Design of RAFT synthesized amphiphilic and stimuli-responsive block copolymers for encapsulation of polyphenols in polymersomes

Detalhes bibliográficos
Autor(a) principal: Gomes, Catarina
Data de Publicação: 2018
Outros Autores: Dias, Rolando, Costa, Mário Rui
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10198/18039
Resumo: This research is devoted to the design and synthesis of amphiphilic/stimuli-responsive block copolymers for encapsulation of polyphenols in polymersomes. The Reversible Addition- Fragmentation Chain Transfer (RAFT) polymerization technique is used to get tailored amphiphilic block copolymers. Multiple combinations between hydrophilic/hydrophobic monomers, RAFT agents and initial compositions are the main design variables of the synthesis runs. Experimental studies are guided by modeling tools to aid in the design of the materials (e.g. to specify the sizes of the two blocks, pH sensitivity). Isolated polyphenols (e.g. resveratrol, quercetin) and more complex extracts from different kinds of plants are afterwards encapsulated in polymersomes, aiming at the development of carriers for protection and controlled release of these bioactive compounds. It is shown that the produced aggregates have a long colloidal stability and are promising vehicles for the stimulatedrelease of polyphenols.
id RCAP_ad9a5137e18e3d6b4c44af72e7e9be8c
oai_identifier_str oai:bibliotecadigital.ipb.pt:10198/18039
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Design of RAFT synthesized amphiphilic and stimuli-responsive block copolymers for encapsulation of polyphenols in polymersomesRAFT polymerizationBlock CopolymersAmphiphilic block copolymersStimuli-responsive block copolymersPolymersomesPolyphenolsThis research is devoted to the design and synthesis of amphiphilic/stimuli-responsive block copolymers for encapsulation of polyphenols in polymersomes. The Reversible Addition- Fragmentation Chain Transfer (RAFT) polymerization technique is used to get tailored amphiphilic block copolymers. Multiple combinations between hydrophilic/hydrophobic monomers, RAFT agents and initial compositions are the main design variables of the synthesis runs. Experimental studies are guided by modeling tools to aid in the design of the materials (e.g. to specify the sizes of the two blocks, pH sensitivity). Isolated polyphenols (e.g. resveratrol, quercetin) and more complex extracts from different kinds of plants are afterwards encapsulated in polymersomes, aiming at the development of carriers for protection and controlled release of these bioactive compounds. It is shown that the produced aggregates have a long colloidal stability and are promising vehicles for the stimulatedrelease of polyphenols.This work is a result of project “AIProcMat@N2020—Advanced Industrial Processes and Materials for a Sustainable Northern Region of Portugal 2020,” with the reference NORTE-01-0145-FEDER-000006, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and of Project POCI-01-0145-FEDER-006984-Associate Laboratory LSRE-LCM funded by ERDF through COMPETE2020- Programa Operacional Competitividade e Internacionalização (POCI)-and by national funds through FCT-Fundação para a Ciência e a TecnologiaBiblioteca Digital do IPBGomes, CatarinaDias, RolandoCosta, Mário Rui2018-10-10T13:35:12Z20182018-01-01T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10198/18039enginfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-25T12:08:20Zoai:bibliotecadigital.ipb.pt:10198/18039Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T11:34:52.771285Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Design of RAFT synthesized amphiphilic and stimuli-responsive block copolymers for encapsulation of polyphenols in polymersomes
title Design of RAFT synthesized amphiphilic and stimuli-responsive block copolymers for encapsulation of polyphenols in polymersomes
spellingShingle Design of RAFT synthesized amphiphilic and stimuli-responsive block copolymers for encapsulation of polyphenols in polymersomes
Gomes, Catarina
RAFT polymerization
Block Copolymers
Amphiphilic block copolymers
Stimuli-responsive block copolymers
Polymersomes
Polyphenols
title_short Design of RAFT synthesized amphiphilic and stimuli-responsive block copolymers for encapsulation of polyphenols in polymersomes
title_full Design of RAFT synthesized amphiphilic and stimuli-responsive block copolymers for encapsulation of polyphenols in polymersomes
title_fullStr Design of RAFT synthesized amphiphilic and stimuli-responsive block copolymers for encapsulation of polyphenols in polymersomes
title_full_unstemmed Design of RAFT synthesized amphiphilic and stimuli-responsive block copolymers for encapsulation of polyphenols in polymersomes
title_sort Design of RAFT synthesized amphiphilic and stimuli-responsive block copolymers for encapsulation of polyphenols in polymersomes
author Gomes, Catarina
author_facet Gomes, Catarina
Dias, Rolando
Costa, Mário Rui
author_role author
author2 Dias, Rolando
Costa, Mário Rui
author2_role author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Gomes, Catarina
Dias, Rolando
Costa, Mário Rui
dc.subject.por.fl_str_mv RAFT polymerization
Block Copolymers
Amphiphilic block copolymers
Stimuli-responsive block copolymers
Polymersomes
Polyphenols
topic RAFT polymerization
Block Copolymers
Amphiphilic block copolymers
Stimuli-responsive block copolymers
Polymersomes
Polyphenols
description This research is devoted to the design and synthesis of amphiphilic/stimuli-responsive block copolymers for encapsulation of polyphenols in polymersomes. The Reversible Addition- Fragmentation Chain Transfer (RAFT) polymerization technique is used to get tailored amphiphilic block copolymers. Multiple combinations between hydrophilic/hydrophobic monomers, RAFT agents and initial compositions are the main design variables of the synthesis runs. Experimental studies are guided by modeling tools to aid in the design of the materials (e.g. to specify the sizes of the two blocks, pH sensitivity). Isolated polyphenols (e.g. resveratrol, quercetin) and more complex extracts from different kinds of plants are afterwards encapsulated in polymersomes, aiming at the development of carriers for protection and controlled release of these bioactive compounds. It is shown that the produced aggregates have a long colloidal stability and are promising vehicles for the stimulatedrelease of polyphenols.
publishDate 2018
dc.date.none.fl_str_mv 2018-10-10T13:35:12Z
2018
2018-01-01T00:00:00Z
dc.type.driver.fl_str_mv conference object
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/18039
url http://hdl.handle.net/10198/18039
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833592040264302592

Registros relacionados