Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids

Bibliographic Details
Main Author: Pedrosa, Pedro
Publication Date: 2021
Other Authors: Baptista, Pedro V., Fernandes, Alexandra R., Guerra, Mauro
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/123695
Summary: UID/FIS/04559/2020
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spelling Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroidsChemistry(all)Chemical Engineering(all)SDG 3 - Good Health and Well-beingUID/FIS/04559/2020The use of nanomaterials to improve medical diagnostics and therapeutics has been rapidly increasing. Among these materials are gold nanoparticles, which can be functionalized to target specific cells, acting as nanovectors for drug delivery, enhanced contrast agents as well as other targeted therapies. Au nanoparticles are very useful as they selectively accumulate in tumour sites due to the enhanced permeability-retention effect. There is however little information about the spatial distribution of the nanoparticles within tumours, which might hinder efficient therapies. In this study, X-ray fluorescence was used to investigate the diffusion of gold nanoparticles in cancer cell spheroids mimicking true tumour growth. Functionalization of the nanoparticles has the effect of allowing better diffusion into and out of the spheroid, while those nanoparticles that are only partially covered rapidly formed aggregates. This clustering led to size exclusion during transport within the tumour, changing its distribution profile while greatly increasing the nanoparticle concentration.DCV - Departamento de Ciências da VidaUCIBIO - Applied Molecular Biosciences UnitLIBPhys-UNLDF – Departamento de FísicaRUNPedrosa, PedroBaptista, Pedro V.Fernandes, Alexandra R.Guerra, Mauro2021-09-03T00:13:37Z2021-07-222021-07-22T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttp://hdl.handle.net/10362/123695eng2046-2069PURE: 33348391https://doi.org/10.1039/d1ra05446einfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:55:35Zoai:run.unl.pt:10362/123695Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:26:34.675347Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids
title Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids
spellingShingle Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids
Pedrosa, Pedro
Chemistry(all)
Chemical Engineering(all)
SDG 3 - Good Health and Well-being
title_short Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids
title_full Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids
title_fullStr Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids
title_full_unstemmed Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids
title_sort Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids
author Pedrosa, Pedro
author_facet Pedrosa, Pedro
Baptista, Pedro V.
Fernandes, Alexandra R.
Guerra, Mauro
author_role author
author2 Baptista, Pedro V.
Fernandes, Alexandra R.
Guerra, Mauro
author2_role author
author
author
dc.contributor.none.fl_str_mv DCV - Departamento de Ciências da Vida
UCIBIO - Applied Molecular Biosciences Unit
LIBPhys-UNL
DF – Departamento de Física
RUN
dc.contributor.author.fl_str_mv Pedrosa, Pedro
Baptista, Pedro V.
Fernandes, Alexandra R.
Guerra, Mauro
dc.subject.por.fl_str_mv Chemistry(all)
Chemical Engineering(all)
SDG 3 - Good Health and Well-being
topic Chemistry(all)
Chemical Engineering(all)
SDG 3 - Good Health and Well-being
description UID/FIS/04559/2020
publishDate 2021
dc.date.none.fl_str_mv 2021-09-03T00:13:37Z
2021-07-22
2021-07-22T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/123695
url http://hdl.handle.net/10362/123695
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2046-2069
PURE: 33348391
https://doi.org/10.1039/d1ra05446e
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833596698417430528

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