The Role of ARF Family Proteins and Their Regulators and Effectors in Cancer Progression

Detalhes bibliográficos
Autor(a) principal: Casalou, Cristina
Data de Publicação: 2020
Outros Autores: Ferreira, Andreia, Barral, Duarte C.
Tipo de documento: Outros
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10362/97930
Resumo: AF was funded by a Ph.D. fellowship (PD/BD/135506/2018) from the Fundação para a Ciência e a Tecnologia (FCT) and DB by the FCT Investigator Program (IF/00501/2014/CP1252/CT0001).
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spelling The Role of ARF Family Proteins and Their Regulators and Effectors in Cancer ProgressionA Therapeutic PerspectiveARLGTPase-activating proteinguanine nucleotide exchange factorinvasionmembrane trafficmigrationtumorigenesisDevelopmental BiologyCell BiologySDG 3 - Good Health and Well-beingAF was funded by a Ph.D. fellowship (PD/BD/135506/2018) from the Fundação para a Ciência e a Tecnologia (FCT) and DB by the FCT Investigator Program (IF/00501/2014/CP1252/CT0001).The Adenosine diphosphate-Ribosylation Factor (ARF) family belongs to the RAS superfamily of small GTPases and is involved in a wide variety of physiological processes, such as cell proliferation, motility and differentiation by regulating membrane traffic and associating with the cytoskeleton. Like other members of the RAS superfamily, ARF family proteins are activated by Guanine nucleotide Exchange Factors (GEFs) and inactivated by GTPase-Activating Proteins (GAPs). When active, they bind effectors, which mediate downstream functions. Several studies have reported that cancer cells are able to subvert membrane traffic regulators to enhance migration and invasion. Indeed, members of the ARF family, including ARF-Like (ARL) proteins have been implicated in tumorigenesis and progression of several types of cancer. Here, we review the role of ARF family members, their GEFs/GAPs and effectors in tumorigenesis and cancer progression, highlighting the ones that can have a pro-oncogenic behavior or function as tumor suppressors. Moreover, we propose possible mechanisms and approaches to target these proteins, toward the development of novel therapeutic strategies to impair tumor progression.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNCasalou, CristinaFerreira, AndreiaBarral, Duarte C.2020-05-18T22:32:48Z2020-04-212020-04-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/97930engPURE: 18153298https://doi.org/10.3389/fcell.2020.00217info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:45:26Zoai:run.unl.pt:10362/97930Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:16:39.085121Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv The Role of ARF Family Proteins and Their Regulators and Effectors in Cancer Progression
A Therapeutic Perspective
title The Role of ARF Family Proteins and Their Regulators and Effectors in Cancer Progression
spellingShingle The Role of ARF Family Proteins and Their Regulators and Effectors in Cancer Progression
Casalou, Cristina
ARL
GTPase-activating protein
guanine nucleotide exchange factor
invasion
membrane traffic
migration
tumorigenesis
Developmental Biology
Cell Biology
SDG 3 - Good Health and Well-being
title_short The Role of ARF Family Proteins and Their Regulators and Effectors in Cancer Progression
title_full The Role of ARF Family Proteins and Their Regulators and Effectors in Cancer Progression
title_fullStr The Role of ARF Family Proteins and Their Regulators and Effectors in Cancer Progression
title_full_unstemmed The Role of ARF Family Proteins and Their Regulators and Effectors in Cancer Progression
title_sort The Role of ARF Family Proteins and Their Regulators and Effectors in Cancer Progression
author Casalou, Cristina
author_facet Casalou, Cristina
Ferreira, Andreia
Barral, Duarte C.
author_role author
author2 Ferreira, Andreia
Barral, Duarte C.
author2_role author
author
dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Casalou, Cristina
Ferreira, Andreia
Barral, Duarte C.
dc.subject.por.fl_str_mv ARL
GTPase-activating protein
guanine nucleotide exchange factor
invasion
membrane traffic
migration
tumorigenesis
Developmental Biology
Cell Biology
SDG 3 - Good Health and Well-being
topic ARL
GTPase-activating protein
guanine nucleotide exchange factor
invasion
membrane traffic
migration
tumorigenesis
Developmental Biology
Cell Biology
SDG 3 - Good Health and Well-being
description AF was funded by a Ph.D. fellowship (PD/BD/135506/2018) from the Fundação para a Ciência e a Tecnologia (FCT) and DB by the FCT Investigator Program (IF/00501/2014/CP1252/CT0001).
publishDate 2020
dc.date.none.fl_str_mv 2020-05-18T22:32:48Z
2020-04-21
2020-04-21T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/97930
url http://hdl.handle.net/10362/97930
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PURE: 18153298
https://doi.org/10.3389/fcell.2020.00217
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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