monovalent Rotavirus Vaccine in Mozambique, a Country with a High Burden of Chronic Malnutrition |
| title_full_unstemmed |
Effectiveness of Monovalent Rotavirus Vaccine in Mozambique, a Country with a High Burden of Chronic Malnutrition |
| title_sort |
Effectiveness of Monovalent Rotavirus Vaccine in Mozambique, a Country with a High Burden of Chronic Malnutrition |
| author |
Chissaque, Assucênio |
| author_facet |
Chissaque, Assucênio Burke, Rachel M. Guimarães, Esperança L. Manjate, Filomena Nhacolo, Arsénio Chilaúle, Jorfélia Munlela, Benilde Chirinda, Percina Langa, Jerónimo S. Cossa-Moiane, Idalécia Anapakala, Elda Bauhofer, Adilson Fernando Loforte Garrine, Marcelino João, Eva D. Sambo, Júlia Gonçalves, Luzia Weldegebriel, Goitom Shaba, Keith Bello, Isah Mohammed Mwenda, Jason M. Parashar, Umesh D. Tate, Jacqueline E. Mandomando, Inácio de Deus, Nilsa |
| author_role |
author |
| author2 |
Burke, Rachel M. Guimarães, Esperança L. Manjate, Filomena Nhacolo, Arsénio Chilaúle, Jorfélia Munlela, Benilde Chirinda, Percina Langa, Jerónimo S. Cossa-Moiane, Idalécia Anapakala, Elda Bauhofer, Adilson Fernando Loforte Garrine, Marcelino João, Eva D. Sambo, Júlia Gonçalves, Luzia Weldegebriel, Goitom Shaba, Keith Bello, Isah Mohammed Mwenda, Jason M. Parashar, Umesh D. Tate, Jacqueline E. Mandomando, Inácio de Deus, Nilsa |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Population health, policies and services (PPS) Global Health and Tropical Medicine (GHTM) RUN |
| dc.contributor.author.fl_str_mv |
Chissaque, Assucênio Burke, Rachel M. Guimarães, Esperança L. Manjate, Filomena Nhacolo, Arsénio Chilaúle, Jorfélia Munlela, Benilde Chirinda, Percina Langa, Jerónimo S. Cossa-Moiane, Idalécia Anapakala, Elda Bauhofer, Adilson Fernando Loforte Garrine, Marcelino João, Eva D. Sambo, Júlia Gonçalves, Luzia Weldegebriel, Goitom Shaba, Keith Bello, Isah Mohammed Mwenda, Jason M. Parashar, Umesh D. Tate, Jacqueline E. Mandomando, Inácio de Deus, Nilsa |
| dc.subject.por.fl_str_mv |
children gastroenteritis malnutrition Mozambique rotavirus vaccine effectiveness RM Therapeutics. Pharmacology RA0421 Public health. Hygiene. Preventive Medicine Immunology Pharmacology Drug Discovery Infectious Diseases Pharmacology (medical) SDG 3 - Good Health and Well-being SDG 2 - Zero Hunger SDG 1 - No Poverty |
| topic |
children gastroenteritis malnutrition Mozambique rotavirus vaccine effectiveness RM Therapeutics. Pharmacology RA0421 Public health. Hygiene. Preventive Medicine Immunology Pharmacology Drug Discovery Infectious Diseases Pharmacology (medical) SDG 3 - Good Health and Well-being SDG 2 - Zero Hunger SDG 1 - No Poverty |
| description |
Funding Information: Funding: This research was funded by GAVI through the Centers for Disease Control and Prevention (CDC), Atlanta and World Health Organization, Regional Office for Africa (WHO/AFRO). African Research in Neglected Tropical Diseases (EFINTD, grant number 89539); Deutsche Forschungsge-meinschaft (DFG; grant number JO369/5-1); Fundo Nacional de Investigação (FNI); United States Agency for International Development (USAID; grant number AID-656-F-16-00002); the Calouste Gulbenkian Foundation from where A.C., F.M., and J.S. have a PhD fellowship. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-03 2022-03-01T00:00:00Z 2023-01-18T22:17:45Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://hdl.handle.net/10362/147819 |
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eng |
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eng |
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PURE: 50917620 https://doi.org/10.3390/vaccines10030449 |
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