Primary malignant peritoneal mesothelioma associated with renal cell carcinoma - A concise review based on a clinical case

• Main Author: Murinello,António
• Publication Date: 2010
• Other Authors: Carvalho,Ana, Figueiredo,A. Manuel, Damásio,Helena, Murillo,M. Jesus, Nunes,Garção, Baptista,Marta, Martins,A. Raquel
• Format: Article
• Language: eng
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782010000500006
• topic: Malignant peritoneal mesothelioma; Asbestos; Paraneoplastic hepatopathy; Renal cell cancer; Cytoreductive surgery; Hyperthermic intraoperative intraperitoneal chemotherapy

Malignant peritoneal mesothelioma mesothelioma is associated with a long a exposure to asbestos and usually has a poor prognosis. Short survival is due to late diagnosis, as patients are frequently pauci-symptomatic until advanced stage. Since the tumor is usually confined to the peritoneal cavity, extensive peritonectomy and hypertermic intraoperative intraperitoneal chemotherapy are associated with increased survival in selected patients. The synchronous occurrence of primary malignant peritoneal mesothelioma and renal cell carcinoma has not yet been described. A concise literature review of symptomatology of peritoneal mesothelioma, paraneoplastic syndromes (dysfunctional biochemical hepatopathy, wasting syndrome); role of asbestos fibers in pathogenesis; mechanisms of intraperitoneal dissemination; CT scan evaluation; relevance of immunohistochemistry for histopathologic diagnosis; staging of tumors; multidisciplinary approach for treatment of these malignancies is performed.