Challenges in Antibody Development against Tn and Sialyl-Tn Antigens
| Main Author: | |
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| Publication Date: | 2015 |
| Other Authors: | , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/36960 |
Summary: | PMID: 26270678 PMCID:4598775 |
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Challenges in Antibody Development against Tn and Sialyl-Tn AntigensAnimalsAntibodiesAntigens, Tumor-Associated, CarbohydrateGenetic EngineeringHumansImmunotherapyNeoplasmsJournal ArticleResearch Support, Non-U.S. Gov'tReviewSDG 3 - Good Health and Well-beingPMID: 26270678 PMCID:4598775The carbohydrate antigens Tn and sialyl-Tn (STn) are expressed in most carcinomas and usually absent in healthy tissues. These antigens have been correlated with cancer progression and poor prognosis, and associated with immunosuppressive microenvironment. Presently they are used in clinical trials as therapeutic vaccination, but with limited success due to their low immunogenicity. Alternatively, anti-Tn and/or STn antibodies may be used to harness the immune system against tumor cells. Whilst the development of antibodies against these antigens had a boost two decades ago for diagnostic use, so far no such antibody entered into clinical trials. Possible limitations are the low specificity and efficiency of existing antibodies and that novel antibodies are still necessary. The vast array of methodologies available today will allow rapid antibody development and novel formats. Following the advent of hybridoma technology, the immortalization of human B cells became a methodology to obtain human monoclonal antibodies with better specificity. Advances in molecular biology including phage display technology for high throughput screening, transgenic mice and more recently molecularly engineered antibodies enhanced the field of antibody production. The development of novel antibodies against Tn and STn taking advantage of innovative technologies and engineering techniques may result in innovative therapeutic antibodies for cancer treatment.Centro de Estudos de Doenças Crónicas (CEDOC)Instituto de Higiene e Medicina Tropical (IHMT)DCV - Departamento de Ciências da VidaUCIBIO - Applied Molecular Biosciences UnitNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNLoureiro, Liliana RCarrascal, Mylène ABarbas, AnaRamalho, José SNovo, CarlosDelannoy, PhilippeVideira, Paula A2018-05-14T22:03:10Z2015-08-112015-08-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article27application/pdfhttp://hdl.handle.net/10362/36960eng2218-273XPURE: 1815250https://doi.org/10.3390/biom5031783info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:32:52Zoai:run.unl.pt:10362/36960Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:03:45.271086Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Challenges in Antibody Development against Tn and Sialyl-Tn Antigens |
| title |
Challenges in Antibody Development against Tn and Sialyl-Tn Antigens |
| spellingShingle |
Challenges in Antibody Development against Tn and Sialyl-Tn Antigens Loureiro, Liliana R Animals Antibodies Antigens, Tumor-Associated, Carbohydrate Genetic Engineering Humans Immunotherapy Neoplasms Journal Article Research Support, Non-U.S. Gov't Review SDG 3 - Good Health and Well-being |
| title_short |
Challenges in Antibody Development against Tn and Sialyl-Tn Antigens |
| title_full |
Challenges in Antibody Development against Tn and Sialyl-Tn Antigens |
| title_fullStr |
Challenges in Antibody Development against Tn and Sialyl-Tn Antigens |
| title_full_unstemmed |
Challenges in Antibody Development against Tn and Sialyl-Tn Antigens |
| title_sort |
Challenges in Antibody Development against Tn and Sialyl-Tn Antigens |
| author |
Loureiro, Liliana R |
| author_facet |
Loureiro, Liliana R Carrascal, Mylène A Barbas, Ana Ramalho, José S Novo, Carlos Delannoy, Philippe Videira, Paula A |
| author_role |
author |
| author2 |
Carrascal, Mylène A Barbas, Ana Ramalho, José S Novo, Carlos Delannoy, Philippe Videira, Paula A |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Centro de Estudos de Doenças Crónicas (CEDOC) Instituto de Higiene e Medicina Tropical (IHMT) DCV - Departamento de Ciências da Vida UCIBIO - Applied Molecular Biosciences Unit NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Loureiro, Liliana R Carrascal, Mylène A Barbas, Ana Ramalho, José S Novo, Carlos Delannoy, Philippe Videira, Paula A |
| dc.subject.por.fl_str_mv |
Animals Antibodies Antigens, Tumor-Associated, Carbohydrate Genetic Engineering Humans Immunotherapy Neoplasms Journal Article Research Support, Non-U.S. Gov't Review SDG 3 - Good Health and Well-being |
| topic |
Animals Antibodies Antigens, Tumor-Associated, Carbohydrate Genetic Engineering Humans Immunotherapy Neoplasms Journal Article Research Support, Non-U.S. Gov't Review SDG 3 - Good Health and Well-being |
| description |
PMID: 26270678 PMCID:4598775 |
| publishDate |
2015 |
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2015-08-11 2015-08-11T00:00:00Z 2018-05-14T22:03:10Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://hdl.handle.net/10362/36960 |
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http://hdl.handle.net/10362/36960 |
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eng |
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eng |
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2218-273X PURE: 1815250 https://doi.org/10.3390/biom5031783 |
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