Lncrna mort (Znf667-as1) in cancer—is there a possible role in gynecological malignancies?
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Outros |
| Idioma: | eng |
| Título da fonte: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Texto Completo: | http://hdl.handle.net/10362/123592 |
Resumo: | Funding Information: The publication of this manuscript was funded by the European Cooperation in Science & Technology program (EU COST)?COST Action CA18117: GYNOCARE-?European Network for Gynaecological Rare Cancer Research: From Concept to Cure.? R.D.F., S.S., S.A.O., J.J.O, M.P.W., J.B., A.Y., M.V.-S., Y.S., A.G., and J.C.-A. are Action management committee members and/or form part of Working Groups 1?3, and J.C.-A. is the chairperson of this Action. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
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Lncrna mort (Znf667-as1) in cancer—is there a possible role in gynecological malignancies?Cervical cancerEndometrial cancerEpigenetic therapyEpigeneticsLncRNA-based therapyLong non-coding RNAMORT (ZNF667-AS1)Ovarian cancerCatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistrySDG 3 - Good Health and Well-beingFunding Information: The publication of this manuscript was funded by the European Cooperation in Science & Technology program (EU COST)?COST Action CA18117: GYNOCARE-?European Network for Gynaecological Rare Cancer Research: From Concept to Cure.? R.D.F., S.S., S.A.O., J.J.O, M.P.W., J.B., A.Y., M.V.-S., Y.S., A.G., and J.C.-A. are Action management committee members and/or form part of Working Groups 1?3, and J.C.-A. is the chairperson of this Action. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Gynecological cancers (GCs) are currently among the major threats to female health. Moreover, there are different histologic subtypes of these cancers, which are defined as ‘rare’ due to an annual incidence of <6 per 100,000 women. The majority of these tend to be associated with a poor prognosis. Long non-coding RNAs (lncRNAs) play a critical role in the normal development of organisms as well as in tumorigenesis. LncRNAs can be classified into tumor suppressor genes or oncogenes, depending on their function within the cellular context and the signaling pathways in which they are involved. These regulatory RNAs are potential therapeutic targets for cancer due to their tissue and tumor specificity. However, there still needs to be a deeper understanding of the mechanisms by which lncRNAs are involved in the regulation of numerous biological functions in humans, both in normal health and disease. The lncRNA Mortal Obligate RNA Transcript (MORT; alias ZNF667-AS1) has been identified as a tumor-related lncRNA. ZNF667-AS1 gene, located in the human chromosome region 19q13.43, has been shown to be silenced by DNA hypermethylation in several cancers. In this review, we report on the biological functions of ZNF667-AS1 from recent studies and describe the regulatory functions of ZNF667-AS1 in human disease, including cancer. Furthermore, we discuss the emerging insights into the potential role of ZNF667-AS1 as a biomarker and novel therapeutic target in cancer, including GCs (ovarian, cervical, and endometrial cancers).NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNDi Fiore, RiccardoSuleiman, SherifDrago-Ferrante, RosaFelix, AnaO’toole, Sharon A.O’leary, John J.Ward, Mark P.Beirne, JamesYordanov, AngelVasileva-Slaveva, MarielaSubbannayya, YashwanthPentimalli, FrancescaGiordano, AntonioCalleja-Agius, Jean2021-09-02T00:15:32Z2021-08-012021-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/123592eng1661-6596PURE: 33432391https://doi.org/10.3390/ijms22157829info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:55:30Zoai:run.unl.pt:10362/123592Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:26:30.663409Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Lncrna mort (Znf667-as1) in cancer—is there a possible role in gynecological malignancies? |
| title |
Lncrna mort (Znf667-as1) in cancer—is there a possible role in gynecological malignancies? |
| spellingShingle |
Lncrna mort (Znf667-as1) in cancer—is there a possible role in gynecological malignancies? Di Fiore, Riccardo Cervical cancer Endometrial cancer Epigenetic therapy Epigenetics LncRNA-based therapy Long non-coding RNA MORT (ZNF667-AS1) Ovarian cancer Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
| title_short |
Lncrna mort (Znf667-as1) in cancer—is there a possible role in gynecological malignancies? |
| title_full |
Lncrna mort (Znf667-as1) in cancer—is there a possible role in gynecological malignancies? |
| title_fullStr |
Lncrna mort (Znf667-as1) in cancer—is there a possible role in gynecological malignancies? |
| title_full_unstemmed |
Lncrna mort (Znf667-as1) in cancer—is there a possible role in gynecological malignancies? |
| title_sort |
Lncrna mort (Znf667-as1) in cancer—is there a possible role in gynecological malignancies? |
| author |
Di Fiore, Riccardo |
| author_facet |
Di Fiore, Riccardo Suleiman, Sherif Drago-Ferrante, Rosa Felix, Ana O’toole, Sharon A. O’leary, John J. Ward, Mark P. Beirne, James Yordanov, Angel Vasileva-Slaveva, Mariela Subbannayya, Yashwanth Pentimalli, Francesca Giordano, Antonio Calleja-Agius, Jean |
| author_role |
author |
| author2 |
Suleiman, Sherif Drago-Ferrante, Rosa Felix, Ana O’toole, Sharon A. O’leary, John J. Ward, Mark P. Beirne, James Yordanov, Angel Vasileva-Slaveva, Mariela Subbannayya, Yashwanth Pentimalli, Francesca Giordano, Antonio Calleja-Agius, Jean |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Di Fiore, Riccardo Suleiman, Sherif Drago-Ferrante, Rosa Felix, Ana O’toole, Sharon A. O’leary, John J. Ward, Mark P. Beirne, James Yordanov, Angel Vasileva-Slaveva, Mariela Subbannayya, Yashwanth Pentimalli, Francesca Giordano, Antonio Calleja-Agius, Jean |
| dc.subject.por.fl_str_mv |
Cervical cancer Endometrial cancer Epigenetic therapy Epigenetics LncRNA-based therapy Long non-coding RNA MORT (ZNF667-AS1) Ovarian cancer Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
| topic |
Cervical cancer Endometrial cancer Epigenetic therapy Epigenetics LncRNA-based therapy Long non-coding RNA MORT (ZNF667-AS1) Ovarian cancer Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
| description |
Funding Information: The publication of this manuscript was funded by the European Cooperation in Science & Technology program (EU COST)?COST Action CA18117: GYNOCARE-?European Network for Gynaecological Rare Cancer Research: From Concept to Cure.? R.D.F., S.S., S.A.O., J.J.O, M.P.W., J.B., A.Y., M.V.-S., Y.S., A.G., and J.C.-A. are Action management committee members and/or form part of Working Groups 1?3, and J.C.-A. is the chairperson of this Action. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
| publishDate |
2021 |
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2021-09-02T00:15:32Z 2021-08-01 2021-08-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/other |
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other |
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publishedVersion |
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http://hdl.handle.net/10362/123592 |
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eng |
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1661-6596 PURE: 33432391 https://doi.org/10.3390/ijms22157829 |
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