High-altitude hypoxia. A challenging strain targeting cellular redox homeostasis

Bibliographic Details
Main Author: Magalhães,José
Publication Date: 2008
Other Authors: Ascensão,António
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://scielo.pt/scielo.php?script=sci_arttext&pid=S1645-05232008000300014
Summary: After putting forward some evidence of hypobaric hypoxia as a particular stimulus causing systemic, tissue and cellular challenging strains, the present short review is focused on the current findings relating the reasoning of increased tissue generation of reactive oxygen and nitrogen species (RONS) when humans and animals organisms are exposed to high-altitude environments. In contrast to earlier concepts, hypobaric hypoxia-induced decreased physiological oxygen availability seems to be a prompt condition to cellular loss of redox homeostasis resulting in increased oxidative stress, which does not further augment upon reoxygenation. The apparently paradoxical condition of hypoxia-induced free radical production is regulated by very particular and specific cellular mechanisms, being mitochondria special sources and targets of RONS as well as critical organelles related to cellular death mediated by apoptosis.
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spelling High-altitude hypoxia. A challenging strain targeting cellular redox homeostasishypoxiafree radicalsoxidative damagemitochondriaapoptosisAfter putting forward some evidence of hypobaric hypoxia as a particular stimulus causing systemic, tissue and cellular challenging strains, the present short review is focused on the current findings relating the reasoning of increased tissue generation of reactive oxygen and nitrogen species (RONS) when humans and animals organisms are exposed to high-altitude environments. In contrast to earlier concepts, hypobaric hypoxia-induced decreased physiological oxygen availability seems to be a prompt condition to cellular loss of redox homeostasis resulting in increased oxidative stress, which does not further augment upon reoxygenation. The apparently paradoxical condition of hypoxia-induced free radical production is regulated by very particular and specific cellular mechanisms, being mitochondria special sources and targets of RONS as well as critical organelles related to cellular death mediated by apoptosis.Faculdade de Desporto da Universidade do Porto2008-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S1645-05232008000300014Revista Portuguesa de Ciências do Desporto v.8 n.3 2008reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S1645-05232008000300014Magalhães,JoséAscensão,Antónioinfo:eu-repo/semantics/openAccess2024-02-06T17:16:46Zoai:scielo:S1645-05232008000300014Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T13:04:27.631437Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv High-altitude hypoxia. A challenging strain targeting cellular redox homeostasis
title High-altitude hypoxia. A challenging strain targeting cellular redox homeostasis
spellingShingle High-altitude hypoxia. A challenging strain targeting cellular redox homeostasis
Magalhães,José
hypoxia
free radicals
oxidative damage
mitochondria
apoptosis
title_short High-altitude hypoxia. A challenging strain targeting cellular redox homeostasis
title_full High-altitude hypoxia. A challenging strain targeting cellular redox homeostasis
title_fullStr High-altitude hypoxia. A challenging strain targeting cellular redox homeostasis
title_full_unstemmed High-altitude hypoxia. A challenging strain targeting cellular redox homeostasis
title_sort High-altitude hypoxia. A challenging strain targeting cellular redox homeostasis
author Magalhães,José
author_facet Magalhães,José
Ascensão,António
author_role author
author2 Ascensão,António
author2_role author
dc.contributor.author.fl_str_mv Magalhães,José
Ascensão,António
dc.subject.por.fl_str_mv hypoxia
free radicals
oxidative damage
mitochondria
apoptosis
topic hypoxia
free radicals
oxidative damage
mitochondria
apoptosis
description After putting forward some evidence of hypobaric hypoxia as a particular stimulus causing systemic, tissue and cellular challenging strains, the present short review is focused on the current findings relating the reasoning of increased tissue generation of reactive oxygen and nitrogen species (RONS) when humans and animals organisms are exposed to high-altitude environments. In contrast to earlier concepts, hypobaric hypoxia-induced decreased physiological oxygen availability seems to be a prompt condition to cellular loss of redox homeostasis resulting in increased oxidative stress, which does not further augment upon reoxygenation. The apparently paradoxical condition of hypoxia-induced free radical production is regulated by very particular and specific cellular mechanisms, being mitochondria special sources and targets of RONS as well as critical organelles related to cellular death mediated by apoptosis.
publishDate 2008
dc.date.none.fl_str_mv 2008-12-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S1645-05232008000300014
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S1645-05232008000300014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S1645-05232008000300014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Faculdade de Desporto da Universidade do Porto
publisher.none.fl_str_mv Faculdade de Desporto da Universidade do Porto
dc.source.none.fl_str_mv Revista Portuguesa de Ciências do Desporto v.8 n.3 2008
reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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