Development of antibody-directed therapies: quo vadis?

Bibliographic Details
Main Author: Rodrigues, Tiago
Publication Date: 2018
Other Authors: Bernardes, Gonçalo J. L.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/50253
Summary: © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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spelling Development of antibody-directed therapies: quo vadis?Anti-tumor agentsAntibody-drug conjugatesBioconjugationDrug deliveryLinkers© 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Less is more: The efficacy of antibody-drug conjugates (ADCs) for cancer therapy is traditionally associated with cleavable linkers for payload release. Evidence now suggests that simpler constructs without cleavable moieties can afford more stable and effective ADCs.We thank FCT Portugal (iFCT) the EU (Marie Sklodowska-Curie ITN ProteinConjugates) and the EPSRC to G.J.L.B. T.R. is a Marie Sklodowska-Curie Fellow (Grant 743640). G.J.L.B. is a Royal Society URF and recipient of an ERC StG (TagIt).John Wiley & Sons, Inc.Repositório da Universidade de LisboaRodrigues, TiagoBernardes, Gonçalo J. L.2021-12-02T15:42:53Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50253engAngew Chem Int Ed Engl. 2018 Feb 19;57(8):2032-20341433-785110.1002/anie.2017121851521-3773info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:38:30Zoai:repositorio.ulisboa.pt:10451/50253Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:18:59.027984Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Development of antibody-directed therapies: quo vadis?
title Development of antibody-directed therapies: quo vadis?
spellingShingle Development of antibody-directed therapies: quo vadis?
Rodrigues, Tiago
Anti-tumor agents
Antibody-drug conjugates
Bioconjugation
Drug delivery
Linkers
title_short Development of antibody-directed therapies: quo vadis?
title_full Development of antibody-directed therapies: quo vadis?
title_fullStr Development of antibody-directed therapies: quo vadis?
title_full_unstemmed Development of antibody-directed therapies: quo vadis?
title_sort Development of antibody-directed therapies: quo vadis?
author Rodrigues, Tiago
author_facet Rodrigues, Tiago
Bernardes, Gonçalo J. L.
author_role author
author2 Bernardes, Gonçalo J. L.
author2_role author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Rodrigues, Tiago
Bernardes, Gonçalo J. L.
dc.subject.por.fl_str_mv Anti-tumor agents
Antibody-drug conjugates
Bioconjugation
Drug delivery
Linkers
topic Anti-tumor agents
Antibody-drug conjugates
Bioconjugation
Drug delivery
Linkers
description © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2021-12-02T15:42:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50253
url http://hdl.handle.net/10451/50253
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Angew Chem Int Ed Engl. 2018 Feb 19;57(8):2032-2034
1433-7851
10.1002/anie.201712185
1521-3773
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons, Inc.
publisher.none.fl_str_mv John Wiley & Sons, Inc.
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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