Effectiveness and treatment retention of TNF inhibitors when used as monotherapy versus comedication with csDMARDs in 15 332 patients with psoriatic arthritis. Data from the EuroSpA collaboration

Bibliographic Details
Main Author: Lindström, Ulf
Publication Date: 2021
Other Authors: Di Giuseppe, Daniela, Delcoigne, Bénédicte, Glintborg, Bente, Möller, Burkhard, Ciurea, Adrian, Pombo-Suarez, Manuel, Sanchez-Piedra, Carlos, Eklund, Kari, Relas, Heikki, Gudbjornsson, Bjorn, Love, Thorvardur Jon, Jones, Gareth T., Codreanu, Catalin, Ionescu, Ruxandra, Nekvindova, Lucie, Závada, Jakub, Atas, Nuh, Yolbas, Servet, Fagerli, Karen Minde, Michelsen, Brigitte, Rotar, Žiga, Tomšič, Matija, Iannone, Florenzo, Santos, Maria, Avila-Ribeiro, Pedro, Ørnbjerg, Lykke Midtbøll, Østergaard, Mikkel, Jacobsson, Lennart T. H., Askling, Johan, Nissen, Michael J.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/48625
Summary: © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
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spelling Effectiveness and treatment retention of TNF inhibitors when used as monotherapy versus comedication with csDMARDs in 15 332 patients with psoriatic arthritis. Data from the EuroSpA collaborationArthritisMethotrexatePsoriaticTumour necrosis factor inhibitors© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.Background: Comedication with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) during treatment with tumour necrosis factor inhibitors (TNFi) is extensively used in psoriatic arthritis (PsA), although the additive benefit remains unclear. We aimed to compare treatment outcomes in patients with PsA treated with TNFi and csDMARD comedication versus TNFi monotherapy. Methods: Patients with PsA from 13 European countries who initiated a first TNFi in 2006-2017 were included. Country-specific comparisons of 1 year TNFi retention were performed by csDMARD comedication status, together with HRs for TNFi discontinuation (comedication vs monotherapy), adjusted for age, sex, calendar year, disease duration and Disease Activity Score with 28 joints (DAS28). Adjusted ORs of clinical remission (based on DAS28) at 12 months were calculated. Between-country heterogeneity was assessed using random-effect meta-analyses, combined results were presented when heterogeneity was not significant. Secondary analyses stratified according to TNFi subtype (adalimumab/infliximab/etanercept) and restricted to methotrexate as comedication were performed. Results: In total, 15 332 patients were included (62% comedication, 38% monotherapy). TNFi retention varied across countries, with significant heterogeneity precluding a combined estimate. Comedication was associated with better remission rates, pooled OR 1.25 (1.12-1.41). Methotrexate comedication was associated with improved remission for adalimumab (OR 1.45 (1.23-1.72)) and infliximab (OR 1.55 (1.21-1.98)) and improved retention for infliximab. No effect of comedication was demonstrated for etanercept. Conclusion: This large observational study suggests that, as used in clinical practice, csDMARD and TNFi comedication are associated with improved remission rates, and specifically, comedication with methotrexate increases remission rates for both adalimumab and infliximab.BMJ Publishing Group, Ltd.Repositório da Universidade de LisboaLindström, UlfDi Giuseppe, DanielaDelcoigne, BénédicteGlintborg, BenteMöller, BurkhardCiurea, AdrianPombo-Suarez, ManuelSanchez-Piedra, CarlosEklund, KariRelas, HeikkiGudbjornsson, BjornLove, Thorvardur JonJones, Gareth T.Codreanu, CatalinIonescu, RuxandraNekvindova, LucieZávada, JakubAtas, NuhYolbas, ServetFagerli, Karen MindeMichelsen, BrigitteRotar, ŽigaTomšič, MatijaIannone, FlorenzoSantos, MariaAvila-Ribeiro, PedroØrnbjerg, Lykke MidtbøllØstergaard, MikkelJacobsson, Lennart T. H.Askling, JohanNissen, Michael J.2021-06-17T14:56:24Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/48625engAnn Rheum Dis. 2021 Jun 3:annrheumdis-2021-2200970003-496710.1136/annrheumdis-2021-2200971468-2060info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:35:04Zoai:repositorio.ulisboa.pt:10451/48625Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:16:00.760700Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Effectiveness and treatment retention of TNF inhibitors when used as monotherapy versus comedication with csDMARDs in 15 332 patients with psoriatic arthritis. Data from the EuroSpA collaboration
title Effectiveness and treatment retention of TNF inhibitors when used as monotherapy versus comedication with csDMARDs in 15 332 patients with psoriatic arthritis. Data from the EuroSpA collaboration
spellingShingle Effectiveness and treatment retention of TNF inhibitors when used as monotherapy versus comedication with csDMARDs in 15 332 patients with psoriatic arthritis. Data from the EuroSpA collaboration
Lindström, Ulf
Arthritis
Methotrexate
Psoriatic
Tumour necrosis factor inhibitors
title_short Effectiveness and treatment retention of TNF inhibitors when used as monotherapy versus comedication with csDMARDs in 15 332 patients with psoriatic arthritis. Data from the EuroSpA collaboration
title_full Effectiveness and treatment retention of TNF inhibitors when used as monotherapy versus comedication with csDMARDs in 15 332 patients with psoriatic arthritis. Data from the EuroSpA collaboration
title_fullStr Effectiveness and treatment retention of TNF inhibitors when used as monotherapy versus comedication with csDMARDs in 15 332 patients with psoriatic arthritis. Data from the EuroSpA collaboration
title_full_unstemmed Effectiveness and treatment retention of TNF inhibitors when used as monotherapy versus comedication with csDMARDs in 15 332 patients with psoriatic arthritis. Data from the EuroSpA collaboration
title_sort Effectiveness and treatment retention of TNF inhibitors when used as monotherapy versus comedication with csDMARDs in 15 332 patients with psoriatic arthritis. Data from the EuroSpA collaboration
author Lindström, Ulf
author_facet Lindström, Ulf
Di Giuseppe, Daniela
Delcoigne, Bénédicte
Glintborg, Bente
Möller, Burkhard
Ciurea, Adrian
Pombo-Suarez, Manuel
Sanchez-Piedra, Carlos
Eklund, Kari
Relas, Heikki
Gudbjornsson, Bjorn
Love, Thorvardur Jon
Jones, Gareth T.
Codreanu, Catalin
Ionescu, Ruxandra
Nekvindova, Lucie
Závada, Jakub
Atas, Nuh
Yolbas, Servet
Fagerli, Karen Minde
Michelsen, Brigitte
Rotar, Žiga
Tomšič, Matija
Iannone, Florenzo
Santos, Maria
Avila-Ribeiro, Pedro
Ørnbjerg, Lykke Midtbøll
Østergaard, Mikkel
Jacobsson, Lennart T. H.
Askling, Johan
Nissen, Michael J.
author_role author
author2 Di Giuseppe, Daniela
Delcoigne, Bénédicte
Glintborg, Bente
Möller, Burkhard
Ciurea, Adrian
Pombo-Suarez, Manuel
Sanchez-Piedra, Carlos
Eklund, Kari
Relas, Heikki
Gudbjornsson, Bjorn
Love, Thorvardur Jon
Jones, Gareth T.
Codreanu, Catalin
Ionescu, Ruxandra
Nekvindova, Lucie
Závada, Jakub
Atas, Nuh
Yolbas, Servet
Fagerli, Karen Minde
Michelsen, Brigitte
Rotar, Žiga
Tomšič, Matija
Iannone, Florenzo
Santos, Maria
Avila-Ribeiro, Pedro
Ørnbjerg, Lykke Midtbøll
Østergaard, Mikkel
Jacobsson, Lennart T. H.
Askling, Johan
Nissen, Michael J.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Lindström, Ulf
Di Giuseppe, Daniela
Delcoigne, Bénédicte
Glintborg, Bente
Möller, Burkhard
Ciurea, Adrian
Pombo-Suarez, Manuel
Sanchez-Piedra, Carlos
Eklund, Kari
Relas, Heikki
Gudbjornsson, Bjorn
Love, Thorvardur Jon
Jones, Gareth T.
Codreanu, Catalin
Ionescu, Ruxandra
Nekvindova, Lucie
Závada, Jakub
Atas, Nuh
Yolbas, Servet
Fagerli, Karen Minde
Michelsen, Brigitte
Rotar, Žiga
Tomšič, Matija
Iannone, Florenzo
Santos, Maria
Avila-Ribeiro, Pedro
Ørnbjerg, Lykke Midtbøll
Østergaard, Mikkel
Jacobsson, Lennart T. H.
Askling, Johan
Nissen, Michael J.
dc.subject.por.fl_str_mv Arthritis
Methotrexate
Psoriatic
Tumour necrosis factor inhibitors
topic Arthritis
Methotrexate
Psoriatic
Tumour necrosis factor inhibitors
description © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-17T14:56:24Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/48625
url http://hdl.handle.net/10451/48625
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ann Rheum Dis. 2021 Jun 3:annrheumdis-2021-220097
0003-4967
10.1136/annrheumdis-2021-220097
1468-2060
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