miRNAs in Heart Development and Disease

Detalhes bibliográficos
Autor(a) principal: Lozano-Velasco, Estefania
Data de Publicação: 2024
Outros Autores: Inácio, José Manuel, Sousa, Inês, Guimarães, Ana Rita, Franco, Diego, Moura, Gabriela, Belo, José António
Tipo de documento: Outros
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10362/163916
Resumo: Funding Information: This work was supported by funds from the Fundação para a Ciência e a Tecnologia (NETDIAMOND-SAICTPAC/0047/2015), iNOVA4Health-UID/Multi/04462/2020, and LS4FUTURE Associated Laboratory (LA/P/0087/2020) to J.A.B. and funds from the Scientific Employment Stimulus to J.M.I. (Norma Transitória 8189/2018). This work was also support by grants from the Ministry of Education and Science of the Spanish Government to D.F. (PID2022-138163OB-C32) and by a grant-in-aid (CTS-446) of the Junta de Andalucia Regional Council. G.M. was funded by FEDER funds (POCI-01-0145-FEDER-022184), CENTRO 2020 (CENTRO-01-0246-FEDER-000018; CENTRO-08-5864-FSE-000039), and by Fundação para a Ciência e a Tecnologia (UIDP/04501/2020; 2022.01376.PTDC). Publisher Copyright: © 2024 by the authors.
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spelling miRNAs in Heart Development and Diseasebioinformatic toolscardiovascular diseasesheart developmentmiRNACatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistrySDG 3 - Good Health and Well-beingFunding Information: This work was supported by funds from the Fundação para a Ciência e a Tecnologia (NETDIAMOND-SAICTPAC/0047/2015), iNOVA4Health-UID/Multi/04462/2020, and LS4FUTURE Associated Laboratory (LA/P/0087/2020) to J.A.B. and funds from the Scientific Employment Stimulus to J.M.I. (Norma Transitória 8189/2018). This work was also support by grants from the Ministry of Education and Science of the Spanish Government to D.F. (PID2022-138163OB-C32) and by a grant-in-aid (CTS-446) of the Junta de Andalucia Regional Council. G.M. was funded by FEDER funds (POCI-01-0145-FEDER-022184), CENTRO 2020 (CENTRO-01-0246-FEDER-000018; CENTRO-08-5864-FSE-000039), and by Fundação para a Ciência e a Tecnologia (UIDP/04501/2020; 2022.01376.PTDC). Publisher Copyright: © 2024 by the authors.Cardiovascular diseases (CVD) are a group of disorders that affect the heart and blood vessels. They include conditions such as myocardial infarction, coronary artery disease, heart failure, arrhythmia, and congenital heart defects. CVDs are the leading cause of death worldwide. Therefore, new medical interventions that aim to prevent, treat, or manage CVDs are of prime importance. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level and play important roles in various biological processes, including cardiac development, function, and disease. Moreover, miRNAs can also act as biomarkers and therapeutic targets. In order to identify and characterize miRNAs and their target genes, scientists take advantage of computational tools such as bioinformatic algorithms, which can also assist in analyzing miRNA expression profiles, functions, and interactions in different cardiac conditions. Indeed, the combination of miRNA research and bioinformatic algorithms has opened new avenues for understanding and treating CVDs. In this review, we summarize the current knowledge on the roles of miRNAs in cardiac development and CVDs, discuss the challenges and opportunities, and provide some examples of recent bioinformatics for miRNA research in cardiovascular biology and medicine.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)iNOVA4Health - pólo NMSRUNLozano-Velasco, EstefaniaInácio, José ManuelSousa, InêsGuimarães, Ana RitaFranco, DiegoMoura, GabrielaBelo, José António2024-02-22T00:11:45Z2024-022024-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/163916eng1661-6596PURE: 83869405https://doi.org/10.3390/ijms25031673info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:18:41Zoai:run.unl.pt:10362/163916Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:49:29.190758Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv miRNAs in Heart Development and Disease
title miRNAs in Heart Development and Disease
spellingShingle miRNAs in Heart Development and Disease
Lozano-Velasco, Estefania
bioinformatic tools
cardiovascular diseases
heart development
miRNA
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
title_short miRNAs in Heart Development and Disease
title_full miRNAs in Heart Development and Disease
title_fullStr miRNAs in Heart Development and Disease
title_full_unstemmed miRNAs in Heart Development and Disease
title_sort miRNAs in Heart Development and Disease
author Lozano-Velasco, Estefania
author_facet Lozano-Velasco, Estefania
Inácio, José Manuel
Sousa, Inês
Guimarães, Ana Rita
Franco, Diego
Moura, Gabriela
Belo, José António
author_role author
author2 Inácio, José Manuel
Sousa, Inês
Guimarães, Ana Rita
Franco, Diego
Moura, Gabriela
Belo, José António
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
iNOVA4Health - pólo NMS
RUN
dc.contributor.author.fl_str_mv Lozano-Velasco, Estefania
Inácio, José Manuel
Sousa, Inês
Guimarães, Ana Rita
Franco, Diego
Moura, Gabriela
Belo, José António
dc.subject.por.fl_str_mv bioinformatic tools
cardiovascular diseases
heart development
miRNA
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
topic bioinformatic tools
cardiovascular diseases
heart development
miRNA
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
description Funding Information: This work was supported by funds from the Fundação para a Ciência e a Tecnologia (NETDIAMOND-SAICTPAC/0047/2015), iNOVA4Health-UID/Multi/04462/2020, and LS4FUTURE Associated Laboratory (LA/P/0087/2020) to J.A.B. and funds from the Scientific Employment Stimulus to J.M.I. (Norma Transitória 8189/2018). This work was also support by grants from the Ministry of Education and Science of the Spanish Government to D.F. (PID2022-138163OB-C32) and by a grant-in-aid (CTS-446) of the Junta de Andalucia Regional Council. G.M. was funded by FEDER funds (POCI-01-0145-FEDER-022184), CENTRO 2020 (CENTRO-01-0246-FEDER-000018; CENTRO-08-5864-FSE-000039), and by Fundação para a Ciência e a Tecnologia (UIDP/04501/2020; 2022.01376.PTDC). Publisher Copyright: © 2024 by the authors.
publishDate 2024
dc.date.none.fl_str_mv 2024-02-22T00:11:45Z
2024-02
2024-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/163916
url http://hdl.handle.net/10362/163916
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1661-6596
PURE: 83869405
https://doi.org/10.3390/ijms25031673
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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