A comparative study to analyse the potential of 99mTc-PEI-MP for diagnosis and 188Re-PEI-MP for therapy of bladder carcinoma and osteosarcoma

Bibliographic Details
Main Author: Ferreira, Sara
Publication Date: 2012
Other Authors: Laranjo, Mafalda, Abrantes, Ana Margarida, Brito, Ana, Metello, Luís F., Zeevart, Jan, Louw, Werner, Dormehl, Irene, Botelho, Maria Filomena
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.22/6627
Summary: Introduction: The water-soluble polymer PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re (emits high energy B- particles) and 99mTc presents a strong potential for metabolic radiotherapy and diagnosis, respectively. The aim of this study was to evaluate in vivo the potential of 188Re-PEI-MP as therapeutic agent and 99mTc-PEI-MP asdiagnostic agent for bladder carcinoma and osteosarcoma. Material and methods: Cytotoxicity of PEI-MP was investigated in bladder carcinoma cell line (CRL-1472) using the MTT test for different concentrations of PEI-MP (1 uM to 1000 uM) and incubation times (24h, 48h, 72h and 96h).
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spelling A comparative study to analyse the potential of 99mTc-PEI-MP for diagnosis and 188Re-PEI-MP for therapy of bladder carcinoma and osteosarcomaIntroduction: The water-soluble polymer PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re (emits high energy B- particles) and 99mTc presents a strong potential for metabolic radiotherapy and diagnosis, respectively. The aim of this study was to evaluate in vivo the potential of 188Re-PEI-MP as therapeutic agent and 99mTc-PEI-MP asdiagnostic agent for bladder carcinoma and osteosarcoma. Material and methods: Cytotoxicity of PEI-MP was investigated in bladder carcinoma cell line (CRL-1472) using the MTT test for different concentrations of PEI-MP (1 uM to 1000 uM) and incubation times (24h, 48h, 72h and 96h).REPOSITÓRIO P.PORTOFerreira, SaraLaranjo, MafaldaAbrantes, Ana MargaridaBrito, AnaMetello, Luís F.Zeevart, JanLouw, WernerDormehl, IreneBotelho, Maria Filomena2015-09-04T11:09:34Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.22/6627enginfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-07T10:14:46Zoai:recipp.ipp.pt:10400.22/6627Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T00:44:16.058901Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv A comparative study to analyse the potential of 99mTc-PEI-MP for diagnosis and 188Re-PEI-MP for therapy of bladder carcinoma and osteosarcoma
title A comparative study to analyse the potential of 99mTc-PEI-MP for diagnosis and 188Re-PEI-MP for therapy of bladder carcinoma and osteosarcoma
spellingShingle A comparative study to analyse the potential of 99mTc-PEI-MP for diagnosis and 188Re-PEI-MP for therapy of bladder carcinoma and osteosarcoma
Ferreira, Sara
title_short A comparative study to analyse the potential of 99mTc-PEI-MP for diagnosis and 188Re-PEI-MP for therapy of bladder carcinoma and osteosarcoma
title_full A comparative study to analyse the potential of 99mTc-PEI-MP for diagnosis and 188Re-PEI-MP for therapy of bladder carcinoma and osteosarcoma
title_fullStr A comparative study to analyse the potential of 99mTc-PEI-MP for diagnosis and 188Re-PEI-MP for therapy of bladder carcinoma and osteosarcoma
title_full_unstemmed A comparative study to analyse the potential of 99mTc-PEI-MP for diagnosis and 188Re-PEI-MP for therapy of bladder carcinoma and osteosarcoma
title_sort A comparative study to analyse the potential of 99mTc-PEI-MP for diagnosis and 188Re-PEI-MP for therapy of bladder carcinoma and osteosarcoma
author Ferreira, Sara
author_facet Ferreira, Sara
Laranjo, Mafalda
Abrantes, Ana Margarida
Brito, Ana
Metello, Luís F.
Zeevart, Jan
Louw, Werner
Dormehl, Irene
Botelho, Maria Filomena
author_role author
author2 Laranjo, Mafalda
Abrantes, Ana Margarida
Brito, Ana
Metello, Luís F.
Zeevart, Jan
Louw, Werner
Dormehl, Irene
Botelho, Maria Filomena
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv REPOSITÓRIO P.PORTO
dc.contributor.author.fl_str_mv Ferreira, Sara
Laranjo, Mafalda
Abrantes, Ana Margarida
Brito, Ana
Metello, Luís F.
Zeevart, Jan
Louw, Werner
Dormehl, Irene
Botelho, Maria Filomena
description Introduction: The water-soluble polymer PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re (emits high energy B- particles) and 99mTc presents a strong potential for metabolic radiotherapy and diagnosis, respectively. The aim of this study was to evaluate in vivo the potential of 188Re-PEI-MP as therapeutic agent and 99mTc-PEI-MP asdiagnostic agent for bladder carcinoma and osteosarcoma. Material and methods: Cytotoxicity of PEI-MP was investigated in bladder carcinoma cell line (CRL-1472) using the MTT test for different concentrations of PEI-MP (1 uM to 1000 uM) and incubation times (24h, 48h, 72h and 96h).
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
2015-09-04T11:09:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/6627
url http://hdl.handle.net/10400.22/6627
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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