C3 glomerulonephritis disguised as Postinfectious GN

Detalhes bibliográficos
Autor(a) principal: Lança,Alice
Data de Publicação: 2018
Outros Autores: Santos,Paulo, Lopes,Karina, Ferrer,Francisco, Vila Lobos,Ana
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692018000100010
Resumo: It is not uncommon for atypical cases of postinfectious glomerulonephritis (PIGN) to be confused with C3 glomerulonephritis (C3GN) due to considerable overlap of their clinical and histopathological features. We present a case of a 42-year-old man who was hospitalized with hematuria and worsening renal function after an episode of pharyngitis. Following a complete negative serological examination, the indolent clinical course associated with the findings of diffuse proliferative and exudative glomerulonephritis with dominant C3 staining and subendothelial and mesangial electron-dense deposits on the kidney biopsy were fundamental for the final diagnosis. The genetic test identified two mutations involved in the alternative complement pathway. Steroids and mycophenolate mofetil were initiated with improved renal function. This case alerts us that the presence of atypical clinical or histological features of apparent PIGN should raise suspicion of C3 glomerulopathy (C3G) because only a correct diagnosis will allow adequate treatment and a better long-term prognosis
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spelling C3 glomerulonephritis disguised as Postinfectious GNC3 glomerulonephritisChronic Kidney DiseasePostinfectious glomerulonephritisIt is not uncommon for atypical cases of postinfectious glomerulonephritis (PIGN) to be confused with C3 glomerulonephritis (C3GN) due to considerable overlap of their clinical and histopathological features. We present a case of a 42-year-old man who was hospitalized with hematuria and worsening renal function after an episode of pharyngitis. Following a complete negative serological examination, the indolent clinical course associated with the findings of diffuse proliferative and exudative glomerulonephritis with dominant C3 staining and subendothelial and mesangial electron-dense deposits on the kidney biopsy were fundamental for the final diagnosis. The genetic test identified two mutations involved in the alternative complement pathway. Steroids and mycophenolate mofetil were initiated with improved renal function. This case alerts us that the presence of atypical clinical or histological features of apparent PIGN should raise suspicion of C3 glomerulopathy (C3G) because only a correct diagnosis will allow adequate treatment and a better long-term prognosisSociedade Portuguesa de Nefrologia2018-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692018000100010Portuguese Journal of Nephrology & Hypertension v.32 n.1 2018reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692018000100010Lança,AliceSantos,PauloLopes,KarinaFerrer,FranciscoVila Lobos,Anainfo:eu-repo/semantics/openAccess2024-02-06T17:04:57Zoai:scielo:S0872-01692018000100010Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T12:54:31.715330Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv C3 glomerulonephritis disguised as Postinfectious GN
title C3 glomerulonephritis disguised as Postinfectious GN
spellingShingle C3 glomerulonephritis disguised as Postinfectious GN
Lança,Alice
C3 glomerulonephritis
Chronic Kidney Disease
Postinfectious glomerulonephritis
title_short C3 glomerulonephritis disguised as Postinfectious GN
title_full C3 glomerulonephritis disguised as Postinfectious GN
title_fullStr C3 glomerulonephritis disguised as Postinfectious GN
title_full_unstemmed C3 glomerulonephritis disguised as Postinfectious GN
title_sort C3 glomerulonephritis disguised as Postinfectious GN
author Lança,Alice
author_facet Lança,Alice
Santos,Paulo
Lopes,Karina
Ferrer,Francisco
Vila Lobos,Ana
author_role author
author2 Santos,Paulo
Lopes,Karina
Ferrer,Francisco
Vila Lobos,Ana
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Lança,Alice
Santos,Paulo
Lopes,Karina
Ferrer,Francisco
Vila Lobos,Ana
dc.subject.por.fl_str_mv C3 glomerulonephritis
Chronic Kidney Disease
Postinfectious glomerulonephritis
topic C3 glomerulonephritis
Chronic Kidney Disease
Postinfectious glomerulonephritis
description It is not uncommon for atypical cases of postinfectious glomerulonephritis (PIGN) to be confused with C3 glomerulonephritis (C3GN) due to considerable overlap of their clinical and histopathological features. We present a case of a 42-year-old man who was hospitalized with hematuria and worsening renal function after an episode of pharyngitis. Following a complete negative serological examination, the indolent clinical course associated with the findings of diffuse proliferative and exudative glomerulonephritis with dominant C3 staining and subendothelial and mesangial electron-dense deposits on the kidney biopsy were fundamental for the final diagnosis. The genetic test identified two mutations involved in the alternative complement pathway. Steroids and mycophenolate mofetil were initiated with improved renal function. This case alerts us that the presence of atypical clinical or histological features of apparent PIGN should raise suspicion of C3 glomerulopathy (C3G) because only a correct diagnosis will allow adequate treatment and a better long-term prognosis
publishDate 2018
dc.date.none.fl_str_mv 2018-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692018000100010
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692018000100010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692018000100010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
dc.source.none.fl_str_mv Portuguese Journal of Nephrology & Hypertension v.32 n.1 2018
reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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