Treating rheumatoid arthritis to target : 2014 update of the recommendations of an international task force
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| Publication Date: | 2016 |
| Other Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10451/46769 |
Summary: | This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
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Treating rheumatoid arthritis to target : 2014 update of the recommendations of an international task forceDisease activityEarly rheumatoid arthritisOutcomes researchRheumatoid arthritisTreatmentThis is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/Background: Reaching the therapeutic target of remission or low-disease activity has improved outcomes in patients with rheumatoid arthritis (RA) significantly. The treat-to-target recommendations, formulated in 2010, have provided a basis for implementation of a strategic approach towards this therapeutic goal in routine clinical practice, but these recommendations need to be re-evaluated for appropriateness and practicability in the light of new insights. Objective: To update the 2010 treat-to-target recommendations based on systematic literature reviews (SLR) and expert opinion. Methods: A task force of rheumatologists, patients and a nurse specialist assessed the SLR results and evaluated the individual items of the 2010 recommendations accordingly, reformulating many of the items. These were subsequently discussed, amended and voted upon by >40 experts, including 5 patients, from various regions of the world. Levels of evidence, strengths of recommendations and levels of agreement were derived. Results: The update resulted in 4 overarching principles and 10 recommendations. The previous recommendations were partly adapted and their order changed as deemed appropriate in terms of importance in the view of the experts. The SLR had now provided also data for the effectiveness of targeting low-disease activity or remission in established rather than only early disease. The role of comorbidities, including their potential to preclude treatment intensification, was highlighted more strongly than before. The treatment aim was again defined as remission with low-disease activity being an alternative goal especially in patients with long-standing disease. Regular follow-up (every 1-3 months during active disease) with according therapeutic adaptations to reach the desired state was recommended. Follow-up examinations ought to employ composite measures of disease activity that include joint counts. Additional items provide further details for particular aspects of the disease, especially comorbidity and shared decision-making with the patient. Levels of evidence had increased for many items compared with the 2010 recommendations, and levels of agreement were very high for most of the individual recommendations (≥9/10). Conclusions: The 4 overarching principles and 10 recommendations are based on stronger evidence than before and are supposed to inform patients, rheumatologists and other stakeholders about strategies to reach optimal outcomes of RA.BMJ Publishing Group Ltd.Repositório da Universidade de LisboaSmolen, Josef S.Breedveld, Ferdinand C.Burmester, Gerd R.Bykerk, VivianDougados, MaximeEmery, PaulKvien, Tore K.Navarro-Compán, M VictoriaOliver, SusanSchoels, MonikaScholte-Voshaar, MariekeStamm, TanjaStoffer, MichaelaTakeuchi, TsutomuAletaha, DanielAndreu, Jose LouisAringer, MartinBergman, MartinBetteridge, NeilBijlsma, HansBurkhardt, HaraldCardiel, MarioCombe, BernardDurez, PatrickFonseca, João EuricoGibofsky, AlanGomez-Reino, Juan J.Graninger, WinfriedHannonen, PekkaHaraoui, BoulosKouloumas, MariosLandewe, RobertMartin-Mola, EmilioNash, PeterOstergaard, MikkelÖstör, AndrewRichards, PamSokka-Isler, TuulikkiThorne, CarterTzioufas, Athanasios G.van Vollenhoven, Ronaldde Wit, Martinusvan der Heijde, Desirée2021-03-10T12:32:59Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46769engAnn Rheum Dis. 2016 Jan;75(1):3-150003-496710.1136/annrheumdis-2015-2075241468-2060info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:29:33Zoai:repositorio.ulisboa.pt:10451/46769Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:13:39.345306Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Treating rheumatoid arthritis to target : 2014 update of the recommendations of an international task force |
| title |
Treating rheumatoid arthritis to target : 2014 update of the recommendations of an international task force |
| spellingShingle |
Treating rheumatoid arthritis to target : 2014 update of the recommendations of an international task force Smolen, Josef S. Disease activity Early rheumatoid arthritis Outcomes research Rheumatoid arthritis Treatment |
| title_short |
Treating rheumatoid arthritis to target : 2014 update of the recommendations of an international task force |
| title_full |
Treating rheumatoid arthritis to target : 2014 update of the recommendations of an international task force |
| title_fullStr |
Treating rheumatoid arthritis to target : 2014 update of the recommendations of an international task force |
| title_full_unstemmed |
Treating rheumatoid arthritis to target : 2014 update of the recommendations of an international task force |
| title_sort |
Treating rheumatoid arthritis to target : 2014 update of the recommendations of an international task force |
| author |
Smolen, Josef S. |
| author_facet |
Smolen, Josef S. Breedveld, Ferdinand C. Burmester, Gerd R. Bykerk, Vivian Dougados, Maxime Emery, Paul Kvien, Tore K. Navarro-Compán, M Victoria Oliver, Susan Schoels, Monika Scholte-Voshaar, Marieke Stamm, Tanja Stoffer, Michaela Takeuchi, Tsutomu Aletaha, Daniel Andreu, Jose Louis Aringer, Martin Bergman, Martin Betteridge, Neil Bijlsma, Hans Burkhardt, Harald Cardiel, Mario Combe, Bernard Durez, Patrick Fonseca, João Eurico Gibofsky, Alan Gomez-Reino, Juan J. Graninger, Winfried Hannonen, Pekka Haraoui, Boulos Kouloumas, Marios Landewe, Robert Martin-Mola, Emilio Nash, Peter Ostergaard, Mikkel Östör, Andrew Richards, Pam Sokka-Isler, Tuulikki Thorne, Carter Tzioufas, Athanasios G. van Vollenhoven, Ronald de Wit, Martinus van der Heijde, Desirée |
| author_role |
author |
| author2 |
Breedveld, Ferdinand C. Burmester, Gerd R. Bykerk, Vivian Dougados, Maxime Emery, Paul Kvien, Tore K. Navarro-Compán, M Victoria Oliver, Susan Schoels, Monika Scholte-Voshaar, Marieke Stamm, Tanja Stoffer, Michaela Takeuchi, Tsutomu Aletaha, Daniel Andreu, Jose Louis Aringer, Martin Bergman, Martin Betteridge, Neil Bijlsma, Hans Burkhardt, Harald Cardiel, Mario Combe, Bernard Durez, Patrick Fonseca, João Eurico Gibofsky, Alan Gomez-Reino, Juan J. Graninger, Winfried Hannonen, Pekka Haraoui, Boulos Kouloumas, Marios Landewe, Robert Martin-Mola, Emilio Nash, Peter Ostergaard, Mikkel Östör, Andrew Richards, Pam Sokka-Isler, Tuulikki Thorne, Carter Tzioufas, Athanasios G. van Vollenhoven, Ronald de Wit, Martinus van der Heijde, Desirée |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Smolen, Josef S. Breedveld, Ferdinand C. Burmester, Gerd R. Bykerk, Vivian Dougados, Maxime Emery, Paul Kvien, Tore K. Navarro-Compán, M Victoria Oliver, Susan Schoels, Monika Scholte-Voshaar, Marieke Stamm, Tanja Stoffer, Michaela Takeuchi, Tsutomu Aletaha, Daniel Andreu, Jose Louis Aringer, Martin Bergman, Martin Betteridge, Neil Bijlsma, Hans Burkhardt, Harald Cardiel, Mario Combe, Bernard Durez, Patrick Fonseca, João Eurico Gibofsky, Alan Gomez-Reino, Juan J. Graninger, Winfried Hannonen, Pekka Haraoui, Boulos Kouloumas, Marios Landewe, Robert Martin-Mola, Emilio Nash, Peter Ostergaard, Mikkel Östör, Andrew Richards, Pam Sokka-Isler, Tuulikki Thorne, Carter Tzioufas, Athanasios G. van Vollenhoven, Ronald de Wit, Martinus van der Heijde, Desirée |
| dc.subject.por.fl_str_mv |
Disease activity Early rheumatoid arthritis Outcomes research Rheumatoid arthritis Treatment |
| topic |
Disease activity Early rheumatoid arthritis Outcomes research Rheumatoid arthritis Treatment |
| description |
This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| publishDate |
2016 |
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2016 2016-01-01T00:00:00Z 2021-03-10T12:32:59Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/46769 |
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http://hdl.handle.net/10451/46769 |
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eng |
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eng |
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Ann Rheum Dis. 2016 Jan;75(1):3-15 0003-4967 10.1136/annrheumdis-2015-207524 1468-2060 |
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BMJ Publishing Group Ltd. |
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BMJ Publishing Group Ltd. |
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