Olmesartan-Induced Enteropathy: An Unusual Cause of Villous Atrophy

Detalhes bibliográficos
Autor(a) principal: Eusébio,Marta
Data de Publicação: 2016
Outros Autores: Caldeira,Paulo, Antunes,Artur Gião, Ramos,André, Velasco,Francisco, Cadillá,Jesús, Guerreiro,Horácio
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452016000200006
Resumo: We report a case of a 63-year-old-man presenting with chronic diarrhea and weight loss while on olmesartan treatment for hypertension. Investigation showed multiple nutritional deficiencies associated with diffuse intestinal villous atrophy. Serologies for celiac disease were negative and other causes of villous atrophy were excluded. Olmesartan as a precipitant agent was suspected and withdrawn. Clinical improvement occurred in days with no need for other therapeutic measures. Follow-up at three months showed clinical remission and almost complete recovery of intestinal atrophy. Olmesartan is an angiotensin receptor blocker commonly prescribed for the management of hypertension. Spruelike enteropathy associated with this drug is a recently described entity with few cases reported. It presents with chronic diarrhea and intestinal villous atrophy and should be included in its differential diagnosis. This case intends to alert clinicians for the possibility of this event in a patient on treatment with this drug.
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spelling Olmesartan-Induced Enteropathy: An Unusual Cause of Villous AtrophyAtrophyGastrointestinal DiseasesAngiotensin II Receptor Antagonist/adverse effectsWe report a case of a 63-year-old-man presenting with chronic diarrhea and weight loss while on olmesartan treatment for hypertension. Investigation showed multiple nutritional deficiencies associated with diffuse intestinal villous atrophy. Serologies for celiac disease were negative and other causes of villous atrophy were excluded. Olmesartan as a precipitant agent was suspected and withdrawn. Clinical improvement occurred in days with no need for other therapeutic measures. Follow-up at three months showed clinical remission and almost complete recovery of intestinal atrophy. Olmesartan is an angiotensin receptor blocker commonly prescribed for the management of hypertension. Spruelike enteropathy associated with this drug is a recently described entity with few cases reported. It presents with chronic diarrhea and intestinal villous atrophy and should be included in its differential diagnosis. This case intends to alert clinicians for the possibility of this event in a patient on treatment with this drug.Sociedade Portuguesa de Gastrenterologia2016-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452016000200006GE-Portuguese Journal of Gastroenterology v.23 n.2 2016reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452016000200006Eusébio,MartaCaldeira,PauloAntunes,Artur GiãoRamos,AndréVelasco,FranciscoCadillá,JesúsGuerreiro,Horácioinfo:eu-repo/semantics/openAccess2024-02-06T17:33:40Zoai:scielo:S2341-45452016000200006Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T13:20:24.718797Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Olmesartan-Induced Enteropathy: An Unusual Cause of Villous Atrophy
title Olmesartan-Induced Enteropathy: An Unusual Cause of Villous Atrophy
spellingShingle Olmesartan-Induced Enteropathy: An Unusual Cause of Villous Atrophy
Eusébio,Marta
Atrophy
Gastrointestinal Diseases
Angiotensin II Receptor Antagonist/adverse effects
title_short Olmesartan-Induced Enteropathy: An Unusual Cause of Villous Atrophy
title_full Olmesartan-Induced Enteropathy: An Unusual Cause of Villous Atrophy
title_fullStr Olmesartan-Induced Enteropathy: An Unusual Cause of Villous Atrophy
title_full_unstemmed Olmesartan-Induced Enteropathy: An Unusual Cause of Villous Atrophy
title_sort Olmesartan-Induced Enteropathy: An Unusual Cause of Villous Atrophy
author Eusébio,Marta
author_facet Eusébio,Marta
Caldeira,Paulo
Antunes,Artur Gião
Ramos,André
Velasco,Francisco
Cadillá,Jesús
Guerreiro,Horácio
author_role author
author2 Caldeira,Paulo
Antunes,Artur Gião
Ramos,André
Velasco,Francisco
Cadillá,Jesús
Guerreiro,Horácio
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Eusébio,Marta
Caldeira,Paulo
Antunes,Artur Gião
Ramos,André
Velasco,Francisco
Cadillá,Jesús
Guerreiro,Horácio
dc.subject.por.fl_str_mv Atrophy
Gastrointestinal Diseases
Angiotensin II Receptor Antagonist/adverse effects
topic Atrophy
Gastrointestinal Diseases
Angiotensin II Receptor Antagonist/adverse effects
description We report a case of a 63-year-old-man presenting with chronic diarrhea and weight loss while on olmesartan treatment for hypertension. Investigation showed multiple nutritional deficiencies associated with diffuse intestinal villous atrophy. Serologies for celiac disease were negative and other causes of villous atrophy were excluded. Olmesartan as a precipitant agent was suspected and withdrawn. Clinical improvement occurred in days with no need for other therapeutic measures. Follow-up at three months showed clinical remission and almost complete recovery of intestinal atrophy. Olmesartan is an angiotensin receptor blocker commonly prescribed for the management of hypertension. Spruelike enteropathy associated with this drug is a recently described entity with few cases reported. It presents with chronic diarrhea and intestinal villous atrophy and should be included in its differential diagnosis. This case intends to alert clinicians for the possibility of this event in a patient on treatment with this drug.
publishDate 2016
dc.date.none.fl_str_mv 2016-04-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452016000200006
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dc.language.iso.fl_str_mv eng
language eng
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Gastrenterologia
publisher.none.fl_str_mv Sociedade Portuguesa de Gastrenterologia
dc.source.none.fl_str_mv GE-Portuguese Journal of Gastroenterology v.23 n.2 2016
reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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repository.mail.fl_str_mv info@rcaap.pt
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