Pickering Emulsions Stabilized by Calcium Carbonate Particles: A New Topical Formulation

Bibliographic Details
Main Author: Marto, Joana
Publication Date: 2020
Other Authors: Nunes, Andreia, Martins, Ana Margarida, Carvalheira, João, Prazeres, Pedro, Gonçalves, Lídia, Marques, Alexandre, Lucas, António, Ribeiro, Helena Margarida
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/61998
Summary: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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spelling Pickering Emulsions Stabilized by Calcium Carbonate Particles: A New Topical Formulationcalcium carbonatePickering emulsionsQuality by Designemulsion stabilizereco-friendly cosmetics© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Pickering emulsions are systems composed of two immiscible fluids stabilized by solid organic or inorganic particles. Pickering emulsions are particularly useful in cosmetics, where the surfactants are unwanted, as well as in the pharmaceutical field, where transdermal and/or dermal drug delivery is difficult to achieve and controlled drug release is desired. Here, we studied calcium carbonate particles as stabilizers of Pickering emulsions for topical use. An optimized formulation was obtained using a Quality by Design approach. First, a screening experiment was performed to identify the formulation and process critical variables that affect the quality properties of the Pickering emulsion. The optimization of the production was then studied by establishing the design space. The final formulation was hereinafter investigated regarding the pH, rheological properties, and in vitro cytotoxicity assays. The results showed the formulation had a pH compatible with human skin and a shear thinning behavior. Moreover, this formulation showed a strong network structure, with a suitable spreadability on the skin, allowing an easy application. The in vitro assays were performed to assess the potential cytotoxicity of the calcium carbonate-stabilized emulsion and the particles themselves, and the results revealed that the formulation did not significantly affect the cell viability. In conclusion, the use of calcium carbonate particles as a stabilizer ingredient contributed to achieve an eco-friendly Pickering emulsion.This research was funded by Fundação para a Ciência e a Tecnologia, Portugal (UID/DTP/04138/2019, PTDC/MEC-DER/30198/2017, and CEECINST/00145/2018) and by Carbomin.MDPIRepositório da Universidade de LisboaMarto, JoanaNunes, AndreiaMartins, Ana MargaridaCarvalheira, JoãoPrazeres, PedroGonçalves, LídiaMarques, AlexandreLucas, AntónioRibeiro, Helena Margarida2024-01-19T19:11:04Z2020-07-312023-02-27T18:44:12Z2020-07-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/61998engMarto J, Nunes A, Martins AM, Carvalheira J, Prazeres P, Gonçalves L, et al. Pickering emulsions stabilized by calcium carbonate particles: a new topical formulation. Cosmetics [Internet]. 31 de julho de 2020;7(3):62. Disponível em: https://www.mdpi.com/2079-9284/7/3/622079-9284cv-prod-211892410.3390/cosmetics7030062info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:54:25Zoai:repositorio.ulisboa.pt:10451/61998Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:28:19.383368Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Pickering Emulsions Stabilized by Calcium Carbonate Particles: A New Topical Formulation
title Pickering Emulsions Stabilized by Calcium Carbonate Particles: A New Topical Formulation
spellingShingle Pickering Emulsions Stabilized by Calcium Carbonate Particles: A New Topical Formulation
Marto, Joana
calcium carbonate
Pickering emulsions
Quality by Design
emulsion stabilizer
eco-friendly cosmetics
title_short Pickering Emulsions Stabilized by Calcium Carbonate Particles: A New Topical Formulation
title_full Pickering Emulsions Stabilized by Calcium Carbonate Particles: A New Topical Formulation
title_fullStr Pickering Emulsions Stabilized by Calcium Carbonate Particles: A New Topical Formulation
title_full_unstemmed Pickering Emulsions Stabilized by Calcium Carbonate Particles: A New Topical Formulation
title_sort Pickering Emulsions Stabilized by Calcium Carbonate Particles: A New Topical Formulation
author Marto, Joana
author_facet Marto, Joana
Nunes, Andreia
Martins, Ana Margarida
Carvalheira, João
Prazeres, Pedro
Gonçalves, Lídia
Marques, Alexandre
Lucas, António
Ribeiro, Helena Margarida
author_role author
author2 Nunes, Andreia
Martins, Ana Margarida
Carvalheira, João
Prazeres, Pedro
Gonçalves, Lídia
Marques, Alexandre
Lucas, António
Ribeiro, Helena Margarida
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Marto, Joana
Nunes, Andreia
Martins, Ana Margarida
Carvalheira, João
Prazeres, Pedro
Gonçalves, Lídia
Marques, Alexandre
Lucas, António
Ribeiro, Helena Margarida
dc.subject.por.fl_str_mv calcium carbonate
Pickering emulsions
Quality by Design
emulsion stabilizer
eco-friendly cosmetics
topic calcium carbonate
Pickering emulsions
Quality by Design
emulsion stabilizer
eco-friendly cosmetics
description © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2020
dc.date.none.fl_str_mv 2020-07-31
2020-07-31T00:00:00Z
2023-02-27T18:44:12Z
2024-01-19T19:11:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/61998
url http://hdl.handle.net/10451/61998
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Marto J, Nunes A, Martins AM, Carvalheira J, Prazeres P, Gonçalves L, et al. Pickering emulsions stabilized by calcium carbonate particles: a new topical formulation. Cosmetics [Internet]. 31 de julho de 2020;7(3):62. Disponível em: https://www.mdpi.com/2079-9284/7/3/62
2079-9284
cv-prod-2118924
10.3390/cosmetics7030062
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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