CYP2D6 and IL-6 C-174G variants in schistosomiasis haematobia

Bibliographic Details
Main Author: Cardoso, R.
Publication Date: 2016
Other Authors: Alves, H., Bordalo, A., Richter, J., Botelho, M.C.
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.18/4182
Summary: Aim: Study polymorphic variants in CYP2D6 and the C-174G promoter polymorphism of the IL-6 gene on S. haematobium infected patients from and endemic area of Guinea Bissau. Background: - Schistosome egg associated catechol estrogens induce tumor-like phenotypes in urothelial cells and might cause schistosomiasis associated infertility (Botelho et al, Trends in Parasitol, 2015); - The cytochrome P450 (CYP) genes are involved in estrogen biosynthesis and metabolism and generation of DNA damaging procarcinogens (Blackburn et al, Cancer Causes and Control, 2015); - Very high or very low levels of IL-6 are associated with estrogen metabolism imbalance.
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spelling CYP2D6 and IL-6 C-174G variants in schistosomiasis haematobiaSchistosomiasis HaematobiaS. haematobiumInfertilityGuinea BissauAim: Study polymorphic variants in CYP2D6 and the C-174G promoter polymorphism of the IL-6 gene on S. haematobium infected patients from and endemic area of Guinea Bissau. Background: - Schistosome egg associated catechol estrogens induce tumor-like phenotypes in urothelial cells and might cause schistosomiasis associated infertility (Botelho et al, Trends in Parasitol, 2015); - The cytochrome P450 (CYP) genes are involved in estrogen biosynthesis and metabolism and generation of DNA damaging procarcinogens (Blackburn et al, Cancer Causes and Control, 2015); - Very high or very low levels of IL-6 are associated with estrogen metabolism imbalance.Repositório Científico do Instituto Nacional de SaúdeCardoso, R.Alves, H.Bordalo, A.Richter, J.Botelho, M.C.2017-02-15T14:05:58Z2016-112016-11-01T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10400.18/4182enginfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-26T14:11:01Zoai:repositorio.insa.pt:10400.18/4182Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T21:25:24.892010Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv CYP2D6 and IL-6 C-174G variants in schistosomiasis haematobia
title CYP2D6 and IL-6 C-174G variants in schistosomiasis haematobia
spellingShingle CYP2D6 and IL-6 C-174G variants in schistosomiasis haematobia
Cardoso, R.
Schistosomiasis Haematobia
S. haematobium
Infertility
Guinea Bissau
title_short CYP2D6 and IL-6 C-174G variants in schistosomiasis haematobia
title_full CYP2D6 and IL-6 C-174G variants in schistosomiasis haematobia
title_fullStr CYP2D6 and IL-6 C-174G variants in schistosomiasis haematobia
title_full_unstemmed CYP2D6 and IL-6 C-174G variants in schistosomiasis haematobia
title_sort CYP2D6 and IL-6 C-174G variants in schistosomiasis haematobia
author Cardoso, R.
author_facet Cardoso, R.
Alves, H.
Bordalo, A.
Richter, J.
Botelho, M.C.
author_role author
author2 Alves, H.
Bordalo, A.
Richter, J.
Botelho, M.C.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Cardoso, R.
Alves, H.
Bordalo, A.
Richter, J.
Botelho, M.C.
dc.subject.por.fl_str_mv Schistosomiasis Haematobia
S. haematobium
Infertility
Guinea Bissau
topic Schistosomiasis Haematobia
S. haematobium
Infertility
Guinea Bissau
description Aim: Study polymorphic variants in CYP2D6 and the C-174G promoter polymorphism of the IL-6 gene on S. haematobium infected patients from and endemic area of Guinea Bissau. Background: - Schistosome egg associated catechol estrogens induce tumor-like phenotypes in urothelial cells and might cause schistosomiasis associated infertility (Botelho et al, Trends in Parasitol, 2015); - The cytochrome P450 (CYP) genes are involved in estrogen biosynthesis and metabolism and generation of DNA damaging procarcinogens (Blackburn et al, Cancer Causes and Control, 2015); - Very high or very low levels of IL-6 are associated with estrogen metabolism imbalance.
publishDate 2016
dc.date.none.fl_str_mv 2016-11
2016-11-01T00:00:00Z
2017-02-15T14:05:58Z
dc.type.driver.fl_str_mv conference object
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/4182
url http://hdl.handle.net/10400.18/4182
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833599272116813824

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