Obinutuzumab-Induced Inflammatory Bowel Disease-Like Pancolitis: A First Case Report
| Main Author: | |
|---|---|
| Publication Date: | 2024 |
| Other Authors: | , |
| Format: | Report |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452024000400054 |
Summary: | Abstract Introduction: Obinutuzumab is a type II anti-CD20 monoclonal antibody associated with a higher rate of toxicity when compared to rituximab. Gastrointestinal side-effects have been reported but data is still sparse. Case Presentation: A 47-year-old female with medical history of stage IV follicular non-Hodgkin lymphoma under chemotherapy presented with chronic bloody diarrhea and iron deficiency anemia. Endoscopic and histologic features resembled inflammatory bowel dis-ease (IBD), imposing a thorough differential diagnosis. The diagnosis of obinutuzumab-induced pancolitis was made and the drug was suspended with subsequent clinical improvement. Conclusion: This is the first case report of obinutuzumab-induced pancolitis. The challenging differential diagnosis of IBD required a multi-disciplinary approach with subsequent outcome and management implications. |
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Obinutuzumab-Induced Inflammatory Bowel Disease-Like Pancolitis: A First Case ReportObinutuzumabColitisInflammatory bowel diseaseAbstract Introduction: Obinutuzumab is a type II anti-CD20 monoclonal antibody associated with a higher rate of toxicity when compared to rituximab. Gastrointestinal side-effects have been reported but data is still sparse. Case Presentation: A 47-year-old female with medical history of stage IV follicular non-Hodgkin lymphoma under chemotherapy presented with chronic bloody diarrhea and iron deficiency anemia. Endoscopic and histologic features resembled inflammatory bowel dis-ease (IBD), imposing a thorough differential diagnosis. The diagnosis of obinutuzumab-induced pancolitis was made and the drug was suspended with subsequent clinical improvement. Conclusion: This is the first case report of obinutuzumab-induced pancolitis. The challenging differential diagnosis of IBD required a multi-disciplinary approach with subsequent outcome and management implications.Sociedade Portuguesa de Gastrenterologia2024-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452024000400054GE-Portuguese Journal of Gastroenterology v.31 n.4 2024reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452024000400054Mendes,Raquel R.Figueiredo,Pedro C.Andrade,Isabelinfo:eu-repo/semantics/openAccess2024-11-14T23:02:55Zoai:scielo:S2341-45452024000400054Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T19:13:22.015415Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Obinutuzumab-Induced Inflammatory Bowel Disease-Like Pancolitis: A First Case Report |
| title |
Obinutuzumab-Induced Inflammatory Bowel Disease-Like Pancolitis: A First Case Report |
| spellingShingle |
Obinutuzumab-Induced Inflammatory Bowel Disease-Like Pancolitis: A First Case Report Mendes,Raquel R. Obinutuzumab Colitis Inflammatory bowel disease |
| title_short |
Obinutuzumab-Induced Inflammatory Bowel Disease-Like Pancolitis: A First Case Report |
| title_full |
Obinutuzumab-Induced Inflammatory Bowel Disease-Like Pancolitis: A First Case Report |
| title_fullStr |
Obinutuzumab-Induced Inflammatory Bowel Disease-Like Pancolitis: A First Case Report |
| title_full_unstemmed |
Obinutuzumab-Induced Inflammatory Bowel Disease-Like Pancolitis: A First Case Report |
| title_sort |
Obinutuzumab-Induced Inflammatory Bowel Disease-Like Pancolitis: A First Case Report |
| author |
Mendes,Raquel R. |
| author_facet |
Mendes,Raquel R. Figueiredo,Pedro C. Andrade,Isabel |
| author_role |
author |
| author2 |
Figueiredo,Pedro C. Andrade,Isabel |
| author2_role |
author author |
| dc.contributor.author.fl_str_mv |
Mendes,Raquel R. Figueiredo,Pedro C. Andrade,Isabel |
| dc.subject.por.fl_str_mv |
Obinutuzumab Colitis Inflammatory bowel disease |
| topic |
Obinutuzumab Colitis Inflammatory bowel disease |
| description |
Abstract Introduction: Obinutuzumab is a type II anti-CD20 monoclonal antibody associated with a higher rate of toxicity when compared to rituximab. Gastrointestinal side-effects have been reported but data is still sparse. Case Presentation: A 47-year-old female with medical history of stage IV follicular non-Hodgkin lymphoma under chemotherapy presented with chronic bloody diarrhea and iron deficiency anemia. Endoscopic and histologic features resembled inflammatory bowel dis-ease (IBD), imposing a thorough differential diagnosis. The diagnosis of obinutuzumab-induced pancolitis was made and the drug was suspended with subsequent clinical improvement. Conclusion: This is the first case report of obinutuzumab-induced pancolitis. The challenging differential diagnosis of IBD required a multi-disciplinary approach with subsequent outcome and management implications. |
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2024 |
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2024-08-01 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/report |
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report |
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http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452024000400054 |
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eng |
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eng |
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http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452024000400054 |
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Sociedade Portuguesa de Gastrenterologia |
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Sociedade Portuguesa de Gastrenterologia |
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GE-Portuguese Journal of Gastroenterology v.31 n.4 2024 reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia instacron:RCAAP |
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