RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6

Bibliographic Details
Main Author: Durkin, Charlotte H
Publication Date: 2017
Other Authors: Leite, Flavia, Cordeiro, João V, Handa, Yutaka, Arakawa, Yoshiki, Valderrama, Ferran, Way, Michael
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/31435
Summary: Copyright © 2017 The Francis Crick Institute. Published by Elsevier Inc. All rights reserved.
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spelling RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6Journal ArticleSDG 3 - Good Health and Well-beingCopyright © 2017 The Francis Crick Institute. Published by Elsevier Inc. All rights reserved.RhoA-mediated regulation of myosin-II activity in the actin cortex controls the ability of cells to contract and bleb during a variety of cellular processes, including cell migration and division. Cell contraction and blebbing also frequently occur as part of the cytopathic effect seen during many different viral infections. We now demonstrate that the vaccinia virus protein F11, which localizes to the plasma membrane, is required for ROCK-mediated cell contraction from 2 hr post infection. Curiously, F11-induced cell contraction is dependent on RhoC and not RhoA signaling to ROCK. Moreover, RhoC-driven cell contraction depends on the upstream inhibition of RhoD signaling by F11. This inhibition prevents RhoD from regulating its downstream effector Pak6, alleviating the suppression of RhoC by the kinase. Our observations with vaccinia have now demonstrated that RhoD recruits Pak6 to the plasma membrane to antagonize RhoC signaling during cell contraction and blebbing.Centro de Investigação em Saúde Pública (CISP/PHRC)Escola Nacional de Saúde Pública (ENSP)RUNDurkin, Charlotte HLeite, FlaviaCordeiro, João VHanda, YutakaArakawa, YoshikiValderrama, FerranWay, Michael2018-02-28T23:12:21Z2017-05-082017-05-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/31435eng1534-5807PURE: 2760310https://doi.org/10.1016/j.devcel.2017.04.010info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:31:00Zoai:run.unl.pt:10362/31435Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:02:08.843192Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6
title RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6
spellingShingle RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6
Durkin, Charlotte H
Journal Article
SDG 3 - Good Health and Well-being
title_short RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6
title_full RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6
title_fullStr RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6
title_full_unstemmed RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6
title_sort RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6
author Durkin, Charlotte H
author_facet Durkin, Charlotte H
Leite, Flavia
Cordeiro, João V
Handa, Yutaka
Arakawa, Yoshiki
Valderrama, Ferran
Way, Michael
author_role author
author2 Leite, Flavia
Cordeiro, João V
Handa, Yutaka
Arakawa, Yoshiki
Valderrama, Ferran
Way, Michael
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro de Investigação em Saúde Pública (CISP/PHRC)
Escola Nacional de Saúde Pública (ENSP)
RUN
dc.contributor.author.fl_str_mv Durkin, Charlotte H
Leite, Flavia
Cordeiro, João V
Handa, Yutaka
Arakawa, Yoshiki
Valderrama, Ferran
Way, Michael
dc.subject.por.fl_str_mv Journal Article
SDG 3 - Good Health and Well-being
topic Journal Article
SDG 3 - Good Health and Well-being
description Copyright © 2017 The Francis Crick Institute. Published by Elsevier Inc. All rights reserved.
publishDate 2017
dc.date.none.fl_str_mv 2017-05-08
2017-05-08T00:00:00Z
2018-02-28T23:12:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/31435
url http://hdl.handle.net/10362/31435
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1534-5807
PURE: 2760310
https://doi.org/10.1016/j.devcel.2017.04.010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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