Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice

• Main Author: Jr., A. S. Aguiar
• Publication Date: 2013
• Other Authors: Moreira, E. L. G., Hoeller, A. A., Oliveira, P. A., Córdova, F. M., Glaser, V., Walz, R., Cunha, R. A., Leal, R. B., Latini, A., Prediger, R. D. S.
• Format: Article
• Language: por
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: https://hdl.handle.net/10316/27237; https://doi.org/10.1016/j.neuroscience.2013.03.039
• topic: DARPP-32; dyskinesia; exercise; l-DOPA; Parkinson’s disease; 6-OHDA

l-DOPA alleviates the motor symptoms of Parkinson’s disease, but its long-term use is associated with undesirable dyskinesia. We now tested whether exercise can attenuate this l-DOPA-induced dyskinesia (LID). We tested the effects of exercise on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. Animals were treated with l-DOPA/benserazide (25/12.5 mg/kg, i.p.) without and with possibility to exercise (running wheel) during 2 weeks. Exercise drastically prevented the development of LID, and its associated aberrant striatal signaling, namely the hyperphosphorylation of dopamine and cAMP-regulated phosphoprotein 32 kDa protein and c-Fos expression. Our results indicate that exercise can partially prevent the development of LID through the normalization of striatopallidal dopaminergic signaling.