Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants

Detalhes bibliográficos
Autor(a) principal: Soares, I.
Data de Publicação: 2022
Outros Autores: Faria, Jaime Moreira Machado, Marques, A. C., Ribeiro, Isabel A. C., Baleizão, Carlos, Bettencourt, Ana F., Ferreira, Isabel, Baptista, Ana Catarina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10362/143209
Resumo: This work was partially funded by the FEDER funds through the COMPETE 2020 Program and National Funds through the FCT – Portuguese Foundation for Science and Technology under the projects UIDB/50025/2020-2023 (CENIMAT/I3N), and also partially supported by the project ERC-CoG-2014. The authors would like to thank the use of the traction machine at the Biomaterials Laboratory from the Soft and Bio-functional Materials Group (CENIMAT/I3N).
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spelling Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic ImplantsChemistry(all)Chemical Engineering(all)SDG 3 - Good Health and Well-beingThis work was partially funded by the FEDER funds through the COMPETE 2020 Program and National Funds through the FCT – Portuguese Foundation for Science and Technology under the projects UIDB/50025/2020-2023 (CENIMAT/I3N), and also partially supported by the project ERC-CoG-2014. The authors would like to thank the use of the traction machine at the Biomaterials Laboratory from the Soft and Bio-functional Materials Group (CENIMAT/I3N).Implant-related infections, mainly caused by Staphylococcus aureus, are a major health concern. Treatment is challenging due to multi-resistant strains and the ability of S. aureus to adhere and form biofilms on bone and implant surfaces. The present work involved the preparation and evaluation of a novel dual polymeric film coating on stainless steel. Chitosan and polycaprolactone (PCL) multilayers, loaded with poly(methyl methacrylate) (PMMA) microspheres encapsulating vancomycin or daptomycin, produced by the dip-coating technique, allowed local antibiotic-controlled delivery for the treatment of implant-related infections. Enhanced adhesion of the film to the metal substrate surface was achieved by mechanical abrasion of its surface. Studies have shown that for both drugs the release occurs by diffusion, but the release profile depends on the type of drug (daptomycin or vancomycin), the pH of the solution, and whether the drug is freestanding (directly incorporated into the films) or encapsulated in PMMA microspheres. Daptomycin freestanding films reached 90% release after 1 day at pH 7.4 and 4 days at pH 5.5. In comparison, films with daptomycin encapsulated microspheres reached 90% release after 2 h at pH 5.5 and 2 days at pH 7.4. Vancomycin encapsulated and freestanding films showed a similar behavior reaching 90% release after 20 h of release at pH 5.5 and 2 and 3 days, respectively, at pH 7.4. Furthermore, daptomycin-loaded films showed activity (assessed by agar diffusion assays) against sensitive (ATCC 25923) and clinically isolated (MRSA) S. aureus strains.DCM - Departamento de Ciência dos MateriaisCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)RUNSoares, I.Faria, Jaime Moreira MachadoMarques, A. C.Ribeiro, Isabel A. C.Baleizão, CarlosBettencourt, Ana F.Ferreira, IsabelBaptista, Ana Catarina2022-08-23T22:18:55Z2022-07-122022-07-12T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://hdl.handle.net/10362/143209eng2470-1343PURE: 45126245https://doi.org/10.1021/acsomega.2c00504info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:04:30Zoai:run.unl.pt:10362/143209Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:35:19.823157Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants
title Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants
spellingShingle Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants
Soares, I.
Chemistry(all)
Chemical Engineering(all)
SDG 3 - Good Health and Well-being
title_short Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants
title_full Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants
title_fullStr Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants
title_full_unstemmed Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants
title_sort Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants
author Soares, I.
author_facet Soares, I.
Faria, Jaime Moreira Machado
Marques, A. C.
Ribeiro, Isabel A. C.
Baleizão, Carlos
Bettencourt, Ana F.
Ferreira, Isabel
Baptista, Ana Catarina
author_role author
author2 Faria, Jaime Moreira Machado
Marques, A. C.
Ribeiro, Isabel A. C.
Baleizão, Carlos
Bettencourt, Ana F.
Ferreira, Isabel
Baptista, Ana Catarina
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DCM - Departamento de Ciência dos Materiais
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
RUN
dc.contributor.author.fl_str_mv Soares, I.
Faria, Jaime Moreira Machado
Marques, A. C.
Ribeiro, Isabel A. C.
Baleizão, Carlos
Bettencourt, Ana F.
Ferreira, Isabel
Baptista, Ana Catarina
dc.subject.por.fl_str_mv Chemistry(all)
Chemical Engineering(all)
SDG 3 - Good Health and Well-being
topic Chemistry(all)
Chemical Engineering(all)
SDG 3 - Good Health and Well-being
description This work was partially funded by the FEDER funds through the COMPETE 2020 Program and National Funds through the FCT – Portuguese Foundation for Science and Technology under the projects UIDB/50025/2020-2023 (CENIMAT/I3N), and also partially supported by the project ERC-CoG-2014. The authors would like to thank the use of the traction machine at the Biomaterials Laboratory from the Soft and Bio-functional Materials Group (CENIMAT/I3N).
publishDate 2022
dc.date.none.fl_str_mv 2022-08-23T22:18:55Z
2022-07-12
2022-07-12T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/143209
url http://hdl.handle.net/10362/143209
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2470-1343
PURE: 45126245
https://doi.org/10.1021/acsomega.2c00504
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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