Centrioles: active players or passengers during mitosis?

Detalhes bibliográficos
Autor(a) principal: Debec, Alain
Data de Publicação: 2010
Outros Autores: Sullivan, William, Bettencourt-Dias, Monica
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10400.7/750
Resumo: Centrioles are cylinders made of nine microtubule (MT) triplets present in many eukaryotes. Early studies, where centrosomes were seen at the poles of the mitotic spindle led to their coining as "the organ for cell division". However, a variety of subsequent observational and functional studies showed that centrosomes might not always be essential for mitosis. Here we review the arguments in this debate. We describe the centriole structure and its distribution in the eukaryotic tree of life and clarify its role in the organization of the centrosome and cilia, with an historical perspective. An important aspect of the debate addressed in this review is how centrioles are inherited and the role of the spindle in this process. In particular, germline inheritance of centrosomes, such as their de novo formation in parthenogenetic species, poses many interesting questions. We finish by discussing the most likely functions of centrioles and laying out new research avenues.
id RCAP_c68573d9aa8fb1e6be56c24b4f22b85e
oai_identifier_str oai:arca.igc.gulbenkian.pt:10400.7/750
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Centrioles: active players or passengers during mitosis?AnimalsCell DivisionCell LineCentriolesCentrosomeCiliaDrosophilaMicrotubulesParthenogenesisSpindle ApparatusMitosisCentrioles are cylinders made of nine microtubule (MT) triplets present in many eukaryotes. Early studies, where centrosomes were seen at the poles of the mitotic spindle led to their coining as "the organ for cell division". However, a variety of subsequent observational and functional studies showed that centrosomes might not always be essential for mitosis. Here we review the arguments in this debate. We describe the centriole structure and its distribution in the eukaryotic tree of life and clarify its role in the organization of the centrosome and cilia, with an historical perspective. An important aspect of the debate addressed in this review is how centrioles are inherited and the role of the spindle in this process. In particular, germline inheritance of centrosomes, such as their de novo formation in parthenogenetic species, poses many interesting questions. We finish by discussing the most likely functions of centrioles and laying out new research avenues.Springer VerlagARCADebec, AlainSullivan, WilliamBettencourt-Dias, Monica2017-05-04T16:28:29Z2010-03-192010-03-19T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/750eng10.1007/s00018-010-0323-9info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-11-21T14:21:36Zoai:arca.igc.gulbenkian.pt:10400.7/750Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T19:15:23.525638Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Centrioles: active players or passengers during mitosis?
title Centrioles: active players or passengers during mitosis?
spellingShingle Centrioles: active players or passengers during mitosis?
Debec, Alain
Animals
Cell Division
Cell Line
Centrioles
Centrosome
Cilia
Drosophila
Microtubules
Parthenogenesis
Spindle Apparatus
Mitosis
title_short Centrioles: active players or passengers during mitosis?
title_full Centrioles: active players or passengers during mitosis?
title_fullStr Centrioles: active players or passengers during mitosis?
title_full_unstemmed Centrioles: active players or passengers during mitosis?
title_sort Centrioles: active players or passengers during mitosis?
author Debec, Alain
author_facet Debec, Alain
Sullivan, William
Bettencourt-Dias, Monica
author_role author
author2 Sullivan, William
Bettencourt-Dias, Monica
author2_role author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Debec, Alain
Sullivan, William
Bettencourt-Dias, Monica
dc.subject.por.fl_str_mv Animals
Cell Division
Cell Line
Centrioles
Centrosome
Cilia
Drosophila
Microtubules
Parthenogenesis
Spindle Apparatus
Mitosis
topic Animals
Cell Division
Cell Line
Centrioles
Centrosome
Cilia
Drosophila
Microtubules
Parthenogenesis
Spindle Apparatus
Mitosis
description Centrioles are cylinders made of nine microtubule (MT) triplets present in many eukaryotes. Early studies, where centrosomes were seen at the poles of the mitotic spindle led to their coining as "the organ for cell division". However, a variety of subsequent observational and functional studies showed that centrosomes might not always be essential for mitosis. Here we review the arguments in this debate. We describe the centriole structure and its distribution in the eukaryotic tree of life and clarify its role in the organization of the centrosome and cilia, with an historical perspective. An important aspect of the debate addressed in this review is how centrioles are inherited and the role of the spindle in this process. In particular, germline inheritance of centrosomes, such as their de novo formation in parthenogenetic species, poses many interesting questions. We finish by discussing the most likely functions of centrioles and laying out new research avenues.
publishDate 2010
dc.date.none.fl_str_mv 2010-03-19
2010-03-19T00:00:00Z
2017-05-04T16:28:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/750
url http://hdl.handle.net/10400.7/750
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1007/s00018-010-0323-9
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833597973918908416

Registros relacionados