Plasmodium falciparum Plasmepsin 2 Duplications, West Africa

Bibliographic Details
Main Author: Inoue, Juliana
Publication Date: 2018
Other Authors: Silva, Miguel, Fofana, Bakary, Sanogo, Kassim, Mårtensson, Andreas, Sagara, Issaka, Björkman, Anders, Veiga, Maria Isabel, Ferreira, Pedro Eduardo, Djimde, Abdoulaye, Gil, José Pedro
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/1822/58099
Summary: Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in Africa.
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spelling Plasmodium falciparum Plasmepsin 2 Duplications, West AfricaScience & TechnologyDihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in Africa.This work was supported by a Swedish Research Council Grant (no. VR-2014-3134). The WANECAM study is funded by the European and Developing Countries Clinical Trial Partnership and by the Medicines for Malaria Venture (Geneva, Switzerland) and is co-funded by the United Kingdom Medical Research Councils, the Swedish International Development Cooperation Agency, the German Ministry for Education and Research, the University Claude Bernard (Lyon, France), the University of Science, Techniques, and Technologies of Bamako (Bamako, Mali), the Centre National de Recherche et de Formation sur le Paludisme (Burkina Faso), the Institut de Recherche en Sciences de la Sante (Bobo-Dioulasso, Burkina Faso), and the Centre National de Formation et de Recherche en Sante Rurale (Guinea).J.I. was supported by EuroInkaNet/Erasmus Mundus Program. Fundacao para a Ciencia e Tecnologia supports M.S. (grant no. SFRH/BD/129769/2017), M.I.V. (grant no. SFRH/BPD/76614/2011), and P.E.F. (grant no. IF/00143/2015).Centers for Disease Control and Prevention (CDC)Universidade do MinhoInoue, JulianaSilva, MiguelFofana, BakarySanogo, KassimMårtensson, AndreasSagara, IssakaBjörkman, AndersVeiga, Maria IsabelFerreira, Pedro EduardoDjimde, AbdoulayeGil, José Pedro20182018-01-01T00:00:00Zletter to the editorinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/1822/58099eng1080-604010.3201/eid2408.18037029798744info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T05:47:41Zoai:repositorium.sdum.uminho.pt:1822/58099Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T15:30:21.472642Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
title Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
spellingShingle Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
Inoue, Juliana
Science & Technology
title_short Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
title_full Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
title_fullStr Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
title_full_unstemmed Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
title_sort Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
author Inoue, Juliana
author_facet Inoue, Juliana
Silva, Miguel
Fofana, Bakary
Sanogo, Kassim
Mårtensson, Andreas
Sagara, Issaka
Björkman, Anders
Veiga, Maria Isabel
Ferreira, Pedro Eduardo
Djimde, Abdoulaye
Gil, José Pedro
author_role author
author2 Silva, Miguel
Fofana, Bakary
Sanogo, Kassim
Mårtensson, Andreas
Sagara, Issaka
Björkman, Anders
Veiga, Maria Isabel
Ferreira, Pedro Eduardo
Djimde, Abdoulaye
Gil, José Pedro
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Inoue, Juliana
Silva, Miguel
Fofana, Bakary
Sanogo, Kassim
Mårtensson, Andreas
Sagara, Issaka
Björkman, Anders
Veiga, Maria Isabel
Ferreira, Pedro Eduardo
Djimde, Abdoulaye
Gil, José Pedro
dc.subject.por.fl_str_mv Science & Technology
topic Science & Technology
description Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in Africa.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
dc.type.driver.fl_str_mv letter to the editor
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/58099
url http://hdl.handle.net/1822/58099
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1080-6040
10.3201/eid2408.180370
29798744
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Centers for Disease Control and Prevention (CDC)
publisher.none.fl_str_mv Centers for Disease Control and Prevention (CDC)
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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