Design of magnetic kappa-carrageenan-collagen bioinks for 3D bioprinting

Bibliographic Details
Main Author: Almeida, Duarte
Publication Date: 2024
Other Authors: Küppers, Freya, Gusmão, Afonso, Manjua, Ana C., Ferreira, Catarina F.R., Portugal, Carla A.M., Silva, João C., Sanjuan-Alberte, Paola, Ferreira, Frederico Castelo
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/178496
Summary: Funding Information: This project also received financial support from \u201Cla Caixa\u201D Foundation (ID 100010434) LCF/BQ/PI22/11910025. Publisher Copyright: © The Author(s) 2024.
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spelling Design of magnetic kappa-carrageenan-collagen bioinks for 3D bioprintingCeramics and CompositesMaterials Science (miscellaneous)Materials Science(all)Mechanics of MaterialsMechanical EngineeringPolymers and PlasticsFunding Information: This project also received financial support from \u201Cla Caixa\u201D Foundation (ID 100010434) LCF/BQ/PI22/11910025. Publisher Copyright: © The Author(s) 2024.Bioprinting approaches are of great promise for tissue engineering applications as they allow the fabrication of constructs able to mimic native tissues’ mechanical and topographical features. Additional control over cells fate can be enhanced using stimuli-responsive materials, requiring the development of novel bioinks for this purpose. In this study, bioinks comprising κ-carrageenan, collagen, and magnetic nanoparticles were designed for 3D bioprinting applications. The characterization of this material was performed, where mechanical compressive tests yielded Young’s moduli ranging from 8.25 to 18.4 kPa. Rheological assessments also revealed the shear-thinning behavior of the bioinks and a temperature-dependent gelation. The capability of these bioinks to produce 3D constructs by extrusion bioprinting was established through the printability evaluation and the development of complex structures, supporting the viability and proliferation of mesenchymal stromal cells (MSCs). Finally, as proof-of-concept, it was observed that the secretome of bioprinted MSCs stimulated with an external magnetic field of 80 mT was able to increase the number of tubes formed by human umbilical vein endothelial cells.LAQV@REQUIMTEDQ - Departamento de QuímicaRUNAlmeida, DuarteKüppers, FreyaGusmão, AfonsoManjua, Ana C.Ferreira, Catarina F.R.Portugal, Carla A.M.Silva, João C.Sanjuan-Alberte, PaolaFerreira, Frederico Castelo2025-02-05T21:19:15Z2024-082024-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article20application/pdfhttp://hdl.handle.net/10362/178496eng0022-2461PURE: 107454396https://doi.org/10.1007/s10853-024-10021-yinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-10T01:33:50Zoai:run.unl.pt:10362/178496Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T19:46:51.423661Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Design of magnetic kappa-carrageenan-collagen bioinks for 3D bioprinting
title Design of magnetic kappa-carrageenan-collagen bioinks for 3D bioprinting
spellingShingle Design of magnetic kappa-carrageenan-collagen bioinks for 3D bioprinting
Almeida, Duarte
Ceramics and Composites
Materials Science (miscellaneous)
Materials Science(all)
Mechanics of Materials
Mechanical Engineering
Polymers and Plastics
title_short Design of magnetic kappa-carrageenan-collagen bioinks for 3D bioprinting
title_full Design of magnetic kappa-carrageenan-collagen bioinks for 3D bioprinting
title_fullStr Design of magnetic kappa-carrageenan-collagen bioinks for 3D bioprinting
title_full_unstemmed Design of magnetic kappa-carrageenan-collagen bioinks for 3D bioprinting
title_sort Design of magnetic kappa-carrageenan-collagen bioinks for 3D bioprinting
author Almeida, Duarte
author_facet Almeida, Duarte
Küppers, Freya
Gusmão, Afonso
Manjua, Ana C.
Ferreira, Catarina F.R.
Portugal, Carla A.M.
Silva, João C.
Sanjuan-Alberte, Paola
Ferreira, Frederico Castelo
author_role author
author2 Küppers, Freya
Gusmão, Afonso
Manjua, Ana C.
Ferreira, Catarina F.R.
Portugal, Carla A.M.
Silva, João C.
Sanjuan-Alberte, Paola
Ferreira, Frederico Castelo
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Almeida, Duarte
Küppers, Freya
Gusmão, Afonso
Manjua, Ana C.
Ferreira, Catarina F.R.
Portugal, Carla A.M.
Silva, João C.
Sanjuan-Alberte, Paola
Ferreira, Frederico Castelo
dc.subject.por.fl_str_mv Ceramics and Composites
Materials Science (miscellaneous)
Materials Science(all)
Mechanics of Materials
Mechanical Engineering
Polymers and Plastics
topic Ceramics and Composites
Materials Science (miscellaneous)
Materials Science(all)
Mechanics of Materials
Mechanical Engineering
Polymers and Plastics
description Funding Information: This project also received financial support from \u201Cla Caixa\u201D Foundation (ID 100010434) LCF/BQ/PI22/11910025. Publisher Copyright: © The Author(s) 2024.
publishDate 2024
dc.date.none.fl_str_mv 2024-08
2024-08-01T00:00:00Z
2025-02-05T21:19:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/178496
url http://hdl.handle.net/10362/178496
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0022-2461
PURE: 107454396
https://doi.org/10.1007/s10853-024-10021-y
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 20
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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