Bone morphogenetic proteins in tissue engineering: the road from laboratory to the clinic: part I (basic concepts)

Bibliographic Details
Main Author: Bessa, Paulo C.
Publication Date: 2008
Other Authors: Casal, Margarida, Reis, R. L.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/1822/13420
Summary: Discovered in 1965, bone morphogenetic proteins (BMPs) are a group of cytokines from the transforming growth factor-β (TGFβ) superfamily with significant roles in bone and cartilage formation. BMPs are used as powerful osteoinductive components of diverse tissue-engineering products for the healing of bone. Several BMPs with different physiological roles have been identified in humans. The purpose of this review is to cover the biological function of the main members of BMP family, the latest research on BMPs signalling pathways and advances in the production of recombinant BMPs for tissue engineering purposes.
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spelling Bone morphogenetic proteins in tissue engineering: the road from laboratory to the clinic: part I (basic concepts)Bone morphogenetic proteinsBone morphogenetic protein receptorSmad signallingBMP signallingRecombinant BMPTissue engineeringScience & TechnologyDiscovered in 1965, bone morphogenetic proteins (BMPs) are a group of cytokines from the transforming growth factor-β (TGFβ) superfamily with significant roles in bone and cartilage formation. BMPs are used as powerful osteoinductive components of diverse tissue-engineering products for the healing of bone. Several BMPs with different physiological roles have been identified in humans. The purpose of this review is to cover the biological function of the main members of BMP family, the latest research on BMPs signalling pathways and advances in the production of recombinant BMPs for tissue engineering purposes.WileyUniversidade do MinhoBessa, Paulo C.Casal, MargaridaReis, R. L.20082008-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/13420eng1932-625410.1002/term.6318293427info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T04:19:54Zoai:repositorium.sdum.uminho.pt:1822/13420Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T14:45:42.870348Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Bone morphogenetic proteins in tissue engineering: the road from laboratory to the clinic: part I (basic concepts)
title Bone morphogenetic proteins in tissue engineering: the road from laboratory to the clinic: part I (basic concepts)
spellingShingle Bone morphogenetic proteins in tissue engineering: the road from laboratory to the clinic: part I (basic concepts)
Bessa, Paulo C.
Bone morphogenetic proteins
Bone morphogenetic protein receptor
Smad signalling
BMP signalling
Recombinant BMP
Tissue engineering
Science & Technology
title_short Bone morphogenetic proteins in tissue engineering: the road from laboratory to the clinic: part I (basic concepts)
title_full Bone morphogenetic proteins in tissue engineering: the road from laboratory to the clinic: part I (basic concepts)
title_fullStr Bone morphogenetic proteins in tissue engineering: the road from laboratory to the clinic: part I (basic concepts)
title_full_unstemmed Bone morphogenetic proteins in tissue engineering: the road from laboratory to the clinic: part I (basic concepts)
title_sort Bone morphogenetic proteins in tissue engineering: the road from laboratory to the clinic: part I (basic concepts)
author Bessa, Paulo C.
author_facet Bessa, Paulo C.
Casal, Margarida
Reis, R. L.
author_role author
author2 Casal, Margarida
Reis, R. L.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Bessa, Paulo C.
Casal, Margarida
Reis, R. L.
dc.subject.por.fl_str_mv Bone morphogenetic proteins
Bone morphogenetic protein receptor
Smad signalling
BMP signalling
Recombinant BMP
Tissue engineering
Science & Technology
topic Bone morphogenetic proteins
Bone morphogenetic protein receptor
Smad signalling
BMP signalling
Recombinant BMP
Tissue engineering
Science & Technology
description Discovered in 1965, bone morphogenetic proteins (BMPs) are a group of cytokines from the transforming growth factor-β (TGFβ) superfamily with significant roles in bone and cartilage formation. BMPs are used as powerful osteoinductive components of diverse tissue-engineering products for the healing of bone. Several BMPs with different physiological roles have been identified in humans. The purpose of this review is to cover the biological function of the main members of BMP family, the latest research on BMPs signalling pathways and advances in the production of recombinant BMPs for tissue engineering purposes.
publishDate 2008
dc.date.none.fl_str_mv 2008
2008-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/13420
url http://hdl.handle.net/1822/13420
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1932-6254
10.1002/term.63
18293427
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833594867864829952

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