Creation of antimicrobial biopolymers by the use of recombinant DNA technology

Bibliographic Details
Main Author: Costa, André Manuel Abreu
Publication Date: 2016
Other Authors: Machado, Raul, Rodríguez-Cabello, J.C., Gomes, Andreia C, Casal, Margarida
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/1822/46186
Summary: [Excerpt] The spread of antimicrobials resistant microorganisms has triggered the search for new ways to treat infections. One of these ways is the creation of antimicrobial devices and surfaces that kill or prevent the spread of microorganisms. In the present work we explored the properties of different antimicrobial peptides (AMPs) for the creation of biopolymers with broad antimicrobial activity. Antimicrobial recombinant protein-based polymers (rPBPs) were designed by cloning the DNA sequence coding for the different AMPs in frame with the N-terminus of the elastin-like recombinamer consisting of 200 repetitions of the pentamer VPAVG, here named A200. [...]
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spelling Creation of antimicrobial biopolymers by the use of recombinant DNA technologyCiências Naturais::Outras Ciências Naturais[Excerpt] The spread of antimicrobials resistant microorganisms has triggered the search for new ways to treat infections. One of these ways is the creation of antimicrobial devices and surfaces that kill or prevent the spread of microorganisms. In the present work we explored the properties of different antimicrobial peptides (AMPs) for the creation of biopolymers with broad antimicrobial activity. Antimicrobial recombinant protein-based polymers (rPBPs) were designed by cloning the DNA sequence coding for the different AMPs in frame with the N-terminus of the elastin-like recombinamer consisting of 200 repetitions of the pentamer VPAVG, here named A200. [...]This work was supported by the strategic programme UID/BIA/04050/2013 (POCI-01-0145-FEDER-007569) funded by national funds through the FCT I.P. and by the ERDF through the COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI). By the Spanish Minister of Economy and Competitiveness (MAT2012-38043-C02-01) and Junta de Castilla y León-JCyL (VA152A12-2 and VA155A12-2), Spain. AC and RM, acknowledge FCT for SFRH/BD/75882/2011 and SFRH/BPD/86470/2012 grants, respectively.Universidade do MinhoCosta, André Manuel AbreuMachado, RaulRodríguez-Cabello, J.C.Gomes, Andreia CCasal, Margarida20162016-01-01T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/1822/46186enginfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T05:57:59Zoai:repositorium.sdum.uminho.pt:1822/46186Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T15:36:30.925161Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Creation of antimicrobial biopolymers by the use of recombinant DNA technology
title Creation of antimicrobial biopolymers by the use of recombinant DNA technology
spellingShingle Creation of antimicrobial biopolymers by the use of recombinant DNA technology
Costa, André Manuel Abreu
Ciências Naturais::Outras Ciências Naturais
title_short Creation of antimicrobial biopolymers by the use of recombinant DNA technology
title_full Creation of antimicrobial biopolymers by the use of recombinant DNA technology
title_fullStr Creation of antimicrobial biopolymers by the use of recombinant DNA technology
title_full_unstemmed Creation of antimicrobial biopolymers by the use of recombinant DNA technology
title_sort Creation of antimicrobial biopolymers by the use of recombinant DNA technology
author Costa, André Manuel Abreu
author_facet Costa, André Manuel Abreu
Machado, Raul
Rodríguez-Cabello, J.C.
Gomes, Andreia C
Casal, Margarida
author_role author
author2 Machado, Raul
Rodríguez-Cabello, J.C.
Gomes, Andreia C
Casal, Margarida
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Costa, André Manuel Abreu
Machado, Raul
Rodríguez-Cabello, J.C.
Gomes, Andreia C
Casal, Margarida
dc.subject.por.fl_str_mv Ciências Naturais::Outras Ciências Naturais
topic Ciências Naturais::Outras Ciências Naturais
description [Excerpt] The spread of antimicrobials resistant microorganisms has triggered the search for new ways to treat infections. One of these ways is the creation of antimicrobial devices and surfaces that kill or prevent the spread of microorganisms. In the present work we explored the properties of different antimicrobial peptides (AMPs) for the creation of biopolymers with broad antimicrobial activity. Antimicrobial recombinant protein-based polymers (rPBPs) were designed by cloning the DNA sequence coding for the different AMPs in frame with the N-terminus of the elastin-like recombinamer consisting of 200 repetitions of the pentamer VPAVG, here named A200. [...]
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
dc.type.driver.fl_str_mv conference object
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/46186
url https://hdl.handle.net/1822/46186
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833595420621668352

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